SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 8 TYR A 539
PHE A 422
THR A 555
LEU A 622
 None
 1.28A 1ea1A-2x2iA:
undetectable		 1ea1A-2x2iA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 7 PHE A  42
PHE A  93
VAL A  91
VAL A  77
 None
 0.88A 1epbA-2x2iA:
1.5		 1epbA-2x2iA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 7 PHE A 368
LEU A 454
ALA A 449
VAL A 445
VAL A 392
 None
 1.44A 1epbA-2x2iA:
1.5		 1epbA-2x2iA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 8 LEU A 454
ALA A 449
VAL A 445
VAL A 392
 None
 0.85A 1epbB-2x2iA:
undetectable		 1epbB-2x2iA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 10 GLY A 214
ASN A 217
LEU A 688
VAL A 691
ASN A 237
 None
 1.35A 1fpqA-2x2iA:
undetectable		 1fpqA-2x2iA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 LEU A 688
GLU A 215
SER A 648
ARG A 649
THR A 555
 None
None
None
QPS  A1050 (-3.2A)
None
 1.18A 1n5xA-2x2iA:
undetectable		 1n5xA-2x2iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 LEU A 688
GLU A 215
SER A 648
ARG A 649
THR A 555
 None
None
None
QPS  A1050 (-3.2A)
None
 1.18A 1n5xB-2x2iA:
undetectable		 1n5xB-2x2iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		3 / 3 ARG A 643
ASP A 900
ASN A1027
 None
GOL  A1541 (-3.5A)
None
 0.93A 1nbhA-2x2iA:
undetectable		 1nbhA-2x2iA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		3 / 3 ARG A 643
ASP A 900
ASN A1027
 None
GOL  A1541 (-3.5A)
None
 0.92A 1nbhD-2x2iA:
undetectable		 1nbhD-2x2iA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 7 THR A 621
TYR A 620
ASN A 616
TYR A 652
 None
 1.11A 1qzrA-2x2iA:
undetectable		 1qzrA-2x2iA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 4 THR A 424
GLY A 546
ASP A 548
ALA A 449
 None
 1.01A 1sg9A-2x2iA:
undetectable		 1sg9A-2x2iA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 8 ARG A 116
ASN A  86
SER A  88
ARG A  90
 None
 1.20A 1u1jA-2x2iA:
7.7		 1u1jA-2x2iA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 8 ILE A 695
PHE A 728
THR A 757
LEU A 758
 None
 0.93A 1v55N-2x2iA:
undetectable
1v55W-2x2iA:
undetectable		 1v55N-2x2iA:
18.50
1v55W-2x2iA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 PRO A1031
GLY A 988
GLY A 986
SER A 984
HIS A 982
 None
 1.08A 1wg8B-2x2iA:
undetectable		 1wg8B-2x2iA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 5 PRO A 726
LEU A 809
GLY A 814
LYS A 788
 None
 1.39A 1ya4C-2x2iA:
undetectable		 1ya4C-2x2iA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 6 ASP A 222
THR A 223
TYR A 224
HIS A 806
 None
 1.47A 2eimA-2x2iA:
undetectable
2eimC-2x2iA:
undetectable		 2eimA-2x2iA:
18.50
2eimC-2x2iA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 6 ASP A 222
THR A 223
TYR A 224
HIS A 806
 None
 1.45A 2einA-2x2iA:
undetectable
2einC-2x2iA:
undetectable		 2einA-2x2iA:
18.50
2einC-2x2iA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 7 GLY A 912
TYR A 841
ASN A 913
ASP A 947
 None
 1.08A 2g72B-2x2iA:
undetectable		 2g72B-2x2iA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		3 / 3 ASP A 553
ASN A 459
THR A 375
 QPS  A1050 (-3.1A)
QPS  A1050 (-3.9A)
None
 0.69A 2q63B-2x2iA:
undetectable		 2q63B-2x2iA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		3 / 3 ARG A 649
THR A 591
VAL A 556
 QPS  A1050 (-3.2A)
None
None
 0.97A 2qakA-2x2iA:
undetectable		 2qakA-2x2iA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		8 / 12 ASP A 239
ASN A 244
ASP A 412
ASP A 553
ARG A 649
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
None
QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.88A 2qmjA-2x2iA:
33.5		 2qmjA-2x2iA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 5 PRO A  69
ILE A  66
ARG A  65
ASP A  67
 None
 1.43A 2rhmB-2x2iA:
undetectable		 2rhmB-2x2iA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 5 TYR A 399
PHE A 368
VAL A 719
TYR A 732
 None
 1.42A 2x7hA-2x2iA:
