SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		4 / 4 GLY X   4
ASP X  58
GLY X   8
THR X  53
 None
 1.06A 1hxbB-2x27X:
undetectable		 1hxbB-2x27X:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		5 / 11 ALA X  57
TYR X 102
LEU X  99
GLN X 100
ARG X  13
 None
None
C8E  X1217 (-3.8A)
None
None
 1.28A 1iiuA-2x27X:
3.4		 1iiuA-2x27X:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		5 / 8 GLY X   4
GLY X 106
GLY X 105
MET X 104
SER X 109
 None
 1.45A 1qzzA-2x27X:
undetectable		 1qzzA-2x27X:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		4 / 7 GLY X 137
THR X 191
ILE X 180
GLY X 182
 None
 0.77A 1usqA-2x27X:
undetectable		 1usqA-2x27X:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		4 / 7 GLY X 137
THR X 191
ILE X 180
GLY X 182
 None
 0.76A 1usqF-2x27X:
undetectable		 1usqF-2x27X:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		5 / 12 MET X 141
LEU X 143
VAL X 195
ALA X 178
LEU X 129
 None
 1.05A 2japA-2x27X:
undetectable		 2japA-2x27X:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		5 / 12 MET X 141
LEU X 143
VAL X 195
ALA X 178
LEU X 129
 None
 1.00A 2japB-2x27X:
undetectable		 2japB-2x27X:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		5 / 12 MET X 141
LEU X 143
VAL X 195
ALA X 178
LEU X 129
 None
 1.05A 2japD-2x27X:
undetectable		 2japD-2x27X:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		4 / 7 GLY X 137
THR X 191
ILE X 180
GLY X 182
 None
 0.78A 2jkjE-2x27X:
undetectable		 2jkjE-2x27X:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		4 / 7 GLY X 137
THR X 191
ILE X 180
GLY X 182
 None
 0.78A 2jklA-2x27X:
undetectable		 2jklA-2x27X:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		4 / 7 GLY X 137
THR X 191
ILE X 180
GLY X 182
 None
 0.78A 2jklC-2x27X:
undetectable		 2jklC-2x27X:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		4 / 7 GLY X 137
THR X 191
ILE X 180
GLY X 182
 None
 0.79A 2jklD-2x27X:
undetectable		 2jklD-2x27X:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		4 / 7 GLY X 137
THR X 191
ILE X 180
GLY X 182
 None
 0.79A 2jklE-2x27X:
undetectable		 2jklE-2x27X:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		4 / 7 GLY X 137
THR X 191
ILE X 180
GLY X 182
 None
 0.80A 2jklF-2x27X:
undetectable		 2jklF-2x27X:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		4 / 6 PHE X 155
ARG X  13
GLN X 100
LEU X 149
 C8E  X1224 ( 4.7A)
None
None
C8E  X1223 (-4.1A)
 1.19A 2nyrA-2x27X:
undetectable		 2nyrA-2x27X:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		3 / 3 LYS X  59
SER X 109
GLN X 112
 None
 1.29A 3si7A-2x27X:
undetectable		 3si7A-2x27X:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		5 / 12 GLN X 100
GLY X 154
GLY X 115
ALA X 168
ASN X 166
 None
None
C8E  X1227 (-3.5A)
None
None
 1.11A 3t7sA-2x27X:
undetectable		 3t7sA-2x27X:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		5 / 12 GLN X 100
GLY X 154
GLY X 115
ALA X 168
ASN X 166
 None
None
C8E  X1227 (-3.5A)
None
None
 1.12A 3t7sC-2x27X:
undetectable		 3t7sC-2x27X:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		3 / 3 VAL X 201
VAL X  19
GLN X  47
 None
None
C8E  X1220 (-4.7A)
 0.71A 5qhgA-2x27X:
undetectable		 5qhgA-2x27X:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		5 / 10 ILE X  11
ASN X 108
PHE X 155
LEU X 164
ALA X 110
 None
None
C8E  X1224 ( 4.7A)
None
None
 1.19A 5y7pG-2x27X:
undetectable		 5y7pG-2x27X:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		4 / 5 PHE X  10
THR X  51
ASP X 156
ASN X 160
 None
 1.42A 5ybbA-2x27X:
undetectable		 5ybbA-2x27X:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		4 / 5 GLU X 127
PHE X 124
ASP X 145
THR X 176
 None
 1.28A 6b58A-2x27X:
undetectable		 6b58A-2x27X:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2x27 OUTER MEMBRANE
PROTEIN OPRG
(Pseudomonas
aeruginosa) 		4 / 6 SER X 184
GLY X 182
THR X 191
ILE X  28
 None
 0.89A 6f8cA-2x27X:
undetectable		 6f8cA-2x27X:
16.91