SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		4 / 8 ALA A 260
GLU A 337
ALA A 279
THR A 278
 None
 0.89A 1ie4B-2x3cA:
undetectable
1ie4D-2x3cA:
undetectable		 1ie4B-2x3cA:
19.19
1ie4D-2x3cA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		4 / 8 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.81A 1v55N-2x3cA:
1.0
1v55W-2x3cA:
undetectable		 1v55N-2x3cA:
20.64
1v55W-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		4 / 8 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.80A 2eijN-2x3cA:
1.0
2eijW-2x3cA:
undetectable		 2eijN-2x3cA:
20.64
2eijW-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		4 / 7 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.80A 2eikA-2x3cA:
undetectable
2eikJ-2x3cA:
undetectable		 2eikA-2x3cA:
20.64
2eikJ-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		4 / 8 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.84A 2eikN-2x3cA:
0.5
2eikW-2x3cA:
undetectable		 2eikN-2x3cA:
20.64
2eikW-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		4 / 8 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.75A 2einA-2x3cA:
undetectable
2einJ-2x3cA:
undetectable		 2einA-2x3cA:
20.64
2einJ-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		4 / 8 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.82A 3abkA-2x3cA:
1.5
3abkJ-2x3cA:
undetectable		 3abkA-2x3cA:
20.64
3abkJ-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		4 / 8 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.83A 3abmN-2x3cA:
1.2
3abmW-2x3cA:
undetectable		 3abmN-2x3cA:
20.64
3abmW-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		4 / 8 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.81A 3asoN-2x3cA:
undetectable
3asoW-2x3cA:
undetectable		 3asoN-2x3cA:
20.64
3asoW-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		3 / 3 GLN A 106
THR A 104
ASN A  41
 SO4  A1344 (-3.3A)
None
None
 0.68A 3v4tE-2x3cA:
undetectable		 3v4tE-2x3cA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		3 / 3 GLU A  71
GLY A  74
SER A 122
 None
 0.60A 4b53B-2x3cA:
2.0		 4b53B-2x3cA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		5 / 11 SER A  34
GLY A  33
ASP A  37
ARG A  39
THR A 184
 None
SO4  A1345 (-3.0A)
SO4  A1345 ( 4.3A)
SO4  A1344 ( 3.2A)
None
 1.13A 4xt7A-2x3cA:
undetectable		 4xt7A-2x3cA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		5 / 12 ASP A 241
ALA A 242
ASP A 194
GLY A 198
THR A 282
 None
 1.21A 5hfjD-2x3cA:
undetectable		 5hfjD-2x3cA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		5 / 12 ASP A 241
ALA A 242
ASP A 194
GLY A 198
THR A 282
 None
 1.20A 5hfjH-2x3cA:
undetectable		 5hfjH-2x3cA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		3 / 3 LEU A 326
TYR A 217
SER A 225
 None
 0.82A 5iktA-2x3cA:
undetectable		 5iktA-2x3cA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		3 / 3 LYS A  92
ASP A  93
ARG A  53
 None
 0.98A 5jwaA-2x3cA:
undetectable
5jwaH-2x3cA:
undetectable		 5jwaA-2x3cA:
19.25
5jwaH-2x3cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		4 / 5 ILE A 123
PHE A  68
ARG A  39
THR A 182
 None
None
SO4  A1344 ( 3.2A)
None
 1.27A 5z84N-2x3cA:
0.7
5z84W-2x3cA:
undetectable		 5z84N-2x3cA:
20.64
5z84W-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		4 / 8 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.80A 5zcoA-2x3cA:
undetectable
5zcoJ-2x3cA:
undetectable		 5zcoA-2x3cA:
20.64
5zcoJ-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		4 / 8 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.83A 5zcpN-2x3cA:
0.6
5zcpW-2x3cA:
undetectable		 5zcpN-2x3cA:
20.64
5zcpW-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE
(Aeromonas
salmonicida) 		4 / 8 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.82A 5zcqN-2x3cA:
undetectable
5zcqW-2x3cA:
undetectable		 5zcqN-2x3cA:
20.64
5zcqW-2x3cA:
10.95