SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2x12 FIMBRIAE-ASSOCIATED
PROTEIN FAP1
(Streptococcus
parasanguinis) 		4 / 5 PRO A 388
THR A 355
VAL A 354
GLY A 353
 None
 1.16A 3elzA-2x12A:
1.2		 3elzA-2x12A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 2x12 FIMBRIAE-ASSOCIATED
PROTEIN FAP1
(Streptococcus
parasanguinis) 		4 / 4 TYR A 286
THR A 384
VAL A 346
ILE A 419
 None
 1.36A 4jx1F-2x12A:
undetectable		 4jx1F-2x12A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 2x12 FIMBRIAE-ASSOCIATED
PROTEIN FAP1
(Streptococcus
parasanguinis) 		4 / 5 GLU A 344
ALA A 382
GLU A 392
ASN A 413
 None
 1.25A 5dwkC-2x12A:
undetectable		 5dwkC-2x12A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2x12 FIMBRIAE-ASSOCIATED
PROTEIN FAP1
(Streptococcus
parasanguinis) 		4 / 7 ILE A 377
THR A 310
MET A 379
TRP A 282
 None
 1.34A 5ljcA-2x12A:
undetectable		 5ljcA-2x12A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2x12 FIMBRIAE-ASSOCIATED
PROTEIN FAP1
(Streptococcus
parasanguinis) 		4 / 6 ILE A 377
THR A 310
MET A 379
TRP A 282
 None
 1.32A 5ljeA-2x12A:
undetectable		 5ljeA-2x12A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2x12 FIMBRIAE-ASSOCIATED
PROTEIN FAP1
(Streptococcus
parasanguinis) 		4 / 8 ASP A 414
SER A 415
TYR A 336
GLY A 342
 None
 1.10A 6giqL-2x12A:
undetectable
6giqP-2x12A:
undetectable
6giqT-2x12A:
undetectable		 6giqL-2x12A:
22.43
6giqP-2x12A:
21.74
6giqT-2x12A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 2x12 FIMBRIAE-ASSOCIATED
PROTEIN FAP1
(Streptococcus
parasanguinis) 		5 / 12 ILE A 266
ILE A 242
VAL A 284
THR A 283
ILE A 269
 None
 1.19A 6hlpA-2x12A:
undetectable		 6hlpA-2x12A:
19.77