SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 7 ASN A 334
TYR A 338
ASN A 168
TYR A 332
 NAD  A 361 (-4.0A)
NAD  A 361 ( 3.8A)
None
None
 0.93A 1dssG-2x0nA:
46.3		 1dssG-2x0nA:
55.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		7 / 7 SER A 164
THR A 166
ASN A 168
CYH A 169
TYR A 332
ASN A 334
TYR A 338
 SO4  A 360 (-2.6A)
SO4  A 360 ( 4.7A)
None
None
None
NAD  A 361 (-4.0A)
NAD  A 361 ( 3.8A)
 0.28A 1dssG-2x0nA:
46.3		 1dssG-2x0nA:
55.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 8 ASN A 334
TYR A 338
ASN A 168
TYR A 332
 NAD  A 361 (-4.0A)
NAD  A 361 ( 3.8A)
None
None
 0.93A 1dssR-2x0nA:
46.1		 1dssR-2x0nA:
55.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		8 / 8 SER A 164
THR A 166
ASN A 168
CYH A 169
HIS A 193
TYR A 332
ASN A 334
TYR A 338
 SO4  A 360 (-2.6A)
SO4  A 360 ( 4.7A)
None
None
None
None
NAD  A 361 (-4.0A)
NAD  A 361 ( 3.8A)
 0.35A 1dssR-2x0nA:
46.1		 1dssR-2x0nA:
55.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 5 LEU A 259
LEU A 276
CYH A 169
THR A 166
 None
None
None
SO4  A 360 ( 4.7A)
 1.30A 2oaxD-2x0nA:
undetectable		 2oaxD-2x0nA:
21.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 8 ASN A 334
TYR A 338
ASN A 168
TYR A 332
 NAD  A 361 (-4.0A)
NAD  A 361 ( 3.8A)
None
None
 0.97A 3dmtC-2x0nA:
50.5		 3dmtC-2x0nA:
90.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		8 / 8 SER A 164
THR A 166
ASN A 168
CYH A 169
HIS A 193
TYR A 332
ASN A 334
TYR A 338
 SO4  A 360 (-2.6A)
SO4  A 360 ( 4.7A)
None
None
None
None
NAD  A 361 (-4.0A)
NAD  A 361 ( 3.8A)
 0.38A 3dmtC-2x0nA:
50.5		 3dmtC-2x0nA:
90.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 8 PHE A   9
GLY A  13
ILE A  84
CYH A  86
 None
 0.97A 3ko0O-2x0nA:
undetectable
3ko0Q-2x0nA:
undetectable		 3ko0O-2x0nA:
14.48
3ko0Q-2x0nA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 ARG A 278
LYS A 277
LYS A 281
 None
 1.24A 4k50I-2x0nA:
undetectable		 4k50I-2x0nA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 LYS A  68
PRO A  69
SER A  70
 None
 0.33A 4k50I-2x0nA:
undetectable		 4k50I-2x0nA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 11 SER A 164
LEU A 170
PRO A 172
VAL A 144
THR A 142
 SO4  A 360 (-2.6A)
None
None
None
None
 1.26A 4uuuB-2x0nA:
undetectable		 4uuuB-2x0nA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 THR A 167
ALA A 163
ASN A 168
 None
 0.64A 5ersA-2x0nA:
undetectable		 5ersA-2x0nA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 MET A  15
HIS A  55
GLY A 337
 None
 0.82A 5gwzB-2x0nA:
undetectable		 5gwzB-2x0nA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 5 HIS A  55
HIS A  60
LEU A  77
VAL A  79
 None
 1.04A 6bc9A-2x0nA:
undetectable		 6bc9A-2x0nA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 ARG A 323
ARG A 324
ASP A 266
 None
 0.60A 6d8pA-2x0nA:
undetectable		 6d8pA-2x0nA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 LEU A  26
VAL A  79
ALA A  46
PHE A   9
VAL A  35
 None
 1.49A 6drxA-2x0nA:
undetectable		 6drxA-2x0nA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 LEU A  26
VAL A  79
PHE A  58
PHE A   9
VAL A  35
 None
 1.40A 6drxA-2x0nA:
undetectable		 6drxA-2x0nA:
22.88