SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x24'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		6 / 12 ALA A 142
SER A 254
ILE A 253
LEU A 335
ARG A 111
ILE A 113
 None
 1.22A 1dhiA-2x24A:
undetectable		 1dhiA-2x24A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		6 / 12 ILE A 147
SER A 254
ILE A 253
LEU A 335
ARG A 111
ILE A 113
 None
 1.25A 1dhiA-2x24A:
undetectable		 1dhiA-2x24A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		6 / 12 ALA A 142
SER A 254
ILE A 253
LEU A 335
ARG A 111
ILE A 113
 None
 1.24A 1dhjA-2x24A:
undetectable		 1dhjA-2x24A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		6 / 12 ILE A 147
SER A 254
ILE A 253
LEU A 335
ARG A 111
ILE A 113
 None
 1.23A 1dhjA-2x24A:
undetectable		 1dhjA-2x24A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		4 / 6 LEU A 373
ILE A 359
ASP A 546
PRO A 519
 None
 0.95A 1ditH-2x24A:
undetectable
1ditP-2x24A:
undetectable		 1ditH-2x24A:
14.82
1ditP-2x24A:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		6 / 12 ALA A 142
SER A 254
ILE A 253
LEU A 335
ARG A 111
ILE A 113
 None
 1.21A 1draA-2x24A:
undetectable		 1draA-2x24A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		6 / 12 ILE A 147
SER A 254
ILE A 253
LEU A 335
ARG A 111
ILE A 113
 None
 1.23A 1draA-2x24A:
undetectable		 1draA-2x24A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		6 / 12 ALA A 142
SER A 254
ILE A 253
LEU A 335
ARG A 111
ILE A 113
 None
 1.20A 1drbA-2x24A:
undetectable		 1drbA-2x24A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		6 / 12 ILE A 147
SER A 254
ILE A 253
LEU A 335
ARG A 111
ILE A 113
 None
 1.25A 1drbA-2x24A:
undetectable		 1drbA-2x24A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 12 GLY A 235
PRO A 129
GLY A 227
LEU A 136
LEU A 133
 None
 0.99A 1eizA-2x24A:
2.0		 1eizA-2x24A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 12 GLY A 235
PRO A 129
GLY A 227
LEU A 136
LEU A 133
 None
 0.98A 1ej0A-2x24A:
undetectable		 1ej0A-2x24A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		3 / 3 TRP A 403
HIS A 318
MET A 400
 None
 1.08A 1l5qB-2x24A:
2.8		 1l5qB-2x24A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		4 / 5 PRO A  46
VAL A  42
TYR A  70
GLU A  72
 None
 1.38A 1m9jB-2x24A:
0.0		 1m9jB-2x24A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		4 / 4 VAL A 421
ALA A 423
LEU A 373
PHE A 479
 None
 1.08A 1q97B-2x24A:
undetectable		 1q97B-2x24A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 11 VAL A 328
ILE A 331
LEU A 332
LEU A  68
LEU A 102
 None
 1.26A 2a15A-2x24A:
undetectable		 2a15A-2x24A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		6 / 12 ALA A 142
SER A 254
ILE A 253
LEU A 335
ARG A 111
ILE A 113
 None
 1.23A 2drcA-2x24A:
undetectable		 2drcA-2x24A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		6 / 12 ILE A 147
SER A 254
ILE A 253
LEU A 335
ARG A 111
ILE A 113
 None
 1.23A 2drcA-2x24A:
undetectable		 2drcA-2x24A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H9T_H_SVRH301_1
(THROMBIN)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 11 LYS A 185
TRP A 174
VAL A 172
GLN A 171
GLU A 165
 None
 1.32A 2h9tH-2x24A:
undetectable		 2h9tH-2x24A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 10 ASP A 457
