SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x3e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 176
VAL A   7
CYH A   8
ALA A  67
 None
 1.07A 1mz9D-2x3eA:
undetectable		 1mz9D-2x3eA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 176
VAL A   7
CYH A   8
ALA A  67
 None
 0.93A 1mz9E-2x3eA:
undetectable		 1mz9E-2x3eA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 133
LEU A 165
GLY A 122
GLY A 117
 None
 0.78A 1rukH-2x3eA:
undetectable
1rukL-2x3eA:
undetectable		 1rukH-2x3eA:
21.24
1rukL-2x3eA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 8 SER A  66
LEU A 134
LEU A 298
PHE A 114
SER A  12
 None
 1.46A 1wrlC-2x3eA:
undetectable
1wrlD-2x3eA:
undetectable		 1wrlC-2x3eA:
13.03
1wrlD-2x3eA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 306
VAL A   7
LEU A  10
VAL A 271
 None
 0.91A 2bdmA-2x3eA:
undetectable		 2bdmA-2x3eA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 310
GLY A 214
PHE A 210
PHE A 141
 None
 1.01A 2qx6A-2x3eA:
undetectable
2qx6B-2x3eA:
undetectable		 2qx6A-2x3eA:
22.50
2qx6B-2x3eA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 134
LEU A  97
VAL A  93
ALA A  67
GLY A 161
 None
 1.02A 2vmyA-2x3eA:
undetectable		 2vmyA-2x3eA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  46
GLY A 159
ALA A  17
ALA A  59
ASP A 158
 None
 0.98A 2yvlB-2x3eA:
undetectable		 2yvlB-2x3eA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 114
LEU A 165
VAL A   7
VAL A 318
 None
 1.08A 2zuhA-2x3eA:
undetectable		 2zuhA-2x3eA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  97
ALA A  67
ALA A  60
PHE A 114
LEU A 306
 None
 1.30A 3b0wB-2x3eA:
undetectable		 3b0wB-2x3eA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 7 ALA A   5
VAL A 163
VAL A   7
LEU A 176
 None
 0.86A 3o14A-2x3eA:
undetectable		 3o14A-2x3eA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 5 PHE A 114
LEU A 176
GLY A 122
VAL A  76
 None
 0.97A 3wrkD-2x3eA:
undetectable		 3wrkD-2x3eA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 137
ALA A 282
THR A 112
ALA A  59
VAL A 136
 None
 1.15A 4df3B-2x3eA:
undetectable		 4df3B-2x3eA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 114
LEU A 165
VAL A   7
VAL A 318
 None
 1.04A 4ek1A-2x3eA:
undetectable		 4ek1A-2x3eA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 11 HIS A 249
SER A 284
ILE A 285
GLY A 117
VAL A 318
 None
 1.23A 4fogC-2x3eA:
undetectable		 4fogC-2x3eA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 325
ALA A  63
LEU A 306
VAL A 318
LEU A 320
 None
 0.80A 4km2B-2x3eA:
undetectable		 4km2B-2x3eA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  14
LEU A 256
ALA A 288
SER A 284
LEU A 287
 None
 1.30A 4m11A-2x3eA:
undetectable		 4m11A-2x3eA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 5 ASP A  54
ASP A 106
PHE A  84
GLY A  82
 None
 1.16A 4xp6A-2x3eA:
undetectable		 4xp6A-2x3eA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 191
ALA A 251
ASN A 252
ILE A 255
 None
 1.20A 4y03B-2x3eA:
undetectable		 4y03B-2x3eA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 12 THR A 112
GLY A 137
TYR A 116
ALA A  59
ALA A 283
 None
 1.22A 5kvaA-2x3eA:
undetectable		 5kvaA-2x3eA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 12 THR A 112
GLY A 137
TYR A 116
ALA A  59
ALA A 283
 None
 1.21A 5kvaB-2x3eA:
undetectable		 5kvaB-2x3eA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 12 THR A 112
GLY A 308
VAL A 305
GLY A 185
ASP A 180
 None
 1.08A 6gngA-2x3eA:
undetectable		 6gngA-2x3eA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 6 THR A 152
LEU A 155
THR A 144
LEU A  19
 None
 1.23A 6mvxA-2x3eA:
undetectable
6mvxB-2x3eA:
undetectable
6mvxC-2x3eA:
undetectable		 6mvxA-2x3eA:
19.78
6mvxB-2x3eA:
19.78
6mvxC-2x3eA:
19.78