SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A  65
ARG A  68
ARG A  69
LEU A 111
GLU A 114
 None
 1.21A 1mj2A-2x3nA:
undetectable
1mj2B-2x3nA:
undetectable		 1mj2A-2x3nA:
14.03
1mj2B-2x3nA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 9 GLU A  65
ARG A  68
ARG A  69
LEU A 111
GLU A 114
 None
 1.19A 1mj2A-2x3nA:
undetectable		 1mj2A-2x3nA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 9 GLU A  65
ARG A  68
ARG A  69
LEU A 111
GLU A 114
 None
 1.14A 1mj2C-2x3nA:
undetectable		 1mj2C-2x3nA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A  65
ARG A  68
ARG A  69
LEU A 111
GLU A 114
 None
 1.19A 1mj2C-2x3nA:
undetectable
1mj2D-2x3nA:
undetectable		 1mj2C-2x3nA:
14.03
1mj2D-2x3nA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 11 GLU A  65
ARG A  68
ARG A  69
LEU A 111
GLU A 114
 None
 1.14A 1mjlA-2x3nA:
undetectable
1mjlB-2x3nA:
undetectable		 1mjlA-2x3nA:
14.03
1mjlB-2x3nA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 9 GLU A  65
ARG A  68
ARG A  69
LEU A 111
GLU A 114
 None
 1.21A 1mjoA-2x3nA:
undetectable		 1mjoA-2x3nA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 9 GLU A  65
ARG A  68
ARG A  69
LEU A 111
GLU A 114
 None
 1.21A 1mjoB-2x3nA:
undetectable		 1mjoB-2x3nA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A  65
ARG A  68
ARG A  69
LEU A 111
GLU A 114
 None
 1.18A 1mjoC-2x3nA:
undetectable
1mjoD-2x3nA:
undetectable		 1mjoC-2x3nA:
14.03
1mjoD-2x3nA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 9 GLU A  65
ARG A  68
ARG A  69
LEU A 111
GLU A 114
 None
 1.16A 1mjoC-2x3nA:
undetectable		 1mjoC-2x3nA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  70
GLY A  71
PRO A 104
ASP A 219
PHE A 218
 None
 1.15A 1qzzA-2x3nA:
undetectable		 1qzzA-2x3nA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 308
ASP A 311
GLY A 162
ILE A 163
ILE A  15
 FAD  A1371 (-3.6A)
None
FAD  A1371 ( 3.7A)
None
None
 0.84A 2qakA-2x3nA:
undetectable		 2qakA-2x3nA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 333
TYR A 336
GLN A 337
 None
 0.58A 2wekA-2x3nA:
3.3		 2wekA-2x3nA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 5 VAL A  31
VAL A  32
THR A 121
ARG A  30
 None
 1.22A 3bjwG-2x3nA:
1.3		 3bjwG-2x3nA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  49
ALA A  60
ALA A  64
GLY A  71
ILE A 309
 None
 1.07A 3c6gA-2x3nA:
undetectable		 3c6gA-2x3nA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 308
ASP A 311
GLY A 162
ILE A 163
ILE A  15
 FAD  A1371 (-3.6A)
None
FAD  A1371 ( 3.7A)
None
None
 0.86A 3ekxA-2x3nA:
undetectable		 3ekxA-2x3nA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 308
ASP A 311
GLY A 162
ILE A 163
 FAD  A1371 (-3.6A)
None
FAD  A1371 ( 3.7A)
None
 0.81A 3el9A-2x3nA:
undetectable		 3el9A-2x3nA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 5 ILE A 300
THR A 356
SER A 357
PHE A 364
 None
 1.22A 3snfA-2x3nA:
undetectable		 3snfA-2x3nA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  17
ALA A  21
ALA A 316
ASP A 311
ALA A 308
 None
None
None
None
FAD  A1371 (-3.6A)
 1.15A 4df3A-2x3nA:
5.0		 4df3A-2x3nA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  17
ALA A  21
ALA A 316
ASP A 311
ALA A 308
 None
None
None
None
FAD  A1371 (-3.6A)
 1.22A 4df3B-2x3nA:
4.9		 4df3B-2x3nA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 112
ILE A 116
LEU A 319
LEU A  24
 None
 1.00A 4l1wA-2x3nA:
undetectable		 4l1wA-2x3nA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ARG A  74
ALA A 259
SER A 256
ARG A 201
 None
 1.13A 4lv9A-2x3nA:
undetectable
4lv9B-2x3nA:
undetectable		 4lv9A-2x3nA:
22.61
4lv9B-2x3nA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 335
ALA A 334
ALA A 288
VAL A 158
GLN A 337
 None
 1.37A 4ryaA-2x3nA:
1.7		 4ryaA-2x3nA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 358
PHE A 190
PHE A 269
GLY A 265
PHE A 251
 None
 1.19A 5eshA-2x3nA:
undetectable		 5eshA-2x3nA:
20.61