ILE A 478
PHE A 485
ILE A 541
GLY A 500
 None
 1.28A 2v0mA-2x24A:
undetectable		 2v0mA-2x24A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 11 PHE A 469
ASP A 468
VAL A 319
TRP A 334
VAL A 408
 None
 1.25A 2vcdA-2x24A:
undetectable		 2vcdA-2x24A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 12 ILE A 263
ALA A 154
GLY A 125
GLY A 157
THR A  39
 None
 1.07A 2y7hB-2x24A:
undetectable		 2y7hB-2x24A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 12 ILE A 263
ALA A 154
GLY A 125
GLY A 157
THR A  39
 None
 1.07A 2y7hC-2x24A:
undetectable		 2y7hC-2x24A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		3 / 3 LEU A 659
VAL A 706
ARG A 656
 None
 0.87A 3b0wB-2x24A:
undetectable		 3b0wB-2x24A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		6 / 12 ALA A 142
SER A 254
ILE A 253
LEU A 335
ARG A 111
ILE A 113
 None
 1.23A 3drcA-2x24A:
undetectable		 3drcA-2x24A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		6 / 12 ILE A 147
SER A 254
ILE A 253
LEU A 335
ARG A 111
ILE A 113
 None
 1.23A 3drcA-2x24A:
undetectable		 3drcA-2x24A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		3 / 3 SER A 388
GLN A 387
PHE A 361
 None
 0.81A 3g4lC-2x24A:
undetectable		 3g4lC-2x24A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		4 / 6 GLN A 708
LEU A 710
GLU A 711
LEU A 660
 None
 0.91A 3h5gA-2x24A:
undetectable
3h5gC-2x24A:
undetectable		 3h5gA-2x24A:
3.59
3h5gC-2x24A:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 12 ILE A 147
SER A 254
ILE A 253
LEU A 335
ARG A 111
 None
 1.18A 3ia4B-2x24A:
undetectable		 3ia4B-2x24A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 12 ILE A 147
SER A 254
ILE A 253
LEU A 335
ARG A 111
 None
 1.18A 3ia4D-2x24A:
undetectable		 3ia4D-2x24A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		4 / 8 TYR A 517
TYR A 544
ARG A 654
LEU A 655
 None
 1.15A 3wipG-2x24A:
undetectable
3wipH-2x24A:
undetectable		 3wipG-2x24A:
16.30
3wipH-2x24A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 12 TYR A 135
GLY A 264
ILE A 282
LEU A 270
VAL A 268
 None
 1.06A 4azwA-2x24A:
undetectable		 4azwA-2x24A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 10 LEU A 270
TYR A 135
ASP A 132
GLY A 235
SER A 236
 None
 1.18A 4bwlC-2x24A:
undetectable		 4bwlC-2x24A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		4 / 5 ALA A 260
ILE A 263
LEU A 267
ASN A 155
 None
 1.02A 4g19A-2x24A:
undetectable		 4g19A-2x24A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 10 ALA A 265
GLY A 306
ILE A 310
VAL A 274
VAL A 268
 None
 1.06A 4j5jB-2x24A:
undetectable		 4j5jB-2x24A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		3 / 3 LEU A 152
MET A 255
ASP A 112
 None
 0.79A 4j7xB-2x24A:
4.0		 4j7xB-2x24A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 12 ILE A 113
VAL A 150
LEU A 115
LEU A 332
LEU A 335
 None
 0.97A 4m11B-2x24A:
undetectable		 4m11B-2x24A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 12 ILE A 113
VAL A 150
LEU A 115
LEU A 332
LEU A 335
 None
 0.96A 4m11C-2x24A:
undetectable		 4m11C-2x24A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		4 / 8 MET A  84
GLU A  72
GLU A  92
TYR A 135
 None
 1.19A 4mj8A-2x24A:
undetectable
4mj8C-2x24A:
undetectable		 4mj8A-2x24A:
12.11
