SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens) 		4 / 6 PHE B  53
ILE B  10
VAL B  20
PHE B  22
 None
 0.84A 2cizA-2x25B:
undetectable		 2cizA-2x25B:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens) 		3 / 3 TYR B  48
GLY B  50
PHE B  67
 None
 0.63A 2m2pB-2x25B:
undetectable		 2m2pB-2x25B:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens) 		4 / 7 SER B  40
PHE B 112
ILE B 114
PHE B  53
 None
 1.14A 2q6hA-2x25B:
undetectable		 2q6hA-2x25B:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens) 		4 / 7 SER B  40
PHE B 112
ILE B 114
PHE B  53
 None
 1.14A 2qb4A-2x25B:
undetectable		 2qb4A-2x25B:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens) 		4 / 6 SER B  40
PHE B 112
ILE B 114
PHE B  53
 None
 1.13A 2qeiA-2x25B:
undetectable		 2qeiA-2x25B:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens) 		4 / 6 PHE B  22
PHE B  36
GLY B  64
GLY B  65
 None
 0.90A 2qr2A-2x25B:
undetectable
2qr2B-2x25B:
undetectable		 2qr2A-2x25B:
22.71
2qr2B-2x25B:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens) 		4 / 5 GLY B  64
GLY B  65
PHE B  22
PHE B  36
 None
 0.84A 2qr2A-2x25B:
undetectable
2qr2B-2x25B:
undetectable		 2qr2A-2x25B:
22.71
2qr2B-2x25B:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens) 		4 / 6 PHE B  22
PHE B  36
GLY B  64
GLY B  65
 None
 0.79A 2qx6A-2x25B:
undetectable
2qx6B-2x25B:
undetectable		 2qx6A-2x25B:
22.71
2qx6B-2x25B:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens) 		5 / 12 THR B  41
SER B  40
GLU B  34
LEU B  24
PRO B   4
 None
 1.46A 4uinH-2x25B:
undetectable
4uinL-2x25B:
undetectable		 4uinH-2x25B:
20.44
4uinL-2x25B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens) 		3 / 3 LEU B  98
PHE B  25
ILE B  97
 None
 0.61A 5dzk1-2x25B:
undetectable
5dzkF-2x25B:
undetectable
5dzkM-2x25B:
undetectable		 5dzk1-2x25B:
0.59
5dzkF-2x25B:
19.81
5dzkM-2x25B:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens) 		5 / 12 GLY B 109
ILE B  78
ASN B 102
PHE B  36
LEU B  98
 None
None
ALY  B 125 ( 3.4A)
None
None
 1.02A 5fa8A-2x25B:
undetectable		 5fa8A-2x25B:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens) 		3 / 3 LYS B 126
HIS B  92
HIS B 126
 ALY  B 125 ( 3.5A)
None
ALY  B 125 ( 3.6A)
 1.44A 5oexB-2x25B:
undetectable		 5oexB-2x25B:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens) 		4 / 6 PHE B  60
CYH B 115
SER B  99
HIS B 126
 None
None
None
ALY  B 125 ( 3.6A)
 1.47A 5ycnA-2x25B:
0.0		 5ycnA-2x25B:
19.39