SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x1m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A 276
LEU A 175
LEU A 178
ILE A 289
HIS A 260
 None
 1.36A 1a52A-2x1mA:
undetectable		 1a52A-2x1mA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A 276
LEU A 175
LEU A 178
ILE A 289
HIS A 260
 None
 1.38A 1a52B-2x1mA:
undetectable		 1a52B-2x1mA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ALA A 276
LEU A 175
LEU A 178
ILE A 289
HIS A 270
 None
None
None
None
MET  A 600 (-4.6A)
 1.18A 1ereA-2x1mA:
undetectable		 1ereA-2x1mA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A  22
GLY A  21
GLY A 263
ASP A 265
HIS A 292
 None
 1.23A 1ffyA-2x1mA:
22.7		 1ffyA-2x1mA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 PHE A 290
PHE A 334
ALA A 291
ILE A 262
 None
 1.02A 1fxhA-2x1mA:
undetectable
1fxhB-2x1mA:
undetectable		 1fxhA-2x1mA:
18.10
1fxhB-2x1mA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ALA A 106
LYS A 109
ASP A 113
ALA A 114
 None
 0.42A 1iwhA-2x1mA:
undetectable		 1iwhA-2x1mA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 8 THR A 454
PHE A 427
LEU A 360
SER A 428
GLY A 421
 None
 1.42A 1jhqA-2x1mA:
undetectable		 1jhqA-2x1mA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 8 THR A 454
PHE A 427
LEU A 360
SER A 428
GLY A 421
 None
 1.43A 1jhvA-2x1mA:
1.6		 1jhvA-2x1mA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A  30
PHE A 404
VAL A 468
 None
 0.78A 1kijB-2x1mA:
undetectable		 1kijB-2x1mA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLU A 456
ARG A 446
LEU A 390
ASP A 386
 None
 1.00A 1mt1B-2x1mA:
undetectable
1mt1C-2x1mA:
undetectable		 1mt1B-2x1mA:
11.46
1mt1C-2x1mA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ILE A 460
LEU A 396
VAL A 400
ALA A 408
 None
 1.00A 1mz9A-2x1mA:
undetectable		 1mz9A-2x1mA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLU A 181
LEU A 175
LEU A 178
LEU A 176
 None
 1.11A 1np1A-2x1mA:
undetectable		 1np1A-2x1mA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		8 / 11 ALA A  10
GLY A  21
HIS A  22
GLU A  25
GLY A 263
ASP A 265
ILE A 266
HIS A 292
 MET  A 600 ( 3.9A)
None
None
None
None
None
MET  A 600 (-3.9A)
None
 0.62A 1pg2A-2x1mA:
38.1		 1pg2A-2x1mA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A 276
LEU A 175
LEU A 178
ILE A 289
HIS A 270
 None
None
None
None
MET  A 600 (-4.6A)
 1.16A 1qkuA-2x1mA:
undetectable		 1qkuA-2x1mA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A 276
LEU A 175
LEU A 178
ILE A 289
HIS A 270
 None
None
None
None
MET  A 600 (-4.6A)
 1.15A 1qkuB-2x1mA:
undetectable		 1qkuB-2x1mA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A 276
LEU A 175
LEU A 178
ILE A 289
HIS A 270
 None
None
None
None
MET  A 600 (-4.6A)
 1.16A 1qkuC-2x1mA:
undetectable		 1qkuC-2x1mA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  21
HIS A  22
GLY A 263
ASP A 265
HIS A 292
 None
 0.44A 1qu2A-2x1mA:
22.7		 1qu2A-2x1mA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A  45
MET A 409
THR A   8
ILE A   7
PHE A   5
 None
 1.15A 1xomB-2x1mA:
undetectable		 1xomB-2x1mA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ARG A 174
ALA A 276
ALA A 114
SER A 169
LEU A 168
 CXS  A 602 (-4.2A)
None
None
None
None
 1.06A 2bxeB-2x1mA:
undetectable		 2bxeB-2x1mA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 MET A 409
LEU A 329
GLU A  25
MET A 261
 None
 0.98A 2kuhA-2x1mA:
undetectable		 2kuhA-2x1mA:
8.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		10 / 11 ALA A  10
ALA A  12
GLY A  21
HIS A  22
GLU A  25
GLY A 263
ASP A 265
ILE A 266
HIS A 292
TRP A 294
 MET  A 600 ( 3.9A)