undetectable		 2x7hA-2x2iA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 5 TYR A 399
PHE A 368
VAL A 719
TYR A 732
 None
 1.42A 2x7hB-2x2iA:
undetectable		 2x7hB-2x2iA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 8 ILE A 695
PHE A 728
THR A 757
LEU A 758
 None
 0.92A 3abmN-2x2iA:
undetectable
3abmW-2x2iA:
undetectable		 3abmN-2x2iA:
18.50
3abmW-2x2iA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 6 ARG A 187
PHE A  63
PHE A  93
PHE A 322
 None
 1.38A 3af3A-2x2iA:
undetectable		 3af3A-2x2iA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3COT_A_STRA1501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 7 TYR A 399
TYR A 749
GLU A 394
TYR A 732
 None
 1.50A 3cotA-2x2iA:
6.1		 3cotA-2x2iA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		3 / 3 CYH A 819
HIS A 806
PHE A 875
 None
 1.13A 3cr4X-2x2iA:
undetectable		 3cr4X-2x2iA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 6 TYR A 701
GLY A 712
THR A 668
GLU A 754
 None
 0.98A 3fpjA-2x2iA:
undetectable		 3fpjA-2x2iA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		3 / 3 GLU A 119
GLU A 122
TRP A 114
 None
 1.10A 3hrdA-2x2iA:
undetectable
3hrdE-2x2iA:
undetectable
3hrdF-2x2iA:
undetectable		 3hrdA-2x2iA:
18.07
3hrdE-2x2iA:
18.07
3hrdF-2x2iA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 7 VAL A 908
VAL A 970
LEU A1023
VAL A 983
 None
 0.83A 3hs6B-2x2iA:
undetectable		 3hs6B-2x2iA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 4 GLY A 514
VAL A 517
GLY A 374
THR A 375
 QPS  A1050 ( 4.0A)
None
None
None
 0.92A 3ib2A-2x2iA:
undetectable		 3ib2A-2x2iA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 8 TYR A  89
LEU A 143
THR A 140
GLY A 127
ILE A 147
 None
 1.08A 3jusB-2x2iA:
undetectable		 3jusB-2x2iA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 9 TYR A  89
LEU A 143
THR A 140
GLY A 127
ILE A 147
 None
 1.08A 3jusB-2x2iA:
undetectable		 3jusB-2x2iA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 LEU A 772
GLY A 722
VAL A 823
PRO A 821
GLY A 696
 None
 0.98A 3ku1H-2x2iA:
undetectable		 3ku1H-2x2iA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		8 / 12 ASP A 412
TRP A 551
ASP A 553
MET A 554
TRP A 662
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-3.2A)
QPS  A1050 (-4.8A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-4.6A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.51A 3l4wA-2x2iA:
33.4		 3l4wA-2x2iA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 6 SER A 195
PHE A 322
PHE A 151
ASN A 167
 None
 1.43A 3lskD-2x2iA:
undetectable		 3lskD-2x2iA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 6 VAL A  77
VAL A 155
ILE A 147
MET A 183
 None
 0.86A 3mssD-2x2iA:
undetectable		 3mssD-2x2iA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		3 / 3 GLN A 416
THR A 424
LEU A 409
 None
 0.71A 3ondA-2x2iA:
undetectable		 3ondA-2x2iA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		3 / 3 GLN A 416
THR A 424
LEU A 409
 None
 0.72A 3ondB-2x2iA:
undetectable		 3ondB-2x2iA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		8 / 12 ASP A 239
ASP A 412
ASP A 553
ARG A 649
TRP A 662
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.50A 3phaA-2x2iA:
26.9		 3phaA-2x2iA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		7 / 12 ASP A 239
ASP A 412
ASP A 553
ARG A 649
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.49A 3phaB-2x2iA:
31.4		 3phaB-2x2iA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		8 / 12 ASP A 239
ASP A 412
ASP A 553
ARG A 649
TRP A 662
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.47A 3phaC-2x2iA:
35.0		 3phaC-2x2iA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		8 / 12 ASP A 239
ASP A 412
ASP A 553
MET A 554
ARG A 649
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.40A 3phaD-2x2iA:
35.1		 3phaD-2x2iA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		7 / 12 ASP A 412
MET A 554
ARG A 649
TRP A 662
