SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x1g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2x1g CADMUS
(Drosophila
melanogaster) 		6 / 11 LEU F 149
LEU F 145
VAL F 182
ARG F 188
TYR F 189
LYS F 191
 None
 1.28A 1y4lB-2x1gF:
undetectable		 1y4lB-2x1gF:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 2x1g CADMUS
(Drosophila
melanogaster) 		5 / 10 LEU F 919
ALA F 881
LEU F 901
ILE F 943
THR F 880
 None
 1.08A 2w9gA-2x1gF:
undetectable		 2w9gA-2x1gF:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 2x1g CADMUS
(Drosophila
melanogaster) 		5 / 12 LEU F 345
LEU F 287
MET F 268
ILE F 272
HIS F 327
 None
 1.50A 2ydoA-2x1gF:
0.4		 2ydoA-2x1gF:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2x1g CADMUS
(Drosophila
melanogaster) 		5 / 11 LEU F 919
ALA F 881
LEU F 901
ILE F 943
THR F 880
 None
 1.12A 3frbX-2x1gF:
undetectable		 3frbX-2x1gF:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2x1g CADMUS
(Drosophila
melanogaster) 		4 / 8 LEU F 190
TYR F 189
VAL F 233
LEU F 260
 None
 1.00A 4l1xA-2x1gF:
undetectable		 4l1xA-2x1gF:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 2x1g CADMUS
(Drosophila
melanogaster) 		6 / 12 SER F  90
PHE F  43
GLY F  60
ALA F  61
ILE F  87
LEU F  68
 None
 1.15A 6dwnD-2x1gF:
undetectable		 6dwnD-2x1gF:
6.11