SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x06'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 2x06 L-SULFOLACTATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLU A 215
PRO A 206
LYS A 150
GLY A 216
 None
 1.30A 2hs1B-2x06A:
undetectable		 2hs1B-2x06A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2x06 L-SULFOLACTATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A 342
ILE A  12
ILE A 331
ILE A 320
PHE A  49
 None
 1.05A 3b2rA-2x06A:
undetectable		 3b2rA-2x06A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2x06 L-SULFOLACTATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 TYR A 342
ILE A  12
ILE A 331
ILE A 320
PHE A  49
 None
 1.08A 3b2rB-2x06A:
undetectable		 3b2rB-2x06A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2x06 L-SULFOLACTATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 GLU A 125
TYR A 123
GLY A 134
ALA A 162
ILE A 265
 None
 1.16A 3nmuB-2x06A:
undetectable
3nmuJ-2x06A:
undetectable		 3nmuB-2x06A:
20.36
3nmuJ-2x06A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2x06 L-SULFOLACTATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 4 LEU A 229
GLY A 228
GLY A 226
THR A 176
 None
 0.93A 3si7A-2x06A:
undetectable		 3si7A-2x06A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 2x06 L-SULFOLACTATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLN A  51
THR A  42
ARG A 181
LEU A 185
LEU A 324
 None
 1.40A 4qynB-2x06A:
0.4		 4qynB-2x06A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 2x06 L-SULFOLACTATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A   1
ILE A 343
ILE A 339
 None
 0.67A 4y0qA-2x06A:
undetectable		 4y0qA-2x06A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2x06 L-SULFOLACTATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 TYR A  52
LEU A  85
LEU A 328
ILE A 331
LEU A 324
 None
 1.03A 4zowA-2x06A:
undetectable		 4zowA-2x06A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2x06 L-SULFOLACTATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 4 ILE A 218
ILE A 184
ARG A 181
LEU A 219
 None
 1.28A 5dzkh-2x06A:
undetectable
5dzkn-2x06A:
undetectable
5dzkv-2x06A:
undetectable		 5dzkh-2x06A:
22.32
5dzkn-2x06A:
22.32
5dzkv-2x06A:
0.70