SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x3h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		4 / 6 LEU A  94
LEU A 104
PRO A  99
VAL A 131
 None
 1.17A 2dqyC-2x3hA:
undetectable		 2dqyC-2x3hA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		4 / 7 ALA A 322
SER A 345
THR A 346
ASN A 381
 None
 1.03A 2i91A-2x3hA:
undetectable		 2i91A-2x3hA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		4 / 7 ALA A 322
SER A 345
THR A 346
ASN A 381
 None
 1.03A 2i91B-2x3hA:
undetectable		 2i91B-2x3hA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		4 / 7 PHE A 318
PHE A 341
PHE A 349
TYR A 326
 None
 1.01A 3hggA-2x3hA:
undetectable		 3hggA-2x3hA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		5 / 10 SER A  66
LEU A 104
VAL A 136
PHE A 138
VAL A 123
 None
 1.11A 3u9fE-2x3hA:
undetectable		 3u9fE-2x3hA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		5 / 12 SER A  66
LEU A 104
VAL A 136
PHE A 138
VAL A 123
 None
 1.08A 3u9fH-2x3hA:
undetectable
3u9fI-2x3hA:
undetectable		 3u9fH-2x3hA:
16.33
3u9fI-2x3hA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		4 / 8 THR A 414
ASP A 417
TYR A 419
PHE A 399
 None
 1.07A 4drjB-2x3hA:
undetectable		 4drjB-2x3hA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		4 / 8 SER A 147
LEU A 148
CYH A 180
TYR A 199
 None
 1.20A 4j7uD-2x3hA:
undetectable		 4j7uD-2x3hA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM9_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		6 / 12 ASN A 291
SER A 212
ASN A 264
ASN A 230
THR A 210
ALA A 237
 None
 1.30A 4pm9A-2x3hA:
undetectable		 4pm9A-2x3hA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM9_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		6 / 12 SER A 212
ASN A 264
ASN A 230
THR A 210
GLY A 209
ALA A 237
 None
 1.37A 4pm9A-2x3hA:
undetectable		 4pm9A-2x3hA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		3 / 3 THR A 346
ASN A 379
SER A 380
 None
 0.64A 4tvtA-2x3hA:
undetectable		 4tvtA-2x3hA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		4 / 8 SER A 189
GLY A 159
ALA A 126
GLY A 128
 None
 0.75A 5albL-2x3hA:
undetectable		 5albL-2x3hA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		4 / 8 ASN A  70
PHE A  96
SER A 124
TYR A 151
 None
 1.38A 5amiB-2x3hA:
undetectable		 5amiB-2x3hA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		4 / 7 VAL A 246
ALA A 248
GLY A 283
VAL A 256
 None
 0.92A 5fpdB-2x3hA:
undetectable		 5fpdB-2x3hA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		4 / 4 ASN A 214
LEU A 207
SER A 185
LEU A 182
 None
 1.27A 5kb5A-2x3hA:
undetectable		 5kb5A-2x3hA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		3 / 3 THR A  90
HIS A  86
ASN A 112
 None
 0.95A 5n4tA-2x3hA:
undetectable		 5n4tA-2x3hA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		3 / 3 HIS A  86
ASN A 112
ALA A 114
 None
 0.79A 5n4tB-2x3hA:
undetectable		 5n4tB-2x3hA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		4 / 8 ILE A 165
VAL A 181
ALA A 183
TYR A 151
 None
 0.90A 6cduD-2x3hA:
undetectable
6cduE-2x3hA:
undetectable		 6cduD-2x3hA:
20.89
6cduE-2x3hA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2x3h K5 LYASE
(Escherichia
virus
K1-5) 		5 / 12 ILE A 392
THR A 314
ILE A 315
PHE A 318
PHE A 341
 None
 1.32A 6j20A-2x3hA:
undetectable		 6j20A-2x3hA:
21.31