SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 8 ILE A 176
LEU A 212
PHE A 214
PHE A 258
 None
 0.93A 2vctC-2x2uA:
undetectable		 2vctC-2x2uA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 8 ARG A 144
TYR A 146
GLU A 238
GLU A 273
 None
UNX  A1287 ( 4.6A)
None
None
 1.32A 3dh0A-2x2uA:
undetectable		 3dh0A-2x2uA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		3 / 3 PHE A 147
TYR A  36
LEU A 119
 None
 0.72A 3keeB-2x2uA:
undetectable		 3keeB-2x2uA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		3 / 3 PHE A 147
TYR A  36
LEU A 119
 None
 0.72A 3sueB-2x2uA:
undetectable		 3sueB-2x2uA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 7 ARG A 189
VAL A 254
PHE A 167
GLU A 164
 None
None
None
BU1  A1293 (-4.5A)
 1.13A 4jseA-2x2uA:
undetectable
4jseB-2x2uA:
undetectable		 4jseA-2x2uA:
21.00
4jseB-2x2uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 7 PHE A 167
GLU A 164
ARG A 189
VAL A 254
 None
BU1  A1293 (-4.5A)
None
None
 1.10A 4jseA-2x2uA:
undetectable
4jseB-2x2uA:
undetectable		 4jseA-2x2uA:
21.00
4jseB-2x2uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 6 LEU A 127
ALA A 143
SER A  32
VAL A 145
 None
 1.28A 5a6iA-2x2uA:
undetectable		 5a6iA-2x2uA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 LEU A 118
ASN A  83
LEU A  95
PHE A 147
ILE A  86
 None
 1.27A 5dv4A-2x2uA:
undetectable		 5dv4A-2x2uA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 10 GLY A 183
THR A 225
LEU A  56
GLN A  89
PHE A  66
 None
 1.07A 5fhzC-2x2uA:
undetectable		 5fhzC-2x2uA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 6 GLU A 178
ARG A 177
ARG A 231
ASP A  58
 None
 1.18A 5zw4A-2x2uA:
undetectable		 5zw4A-2x2uA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		5 / 12 PHE A 188
VAL A 193
GLN A 187
PRO A 162
ILE A 200
 None
 1.44A 6becA-2x2uA:
undetectable
6becB-2x2uA:
undetectable
6becC-2x2uA:
undetectable		 6becA-2x2uA:
17.03
6becB-2x2uA:
17.03
6becC-2x2uA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		3 / 3 LEU A  40
SER A 148
PHE A 147
 None
BU1  A1294 (-3.3A)
None
 0.59A 6fgcA-2x2uA:
undetectable		 6fgcA-2x2uA:
19.01