SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x36'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 2x36 LON PROTEASE
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 844
ILE A 816
GLY A 857
ALA A 856
LEU A 806
 None
 1.04A 1r9oA-2x36A:
undetectable		 1r9oA-2x36A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 2x36 LON PROTEASE
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 840
LEU A 864
TYR A 834
GLY A 763
 None
 0.84A 2vdbA-2x36A:
undetectable		 2vdbA-2x36A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 2x36 LON PROTEASE
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 871
VAL A 764
THR A 760
 None
 0.87A 3cyxA-2x36A:
undetectable		 3cyxA-2x36A:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPM_A_BO2A801_1
(LON PROTEASE)		 2x36 LON PROTEASE
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 ALA A 769
LEU A 778
GLY A 853
PRO A 854
SER A 855
ALA A 856
LYS A 898
 None
 0.79A 4ypmA-2x36A:
24.6		 4ypmA-2x36A:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPM_A_BO2A801_1
(LON PROTEASE)		 2x36 LON PROTEASE
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 769
THR A 771
PRO A 854
SER A 855
LYS A 898
 None
 0.75A 4ypmA-2x36A:
24.6		 4ypmA-2x36A:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2x36 LON PROTEASE
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 THR A 777
GLY A 767
GLU A 781
HIS A 843
 None
 0.86A 5c0oH-2x36A:
2.1		 5c0oH-2x36A:
25.47