SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x30'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		3 / 3 VAL A  10
VAL A  18
TRP A  41
 None
 0.83A 1bdwA-2x30A:
undetectable
1bdwB-2x30A:
undetectable		 1bdwA-2x30A:
7.04
1bdwB-2x30A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		5 / 12 GLY A 222
LEU A 225
LEU A 232
LEU A 205
ALA A 219
 SO4  A1242 (-3.6A)
None
None
None
None
 1.10A 1gseB-2x30A:
undetectable		 1gseB-2x30A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		5 / 12 ILE A 168
GLY A 197
ALA A 195
GLU A  24
ASN A 178
 None
SO4  A1242 (-3.4A)
None
None
None
 1.16A 1sg9C-2x30A:
undetectable		 1sg9C-2x30A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		4 / 4 SER A 201
GLY A 197
GLY A 222
LYS A 223
 None
SO4  A1242 (-3.4A)
SO4  A1242 (-3.6A)
None
 1.33A 2y4nB-2x30A:
3.4		 2y4nB-2x30A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		5 / 12 LEU A 181
ILE A 125
VAL A 193
VAL A 185
LEU A 152
 None
 1.07A 3gwxB-2x30A:
undetectable		 3gwxB-2x30A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		4 / 4 ASP A  62
ASP A  53
GLY A  59
THR A 105
 None
None
None
SO4  A1241 (-3.4A)
 1.37A 3tl9B-2x30A:
undetectable		 3tl9B-2x30A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		5 / 11 ARG A 100
GLU A   5
LEU A   7
PRO A 192
VAL A 212
 None
 1.26A 3ua5A-2x30A:
0.0		 3ua5A-2x30A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		5 / 12 VAL A 221
VAL A 165
ALA A 235
LEU A 211
VAL A 212
 SO4  A1242 ( 4.8A)
None
None
None
None
 1.09A 4ib4A-2x30A:
undetectable		 4ib4A-2x30A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		4 / 8 LEU A 232
GLU A  47
THR A 239
ALA A 235
 None
 0.91A 4iizB-2x30A:
undetectable		 4iizB-2x30A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		5 / 12 VAL A  18
ALA A  17
VAL A  10
PHE A  58
GLY A  15
 None
 1.21A 4mm4B-2x30A:
undetectable		 4mm4B-2x30A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		5 / 9 ALA A 106
THR A 105
VAL A 101
GLY A  82
ASP A  86
 None
SO4  A1241 (-3.4A)
None
SO4  A1241 (-3.4A)
None
 1.20A 4qvnK-2x30A:
undetectable
4qvnL-2x30A:
undetectable		 4qvnK-2x30A:
22.22
4qvnL-2x30A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		5 / 9 ALA A 106
THR A 105
VAL A 101
GLY A  82
ASP A  86
 None
SO4  A1241 (-3.4A)
None
SO4  A1241 (-3.4A)
None
 1.20A 4qvnY-2x30A:
undetectable
4qvnZ-2x30A:
undetectable		 4qvnY-2x30A:
22.22
4qvnZ-2x30A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		5 / 9 ALA A 106
THR A 105
GLY A  82
GLY A  83
ASP A  86
 None
SO4  A1241 (-3.4A)
SO4  A1241 (-3.4A)
SO4  A1241 (-3.3A)
None
 1.12A 4qwuK-2x30A:
undetectable
4qwuL-2x30A:
undetectable		 4qwuK-2x30A:
22.22
4qwuL-2x30A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		5 / 9 ALA A 106
THR A 105
GLY A  82
GLY A  83
ASP A  86
 None
SO4  A1241 (-3.4A)
SO4  A1241 (-3.4A)
SO4  A1241 (-3.3A)
None
 1.15A 4qwuY-2x30A:
undetectable
4qwuZ-2x30A:
undetectable		 4qwuY-2x30A:
22.22
4qwuZ-2x30A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		6 / 12 LEU A 108
VAL A 114
ILE A 118
ALA A 119
VAL A 127
GLY A 104
 None
None
None
None
None
SO4  A1241 (-3.3A)
 1.39A 5j2tC-2x30A:
undetectable		 5j2tC-2x30A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		4 / 6 VAL A  52
VAL A 164
SER A 196
ILE A 208
 None
None
SO4  A1242 ( 4.8A)
None
 0.90A 5jw1B-2x30A:
undetectable		 5jw1B-2x30A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		4 / 5 VAL A  18
ASN A  63
ASP A  53
LEU A  54
 None
 1.27A 5m0iB-2x30A:
undetectable		 5m0iB-2x30A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		4 / 6 LEU A   6
VAL A 221
LEU A 225
VAL A 199
 None
SO4  A1242 ( 4.8A)
None
None
 0.97A 5x7zA-2x30A:
undetectable		 5x7zA-2x30A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2x30 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
coelicolor) 		4 / 6 TRP A  48
GLY A 197
ALA A 219
LEU A   7
 None
SO4  A1242 (-3.4A)
None
None
 1.02A 6fosA-2x30A:
undetectable		 6fosA-2x30A:
12.92