SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x0f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 351
ALA A 335
GLY A 318
ILE A 358
 None
 0.68A 1d4yB-2x0fA:
undetectable		 1d4yB-2x0fA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 280
GLY A 248
VAL A 282
ALA A 256
GLY A 318
 None
None
TRH  A 416 ( 4.4A)
None
None
 1.09A 1nbiA-2x0fA:
undetectable		 1nbiA-2x0fA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 280
GLY A 248
VAL A 282
ALA A 256
GLY A 318
 None
None
TRH  A 416 ( 4.4A)
None
None
 1.09A 1nbiB-2x0fA:
undetectable		 1nbiB-2x0fA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		4 / 4 SER A 404
ILE A 406
VAL A 199
THR A 217
 None
 1.03A 1u70A-2x0fA:
undetectable		 1u70A-2x0fA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 137
GLN A 148
ASN A 163
ALA A 144
LEU A 413
 None
 1.05A 1xdkA-2x0fA:
undetectable		 1xdkA-2x0fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		5 / 9 GLY A 301
SER A 299
LEU A 300
LEU A 311
HIS A 286
 None
 1.41A 1y7iA-2x0fA:
5.6		 1y7iA-2x0fA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 308
GLY A  63
PHE A  62
SER A  66
 TRH  A 416 (-3.6A)
TRH  A 416 (-3.7A)
None
TRH  A 416 (-3.6A)
 1.10A 2a3cA-2x0fA:
undetectable		 2a3cA-2x0fA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 308
GLY A  63
PHE A  62
SER A  66
 TRH  A 416 (-3.6A)
TRH  A 416 (-3.7A)
None
TRH  A 416 (-3.6A)
 1.05A 2a3cB-2x0fA:
undetectable		 2a3cB-2x0fA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		5 / 11 ILE A 168
ALA A 138
ASN A  50
LEU A  52
ALA A 140
 None
 1.11A 2aclE-2x0fA:
undetectable		 2aclE-2x0fA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A  51
ARG A  83
GLN A 116
ALA A  81
ASP A 134
 None
 1.05A 2qjuA-2x0fA:
undetectable		 2qjuA-2x0fA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		4 / 8 SER A 202
ASN A 201
ASP A 171
ARG A 254
 None
None
None
GOL  A1415 (-4.0A)
 1.01A 2v57A-2x0fA:
undetectable		 2v57A-2x0fA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		4 / 8 SER A 202
ASN A 201
ASP A 171
ARG A 254
 None
None
None
GOL  A1415 (-4.0A)
 1.01A 2v57C-2x0fA:
undetectable		 2v57C-2x0fA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		5 / 12 PRO A 331
ILE A 342
ILE A 260
ALA A 263
LEU A 364
 None
 1.14A 3a50A-2x0fA:
undetectable		 3a50A-2x0fA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		4 / 6 ILE A 169
THR A  67
PHE A 403
PHE A 405
 None
None
None
GOL  A 414 ( 4.9A)
 1.32A 3elzB-2x0fA:
undetectable		 3elzB-2x0fA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A  44
ALA A 131
VAL A 130
ALA A  81
 None
 0.72A 4g77A-2x0fA:
undetectable		 4g77A-2x0fA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		4 / 8 SER A 251
VAL A 252
VAL A 282
GLY A 301
 None
GOL  A1415 (-3.8A)
TRH  A 416 ( 4.4A)
None
 0.90A 4mk4A-2x0fA:
3.7		 4mk4A-2x0fA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A 134
THR A 139
THR A 143
ALA A 144
ALA A 146
 None
 1.47A 4u15A-2x0fA:
undetectable		 4u15A-2x0fA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		4 / 6 ARG A  83
PRO A 107
ARG A  40
ILE A  85
 None
 1.22A 5ih0A-2x0fA:
undetectable		 5ih0A-2x0fA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 339
GLU A 241
LEU A 311
ILE A 280
 None
 0.97A 5mzjA-2x0fA:
undetectable		 5mzjA-2x0fA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		6 / 12 LEU A 351
ALA A 335
GLY A 318
ILE A 319
SER A 360
ILE A 358
 None
 1.48A 5t2zB-2x0fA:
undetectable		 5t2zB-2x0fA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 2x0f WSAF
(Geobacillus
stearothermophil
us) 		4 / 5 ILE A 226
ALA A 335
LEU A 312
LYS A 240
 None
 1.06A 6dwnA-2x0fA:
undetectable		 6dwnA-2x0fA:
10.88