SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 ALA A 200
VAL A 194
TRP A 193
 None
 0.90A 1micA-2x2gA:
undetectable
1micB-2x2gA:
undetectable		 1micA-2x2gA:
8.55
1micB-2x2gA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 11 ALA A 125
ILE A 147
GLY A 128
ALA A 149
ILE A 150
 None
 0.95A 2b60B-2x2gA:
undetectable		 2b60B-2x2gA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 5 LEU A 209
LEU A 206
MET A 122
THR A 249
 None
 1.42A 2oaxD-2x2gA:
undetectable		 2oaxD-2x2gA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ALA A 125
ILE A 147
GLY A 128
ALA A 149
ILE A 150
 None
 0.88A 2rkfA-2x2gA:
undetectable		 2rkfA-2x2gA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ALA A 125
ILE A 147
GLY A 128
ALA A 149
ILE A 150
 None
 0.85A 2rkfB-2x2gA:
undetectable		 2rkfB-2x2gA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 7 GLY A 230
ASP A 227
TYR A 223
ARG A 226
 None
 1.10A 3arrA-2x2gA:
9.7		 3arrA-2x2gA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 7 GLY A 230
ASP A 227
TYR A 223
ARG A 226
 None
 1.15A 3aruA-2x2gA:
4.2		 3aruA-2x2gA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 7 ILE A  91
PHE A  86
LYS A  84
GLY A 120
 None
 0.92A 3em0B-2x2gA:
undetectable		 3em0B-2x2gA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 LEU A  55
LYS A  52
THR A  51
 None
 0.55A 4lj0A-2x2gA:
undetectable		 4lj0A-2x2gA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 GLU A 107
LYS A 152
ASN A 106
 None
 0.94A 4y1dA-2x2gA:
undetectable
4y1dD-2x2gA:
undetectable		 4y1dA-2x2gA:
24.58
4y1dD-2x2gA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 6 ILE A   7
PHE A 231
PHE A  60
THR A  31
 None
 1.21A 5g08A-2x2gA:
undetectable		 5g08A-2x2gA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 THR A  31
HIS A  57
ASN A  29
 None
 0.81A 5n4tA-2x2gA:
undetectable		 5n4tA-2x2gA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ALA A 140
GLU A 185
GLU A 135
ALA A 178
TYR A 210
 None
 1.09A 5n5dB-2x2gA:
2.6		 5n5dB-2x2gA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		6 / 12 ILE A 147
ALA A 149
ALA A 151
LEU A 154
ALA A 110
ILE A 208
 None
 1.48A 6a60D-2x2gA:
undetectable		 6a60D-2x2gA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 ARG A 191
ARG A 226
ASP A 227
 None
 0.96A 6d8pA-2x2gA:
undetectable		 6d8pA-2x2gA:
15.14