MET  A 600 (-3.8A)
None
None
None
None
None
MET  A 600 (-3.9A)
None
None
 0.71A 2x1lA-2x1mA:
57.8		 2x1lA-2x1mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		10 / 12 ALA A  10
ALA A  12
GLY A  21
HIS A  22
GLU A  25
GLY A 263
ASP A 265
ILE A 266
HIS A 292
LEU A 295
 MET  A 600 ( 3.9A)
MET  A 600 (-3.8A)
None
None
None
None
None
MET  A 600 (-3.9A)
None
None
 0.57A 2x1lB-2x1mA:
55.4		 2x1lB-2x1mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		10 / 12 ALA A  10
ALA A  12
GLY A  21
HIS A  22
GLU A  25
GLY A 263
ASP A 265
ILE A 266
HIS A 292
TRP A 294
 MET  A 600 ( 3.9A)
MET  A 600 (-3.8A)
None
None
None
None
None
MET  A 600 (-3.9A)
None
None
 0.73A 2x1lB-2x1mA:
55.4		 2x1lB-2x1mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		10 / 11 ALA A  10
ALA A  12
GLY A  21
HIS A  22
GLU A  25
GLY A 263
ASP A 265
ILE A 266
HIS A 292
TRP A 294
 MET  A 600 ( 3.9A)
MET  A 600 (-3.8A)
None
None
None
None
None
MET  A 600 (-3.9A)
None
None
 0.71A 2x1lC-2x1mA:
54.7		 2x1lC-2x1mA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 LEU A 168
ILE A 107
ARG A 110
TRP A 108
 None
 1.47A 2zlcA-2x1mA:
undetectable		 2zlcA-2x1mA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 156
ALA A 154
GLU A 138
THR A 152
ILE A 195
 None
 1.00A 3gcsA-2x1mA:
undetectable		 3gcsA-2x1mA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 252
PRO A 256
PHE A 251
 None
 0.85A 3thrC-2x1mA:
undetectable		 3thrC-2x1mA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A 506
GLY A 507
GLN A 362
 None
 0.54A 3v4tH-2x1mA:
undetectable		 3v4tH-2x1mA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 HIS A  52
HIS A 100
ASP A 130
ASP A  50
 None
None
None
MET  A 600 (-4.3A)
 1.29A 4blvA-2x1mA:
undetectable		 4blvA-2x1mA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  21
HIS A  22
VAL A 229
GLY A 263
ASP A 265
 None
 0.90A 5hg0B-2x1mA:
6.2		 5hg0B-2x1mA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 THR A  95
ASP A  50
ASP A 232
GLY A  53
 None
MET  A 600 (-4.3A)
None
None
 0.81A 5hwaA-2x1mA:
undetectable		 5hwaA-2x1mA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 288
ALA A 408
THR A  29
GLY A 335
 2HP  A 601 (-3.2A)
None
None
None
 0.90A 5v0vA-2x1mA:
undetectable		 5v0vA-2x1mA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A  12
THR A  49
THR A  95
ALA A  67
 MET  A 600 (-3.8A)
None
None
None
 0.95A 5x2tI-2x1mA:
undetectable
5x2tJ-2x1mA:
undetectable
5x2tK-2x1mA:
undetectable
5x2tL-2x1mA:
undetectable		 5x2tI-2x1mA:
15.19
5x2tJ-2x1mA:
15.69
5x2tK-2x1mA:
15.19
5x2tL-2x1mA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A  12
THR A  49
THR A  95
ALA A  68
 MET  A 600 (-3.8A)
None
None
None
 0.87A 5x2tI-2x1mA:
undetectable
5x2tJ-2x1mA:
undetectable
5x2tK-2x1mA:
undetectable
5x2tL-2x1mA:
undetectable		 5x2tI-2x1mA:
15.19
5x2tJ-2x1mA:
15.69
5x2tK-2x1mA:
15.19
5x2tL-2x1mA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 LEU A 365
ALA A 361
LEU A 476
ILE A 460
LEU A 420
 None
 1.36A 6cbzB-2x1mA:
undetectable		 6cbzB-2x1mA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_A_NCTA405_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 TYR A   6
THR A  47
TYR A 237
THR A  29
 None
None
MET  A 600 (-4.6A)
None
 1.03A 6cnkA-2x1mA:
3.6
6cnkB-2x1mA:
4.7		 6cnkA-2x1mA:
9.39
6cnkB-2x1mA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 239
ALA A 103
LYS A 105
 None
 0.70A 6fgcA-2x1mA:
undetectable		 6fgcA-2x1mA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 2x1m METHIONYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 239
ALA A 103
LYS A 105
 None
 0.70A 6fgdA-2x1mA:
2.6		 6fgdA-2x1mA:
22.51