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.41A 3pocA-2x2iA:
35.1		 3pocA-2x2iA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		7 / 12 ASP A 412
MET A 554
ARG A 649
TRP A 662
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.38A 3pocB-2x2iA:
32.8		 3pocB-2x2iA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 PHE A 761
CYH A 723
ILE A 677
LEU A 809
ILE A 874
 None
 1.20A 3sp9A-2x2iA:
undetectable		 3sp9A-2x2iA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		8 / 12 ASP A 239
ASP A 412
ASP A 553
MET A 554
ARG A 649
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.55A 3topA-2x2iA:
32.8		 3topA-2x2iA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		9 / 12 ASP A 239
ASP A 412
ASP A 553
MET A 554
LYS A 590
ARG A 649
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 ( 4.0A)
QPS  A1050 (-3.2A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.54A 3topB-2x2iA:
32.8		 3topB-2x2iA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 5 THR A 838
GLY A 858
PRO A 835
TYR A 793
 None
 1.25A 3u8qA-2x2iA:
undetectable		 3u8qA-2x2iA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		3 / 3 TYR A 236
GLU A 215
TYR A 267
 None
 0.93A 3ug8A-2x2iA:
4.6		 3ug8A-2x2iA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		3 / 3 GLN A  74
THR A  72
ASN A  62
 None
 0.80A 3v4tE-2x2iA:
0.6		 3v4tE-2x2iA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 ASP A 239
ASN A 242
ASP A 553
MET A 554
ARG A 649
 QPS  A1050 (-2.5A)
None
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
 1.12A 3w37A-2x2iA:
32.7		 3w37A-2x2iA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		9 / 12 ASP A 239
ASN A 244
ASP A 412
ASP A 553
MET A 554
ARG A 649
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
None
QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.66A 3w37A-2x2iA:
32.7		 3w37A-2x2iA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		9 / 12 ASP A 239
ASP A 412
TRP A 551
ASP A 553
MET A 554
ARG A 649
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.8A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.53A 3w37A-2x2iA:
32.7		 3w37A-2x2iA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 5 GLU A 853
GLY A 854
TYR A 841
GLN A 839
 None
 1.38A 3w9tG-2x2iA:
undetectable		 3w9tG-2x2iA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		6 / 12 ASN A 244
ASP A 412
ASP A 553
ASP A 665
PHE A 698
HIS A 731
 None
QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.71A 3welA-2x2iA:
32.8		 3welA-2x2iA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		8 / 12 ASP A 239
ASP A 412
TRP A 551
ASP A 553
ARG A 649
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.8A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.56A 3welA-2x2iA:
32.8		 3welA-2x2iA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 ASP A 239
ASN A 242
ASP A 553
MET A 554
ARG A 649
 QPS  A1050 (-2.5A)
None
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
 1.12A 3wemA-2x2iA:
32.5		 3wemA-2x2iA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		9 / 12 ASP A 239
ASN A 244
ASP A 412
ASP A 553
MET A 554
ARG A 649
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
None
QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.65A 3wemA-2x2iA:
32.5		 3wemA-2x2iA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 ASP A 239
ASN A 242
ASP A 553
MET A 554
ARG A 649
 QPS  A1050 (-2.5A)
None
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
 1.16A 3wenA-2x2iA:
32.5		 3wenA-2x2iA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		10 / 12 ASP A 239
ASN A 244
ASP A 412
TRP A 551
ASP A 553
MET A 554
ARG A 649
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
None
QPS  A1050 (-3.2A)
QPS  A1050 (-4.8A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.72A 3wenA-2x2iA:
32.5		 3wenA-2x2iA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		8 / 12 ASP A 239
ASN A 244
