SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		3 / 3 LEU A 222
SER A 220
ASN A  79
 None
PLP  A1211 (-3.4A)
None
 0.83A 1bx4A-2x3lA:
3.0		 1bx4A-2x3lA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		4 / 6 HIS A 398
ILE A 399
ALA A 390
VAL A 423
 None
 0.99A 1hk1A-2x3lA:
undetectable		 1hk1A-2x3lA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		5 / 12 PRO A 177
HIS A  69
ILE A 180
LEU A 152
VAL A 151
 None
 1.20A 1r30B-2x3lA:
undetectable		 1r30B-2x3lA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		5 / 12 THR A 153
ILE A 180
VAL A 205
PHE A 162
LEU A 171
 PLP  A1211 ( 4.2A)
None
None
None
None
 1.06A 1wsvA-2x3lA:
0.2		 1wsvA-2x3lA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		4 / 6 ILE A 176
TYR A 204
ILE A  99
HIS A 121
 None
 1.13A 3eteA-2x3lA:
2.3
3eteE-2x3lA:
2.5		 3eteA-2x3lA:
23.05
3eteE-2x3lA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		4 / 5 ILE A 176
TYR A 204
ILE A  99
HIS A 121
 None
 1.12A 3eteB-2x3lA:
2.3
3eteC-2x3lA:
undetectable		 3eteB-2x3lA:
23.05
3eteC-2x3lA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		4 / 7 ILE A  99
HIS A 121
ILE A 176
TYR A 204
 None
 1.14A 3eteD-2x3lA:
undetectable
3eteF-2x3lA:
2.3		 3eteD-2x3lA:
23.05
3eteF-2x3lA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		3 / 3 ILE A 408
PHE A 410
HIS A 133
 None
 0.67A 3h0aA-2x3lA:
undetectable		 3h0aA-2x3lA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		5 / 8 THR A 197
GLY A 185
ALA A 183
THR A  81
ILE A  85
 None
None
PLP  A1211 (-3.4A)
PLP  A1211 (-3.8A)
None
 1.25A 3jusB-2x3lA:
undetectable		 3jusB-2x3lA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		5 / 9 THR A 197
GLY A 185
ALA A 183
THR A  81
ILE A  85
 None
None
PLP  A1211 (-3.4A)
PLP  A1211 (-3.8A)
None
 1.25A 3jusB-2x3lA:
undetectable		 3jusB-2x3lA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		4 / 4 LYS A  68
GLN A  65
ILE A  59
LEU A  77
 None
 1.46A 3qt0A-2x3lA:
0.0		 3qt0A-2x3lA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		5 / 12 PHE A 260
GLY A  32
ALA A 257
ALA A 252
SER A 247
 None
 1.14A 3sudB-2x3lA:
undetectable		 3sudB-2x3lA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		5 / 12 HIS A 335
HIS A 187
GLY A  25
GLY A  32
GLY A 185
 None
 1.09A 4blvB-2x3lA:
3.0		 4blvB-2x3lA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		4 / 7 ASP A 337
THR A  30
LEU A 268
GLN A 191
 None
 1.10A 4ib4A-2x3lA:
undetectable		 4ib4A-2x3lA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA405_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		4 / 5 ARG A 397
LEU A 442
LYS A 437
TRP A 384
 None
 1.11A 4ifxA-2x3lA:
0.0		 4ifxA-2x3lA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA408_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		4 / 5 ARG A 397
LEU A 442
LYS A 437
TRP A 384
 None
 1.11A 4xdtA-2x3lA:
0.0		 4xdtA-2x3lA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		3 / 3 THR A  30
THR A 339
PHE A 342
 None
 0.90A 5cxvA-2x3lA:
undetectable		 5cxvA-2x3lA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		4 / 7 GLN A 309
GLY A 305
ILE A 298
TRP A 311
 None
 1.05A 5vlmC-2x3lA:
undetectable		 5vlmC-2x3lA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN
(Staphylococcus
aureus) 		4 / 8 GLN A 309
GLY A 305
ILE A 298
TRP A 311
 None
 1.03A 5vlmD-2x3lA:
undetectable		 5vlmD-2x3lA:
17.82