4mj8C-2x24A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		4 / 8 MET A  84
GLU A  72
GLU A  92
TYR A 151
 None
 1.12A 4mj8A-2x24A:
undetectable
4mj8C-2x24A:
undetectable		 4mj8A-2x24A:
12.11
4mj8C-2x24A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 12 MET A 532
VAL A 531
ILE A 422
VAL A 407
ALA A 459
 None
 1.09A 4o1zB-2x24A:
undetectable		 4o1zB-2x24A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 12 ILE A 147
ILE A 253
LEU A 335
ARG A 111
ILE A 113
 None
 1.07A 4pthA-2x24A:
undetectable		 4pthA-2x24A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		4 / 8 PRO A 519
LEU A 373
VAL A 408
VAL A 421
 None
 0.91A 4pwdA-2x24A:
2.1		 4pwdA-2x24A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 11 ALA A 142
SER A 254
ILE A 253
LEU A 335
ARG A 111
 None
 1.28A 4qi9C-2x24A:
undetectable		 4qi9C-2x24A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 11 ILE A 147
SER A 254
ILE A 253
LEU A 335
ARG A 111
 None
 1.15A 4qi9C-2x24A:
undetectable		 4qi9C-2x24A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 11 ILE A 147
SER A 254
ILE A 253
LEU A 335
ARG A 111
 None
 1.16A 4qleB-2x24A:
undetectable		 4qleB-2x24A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 12 SER A 254
LEU A 335
MET A 338
ARG A 149
ILE A 113
 None
 1.08A 4x1fA-2x24A:
undetectable		 4x1fA-2x24A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 12 SER A 254
LEU A 335
MET A 338
ARG A 149
ILE A 113
 None
 1.02A 4x1gA-2x24A:
undetectable		 4x1gA-2x24A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		4 / 7 ALA A 522
ASP A 369
ARG A 371
GLU A 398
 None
 0.95A 5bs8A-2x24A:
undetectable
5bs8B-2x24A:
undetectable
5bs8C-2x24A:
undetectable		 5bs8A-2x24A:
22.99
5bs8B-2x24A:
16.22
5bs8C-2x24A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		4 / 7 ALA A 522
ASP A 369
ARG A 371
GLU A 398
 None
 0.94A 5btdA-2x24A:
undetectable
5btdB-2x24A:
undetectable
5btdC-2x24A:
undetectable		 5btdA-2x24A:
22.99
5btdB-2x24A:
16.22
5btdC-2x24A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		4 / 7 ALA A 522
ASP A 369
ARG A 371
GLU A 398
 None
 0.91A 5btdA-2x24A:
undetectable
5btdC-2x24A:
undetectable
5btdD-2x24A:
undetectable		 5btdA-2x24A:
22.99
5btdC-2x24A:
22.99
5btdD-2x24A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		5 / 11 ASP A 369
ALA A 423
LYS A 461
GLU A 398
VAL A 421
 None
 1.33A 5hw4B-2x24A:
undetectable		 5hw4B-2x24A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		4 / 5 ARG A 111
MET A 100
THR A 101
LEU A  68
 None
 1.43A 5z86J-2x24A:
undetectable		 5z86J-2x24A:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		4 / 6 GLN A 708
TRP A 709
HIS A 713
ALA A 712
 None
 1.38A 6f6jC-2x24A:
undetectable
6f6jD-2x24A:
undetectable		 6f6jC-2x24A:
19.35
6f6jD-2x24A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		3 / 3 THR A 409
ALA A 465
LYS A 467
 None
 0.62A 6fgcA-2x24A:
undetectable		 6fgcA-2x24A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		3 / 3 THR A 409
ALA A 465
LYS A 467
 None
 0.59A 6fgdA-2x24A:
undetectable		 6fgdA-2x24A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 2x24 ACETYL-COA
CARBOXYLASE
(Bos
taurus) 		4 / 6 SER A 486
ALA A 459
THR A 462
ALA A 424
 None
 0.79A 6ma6A-2x24A:
undetectable		 6ma6A-2x24A:
7.28