ASP A 412
ASP A 553
ARG A 649
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
None
QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.70A 3weoA-2x2iA:
34.9		 3weoA-2x2iA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		8 / 12 ASP A 239
ASP A 412
TRP A 551
ASP A 553
ARG A 649
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.8A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.57A 3weoA-2x2iA:
34.9		 3weoA-2x2iA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		3 / 3 ASP A 489
ARG A 528
LYS A 487
 None
 1.17A 3wipG-2x2iA:
undetectable		 3wipG-2x2iA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 7 TRP A 535
TRP A 526
HIS A 618
TYR A 539
 None
 1.22A 4a3uA-2x2iA:
5.1		 4a3uA-2x2iA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 7 TRP A 535
TRP A 526
HIS A 618
TYR A 539
 None
 1.25A 4a3uB-2x2iA:
7.6		 4a3uB-2x2iA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 PHE A 422
LEU A 622
GLY A 630
VAL A 550
ALA A 532
 None
 1.14A 4a6dA-2x2iA:
undetectable		 4a6dA-2x2iA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 7 ILE A 147
TYR A  89
HIS A 325
VAL A 337
 None
None
None
CSO  A 336 ( 3.4A)
 1.02A 4a97A-2x2iA:
undetectable		 4a97A-2x2iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 7 ILE A 147
TYR A  89
HIS A 325
VAL A 337
 None
None
None
CSO  A 336 ( 3.4A)
 1.08A 4a97D-2x2iA:
undetectable		 4a97D-2x2iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 6 ILE A 147
TYR A  89
HIS A 325
VAL A 337
 None
None
None
CSO  A 336 ( 3.4A)
 0.99A 4a97I-2x2iA:
undetectable		 4a97I-2x2iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		6 / 12 ASP A 412
ASP A 553
ARG A 649
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.37A 4b9zA-2x2iA:
32.4		 4b9zA-2x2iA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		3 / 3 GLY A 585
SER A 583
TRP A 576
 None
 0.93A 4e7cD-2x2iA:
undetectable		 4e7cD-2x2iA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 9 VAL A 596
PRO A 594
PRO A 577
GLY A 585
TYR A  25
 None
 1.37A 4fimA-2x2iA:
undetectable		 4fimA-2x2iA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 6 TYR A 898
THR A 887
PRO A 903
PHE A1004
 None
 1.26A 4kf9A-2x2iA:
undetectable		 4kf9A-2x2iA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		3 / 3 TRP A 589
GLN A 614
THR A 591
 None
 1.02A 4m2xA-2x2iA:
undetectable		 4m2xA-2x2iA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 6 ASN A 864
GLU A 831
TYR A 865
GLU A 829
 None
 1.46A 4r87H-2x2iA:
undetectable		 4r87H-2x2iA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 7 ILE A 695
PHE A 728
THR A 757
LEU A 758
 None
 0.92A 5b1bN-2x2iA:
undetectable
5b1bW-2x2iA:
undetectable		 5b1bN-2x2iA:
18.50
5b1bW-2x2iA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 7 ILE A 695
PHE A 728
THR A 757
LEU A 758
 None
 0.92A 5b3sN-2x2iA:
undetectable
5b3sW-2x2iA:
undetectable		 5b3sN-2x2iA:
18.50
5b3sW-2x2iA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 7 GLY A 371
LEU A 511
PHE A 463
ASP A 414
 None
 0.91A 5hieB-2x2iA:
undetectable		 5hieB-2x2iA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 8 ASN A 634
PHE A 422
GLU A 474
THR A 639
 None
 1.03A 5hqaA-2x2iA:
4.8		 5hqaA-2x2iA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 8 TYR A 399
LEU A 409
LEU A 454
THR A 897
 None
 1.02A 5hs6A-2x2iA:
undetectable		 5hs6A-2x2iA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_1
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		7 / 12 ASP A 412
TRP A 551
ASP A 553
MET A 554
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-3.2A)
QPS  A1050 (-4.8A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.74A 5iefA-2x2iA:
33.7		 5iefA-2x2iA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_2
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 4 ARG A 649
TRP A 662
ASP A 694
ARG A 729
 QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
None
None
 0.40A 5iefA-2x2iA:
