SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x26'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 ALA A 219
ALA A 214
LEU A 230
ILE A  31
LEU A  49
 None
 1.10A 1rg7A-2x26A:
undetectable		 1rg7A-2x26A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		5 / 11 ASP A 237
LEU A  42
ILE A  38
ILE A 262
THR A 272
 None
None
GOL  A1333 (-4.8A)
None
None
 1.01A 2w9sA-2x26A:
undetectable		 2w9sA-2x26A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		5 / 11 ASP A 237
LEU A  42
ILE A  38
ILE A 262
THR A 272
 None
None
GOL  A1333 (-4.8A)
None
None
 1.04A 2w9sB-2x26A:
undetectable		 2w9sB-2x26A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLU A  71
ALA A  91
GLY A  95
ASP A  97
LEU A  98
 None
 1.22A 3ou6C-2x26A:
undetectable		 3ou6C-2x26A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLN A  34
GLY A  66
ARG A 216
GLY A  32
ALA A 214
 None
 1.12A 3sueB-2x26A:
undetectable		 3sueB-2x26A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 GLU A 111
GLN A  34
GLY A  36
SER A  37
 None
None
None
GOL  A1333 (-4.6A)
 0.91A 4f93B-2x26A:
undetectable		 4f93B-2x26A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 TYR A 100
GLN A 306
TRP A 309
 None
 0.98A 4kn2C-2x26A:
undetectable		 4kn2C-2x26A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 SER A 264
ALA A 263
HIS A 268
LEU A 192
 None
 1.34A 5dzkf-2x26A:
undetectable
5dzkt-2x26A:
undetectable		 5dzkf-2x26A:
23.59
5dzkt-2x26A:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 223
GLY A 316
THR A 312
GLU A 220
ILE A 226
 None
 1.01A 5wz1A-2x26A:
undetectable		 5wz1A-2x26A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 223
GLY A 316
THR A 312
GLU A 220
ILE A 226
 None
 0.96A 5wz1C-2x26A:
undetectable		 5wz1C-2x26A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 223
GLY A 316
THR A 312
GLU A 220
ILE A 226
 None
 0.98A 5wz1D-2x26A:
undetectable		 5wz1D-2x26A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 223
GLY A 316
THR A 312
GLU A 220
ILE A 226
 None
 0.96A 5wz1E-2x26A:
undetectable		 5wz1E-2x26A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 223
GLY A 316
THR A 312
GLU A 220
ILE A 226
 None
 0.97A 5wz1F-2x26A:
undetectable		 5wz1F-2x26A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 223
GLY A 316
THR A 312
GLU A 220
ILE A 226
 None
 0.97A 5wz1G-2x26A:
undetectable		 5wz1G-2x26A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 223
GLY A 316
THR A 312
GLU A 220
ILE A 226
 None
 0.97A 5wz1H-2x26A:
undetectable		 5wz1H-2x26A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 ALA A  65
GLY A  66
LEU A  70
GLY A 137
 None
 0.81A 6nm4A-2x26A:
undetectable		 6nm4A-2x26A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 ASP A 204
LEU A 205
ARG A 149
 None
 0.86A 7dfrA-2x26A:
undetectable		 7dfrA-2x26A:
19.31