33.7		 5iefA-2x2iA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		8 / 12 ASP A 412
TRP A 551
ASP A 553
MET A 554
TRP A 662
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-3.2A)
QPS  A1050 (-4.8A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-4.6A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.70A 5nn6A-2x2iA:
2.2		 5nn6A-2x2iA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		8 / 12 ASP A 239
ASP A 412
TRP A 551
ASP A 553
ARG A 649
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.8A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.60A 5nn8A-2x2iA:
37.0		 5nn8A-2x2iA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 8 ARG A 201
THR A 229
GLN A 207
GLY A 209
 None
 0.93A 5nzxA-2x2iA:
undetectable		 5nzxA-2x2iA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 10 LEU A 808
GLY A 814
GLY A 811
LEU A 818
VAL A 876
 None
 1.01A 5o96G-2x2iA:
undetectable
5o96H-2x2iA:
undetectable		 5o96G-2x2iA:
12.77
5o96H-2x2iA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 GLY A 696
TYR A 751
ASN A 730
TYR A 399
PHE A 404
 None
 1.25A 5t0kA-2x2iA:
undetectable		 5t0kA-2x2iA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 11 GLY A 696
TYR A 751
ASN A 730
TYR A 399
PHE A 404
 None
 1.32A 5ttgB-2x2iA:
undetectable		 5ttgB-2x2iA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 11 ILE A 460
ILE A 631
GLY A 630
GLY A 536
LEU A 547
 None
 0.88A 5twjD-2x2iA:
undetectable		 5twjD-2x2iA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 GLY A 696
TYR A 751
ASN A 730
TYR A 399
PHE A 404
 None
 1.32A 5v9jA-2x2iA:
undetectable		 5v9jA-2x2iA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 GLY A 696
TYR A 751
ASN A 730
TYR A 399
PHE A 404
 None
 1.31A 5v9jB-2x2iA:
undetectable		 5v9jB-2x2iA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 GLY A 696
TYR A 751
ASN A 730
TYR A 399
PHE A 404
 None
 1.30A 5vscA-2x2iA:
undetectable		 5vscA-2x2iA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 GLY A 696
TYR A 751
ASN A 730
TYR A 399
PHE A 404
 None
 1.31A 5vscB-2x2iA:
undetectable		 5vscB-2x2iA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 GLY A 696
TYR A 751
ASN A 730
TYR A 399
PHE A 404
 None
 1.32A 5vsdB-2x2iA:
undetectable		 5vsdB-2x2iA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 GLY A 696
TYR A 751
ASN A 730
TYR A 399
PHE A 404
 None
 1.32A 5vseB-2x2iA:
undetectable		 5vseB-2x2iA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1401_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		7 / 10 TRP A 551
ASP A 553
ARG A 649
TRP A 662
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-4.8A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.37A 5x7pA-2x2iA:
25.7		 5x7pA-2x2iA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 8 ILE A 695
PHE A 728
THR A 757
LEU A 758
 None
 0.95A 5zcoA-2x2iA:
undetectable
5zcoJ-2x2iA:
undetectable		 5zcoA-2x2iA:
18.50
5zcoJ-2x2iA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 8 ILE A 695
PHE A 728
THR A 757
LEU A 758
 None
 0.91A 5zcpN-2x2iA:
undetectable
5zcpW-2x2iA:
undetectable		 5zcpN-2x2iA:
18.50
5zcpW-2x2iA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 5 GLN A 416
THR A 424
HIS A 450
LEU A 547
 None
 1.30A 6aphA-2x2iA:
undetectable		 6aphA-2x2iA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 11 ASP A  96
PRO A  95
ARG A 187
PRO A 270
ALA A 268
 None
 1.28A 6bm5A-2x2iA:
undetectable		 6bm5A-2x2iA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 10 LYS A 337
VAL A 327
TYR A 284
TYR A 286
GLY A 329
 CSO  A 336 ( 2.9A)
None
None
None
CSO  A 336 ( 3.9A)
 1.49A 6bsjA-2x2iA:
undetectable		 6bsjA-2x2iA:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		6 / 12 LEU A 409
GLY A 371
VAL A 719
ARG A 729
ILE A 695
ASP A 694
 None
 1.47A 6bxmA-2x2iA:
undetectable		 6bxmA-2x2iA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 HIS A 731
VAL A 663
ILE A 395
GLY A 374
ALA A 410
 QPS  A1050 (-4.3A)
None
None
None
None
 1.04A 6c2mA-2x2iA:
undetectable		 6c2mA-2x2iA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 HIS A 731
VAL A 663
ILE A 395
GLY A 374
ALA A 410
 QPS  A1050 (-4.3A)
None
None
None
None
 1.07A 6c2mB-2x2iA:
undetectable		 6c2mB-2x2iA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 8 LEU A 622
TRP A 535
THR A 626
ASN A 459
 None
None
None
QPS  A1050 (-3.9A)
 1.24A 6c71B-2x2iA:
undetectable		 6c71B-2x2iA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		7 / 12 ASP A 239
ASP A 553
MET A 554
ARG A 649
TRP A 662
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.53A 6c9xA-2x2iA:
31.2		 6c9xA-2x2iA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		7 / 12 ASP A 239
ASP A 553
MET A 554
ARG A 649
TRP A 662
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.54A 6c9xB-2x2iA:
33.4		 6c9xB-2x2iA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		7 / 12 ASP A 553
MET A 554
ARG A 649
TRP A 662
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.36A 6c9zA-2x2iA:
30.3		 6c9zA-2x2iA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		7 / 12 ASP A 239
ASP A 553
MET A 554
ARG A 649
TRP A 662
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.50A 6c9zB-2x2iA:
31.1		 6c9zB-2x2iA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		8 / 12 ASP A 412
ASP A 553
MET A 554
ARG A 649
TRP A 662
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.41A 6ca1A-2x2iA:
35.0		 6ca1A-2x2iA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		8 / 12 ASP A 412
ASP A 553
MET A 554
ARG A 649
TRP A 662
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.38A 6ca1B-2x2iA:
36.3		 6ca1B-2x2iA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		8 / 12 ASP A 412
ASP A 553
MET A 554
ARG A 649
TRP A 662
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.38A 6ca3A-2x2iA:
31.1		 6ca3A-2x2iA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		8 / 12 ASP A 412
ASP A 553
MET A 554
ARG A 649
TRP A 662
ASP A 665
PHE A 698
HIS A 731
 QPS  A1050 (-3.2A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
QPS  A1050 (-2.7A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.39A 6ca3B-2x2iA:
30.9		 6ca3B-2x2iA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 6 PHE A 184
ARG A 187
ASN A  94
ASP A  96
 None
 1.48A 6dhbA-2x2iA:
undetectable		 6dhbA-2x2iA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 LEU A 344
PHE A 138
VAL A  79
THR A 153
VAL A 145
 None
 1.10A 6djzA-2x2iA:
undetectable		 6djzA-2x2iA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_1
(-)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 THR A 774
ASP A 813
LEU A 882
GLY A 918
HIS A 812
 None
 1.35A 6f3mA-2x2iA:
undetectable		 6f3mA-2x2iA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_1
(-)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 THR A 774
ASP A 813
LEU A 882
GLY A 918
HIS A 812
 None
 1.36A 6f3mC-2x2iA:
undetectable		 6f3mC-2x2iA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_1
(-)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		5 / 12 THR A 774
ASP A 813
LEU A 882
GLY A 918
HIS A 812
 None
 1.35A 6f3nC-2x2iA:
undetectable		 6f3nC-2x2iA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 5 ARG A 717
ALA A 721
GLN A 720
ILE A 874
 None
 1.24A 6f6sA-2x2iA:
undetectable
6f6sB-2x2iA:
undetectable		 6f6sA-2x2iA:
5.26
6f6sB-2x2iA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		4 / 5 GLN A 416
THR A 424
HIS A 450
LEU A 547
 None
 1.32A 6gbnB-2x2iA:
undetectable		 6gbnB-2x2iA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		3 / 3 ASP A  15
ASP A 505
ASN A 466
 None
 0.64A 6gngB-2x2iA:
undetectable		 6gngB-2x2iA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1
(Gracilariopsis
lemaneiformis) 		3 / 3 ASP A  15
ASP A 505
ASN A 476
 None
 0.79A 6gngB-2x2iA:
undetectable		 6gngB-2x2iA:
20.43