SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x46'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_A_HSMA176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		5 / 9 SER A  28
TYR A  37
VAL A  53
ASP A 110
TRP A 121
 TRS  A1160 (-2.7A)
TRS  A1160 (-3.4A)
TRS  A1160 (-4.1A)
TRS  A1160 (-3.0A)
TRS  A1160 (-3.3A)
 0.58A 1qftA-2x46A:
8.8		 1qftA-2x46A:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_B_HSMB176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		5 / 9 SER A  28
TYR A  37
VAL A  53
ASP A 110
TRP A 121
 TRS  A1160 (-2.7A)
TRS  A1160 (-3.4A)
TRS  A1160 (-4.1A)
TRS  A1160 (-3.0A)
TRS  A1160 (-3.3A)
 0.53A 1qftB-2x46A:
17.6		 1qftB-2x46A:
25.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		6 / 6 SER A  28
TYR A  37
VAL A  53
TYR A  67
ASP A 110
TRP A 121
 TRS  A1160 (-2.7A)
TRS  A1160 (-3.4A)
TRS  A1160 (-4.1A)
TRS  A1160 (-4.7A)
TRS  A1160 (-3.0A)
TRS  A1160 (-3.3A)
 0.39A 2x45A-2x46A:
29.7		 2x45A-2x46A:
99.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		5 / 5 VAL A  53
TYR A  69
VAL A  94
ASP A  97
SER A  99
 TRS  A1160 (-4.1A)
None
None
None
None
 0.82A 2x45A-2x46A:
29.7		 2x45A-2x46A:
99.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_A_HSMA1162_1
(ALLERGEN ARG R 1)		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		4 / 4 GLU A  47
ASP A  97
HIS A 114
GLU A 119
 None
 1.04A 2x45A-2x46A:
29.7		 2x45A-2x46A:
99.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		7 / 7 SER A  28
TYR A  37
VAL A  53
TYR A  67
ILE A  92
ASP A 110
TRP A 121
 TRS  A1160 (-2.7A)
TRS  A1160 (-3.4A)
TRS  A1160 (-4.1A)
TRS  A1160 (-4.7A)
None
TRS  A1160 (-3.0A)
TRS  A1160 (-3.3A)
 0.44A 2x45B-2x46A:
29.6		 2x45B-2x46A:
99.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		4 / 4 VAL A  53
TYR A  69
VAL A  94
SER A  99
 TRS  A1160 (-4.1A)
None
None
None
 0.74A 2x45B-2x46A:
29.6		 2x45B-2x46A:
99.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		3 / 3 GLU A  47
HIS A 114
GLU A 119
 None
 0.47A 2x45B-2x46A:
29.6		 2x45B-2x46A:
99.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		7 / 7 SER A  28
TYR A  37
VAL A  53
TYR A  67
ILE A  92
ASP A 110
TRP A 121
 TRS  A1160 (-2.7A)
TRS  A1160 (-3.4A)
TRS  A1160 (-4.1A)
TRS  A1160 (-4.7A)
None
TRS  A1160 (-3.0A)
TRS  A1160 (-3.3A)
 0.45A 2x45C-2x46A:
29.4		 2x45C-2x46A:
99.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		4 / 5 VAL A  53
TYR A  69
VAL A  94
ASP A  97
 TRS  A1160 (-4.1A)
None
None
None
 0.92A 2x45C-2x46A:
29.4		 2x45C-2x46A:
99.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		4 / 5 VAL A  53
TYR A  69
VAL A  94
SER A  99
 TRS  A1160 (-4.1A)
None
None
None
 0.71A 2x45C-2x46A:
29.4		 2x45C-2x46A:
99.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		3 / 3 GLU A  47
HIS A 114
GLU A 119
 None
 0.54A 2x45C-2x46A:
29.4		 2x45C-2x46A:
99.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		3 / 3 TYR A  69
VAL A  94
THR A  82
 None
 0.83A 2ygnA-2x46A:
undetectable		 2ygnA-2x46A:
17.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BU1_A_HSMA301_1
(LIPOCALIN)		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		7 / 7 SER A  28
TYR A  37
VAL A  53
TYR A  67
ILE A  92
ASP A 110
TRP A 121
 TRS  A1160 (-2.7A)
TRS  A1160 (-3.4A)
TRS  A1160 (-4.1A)
TRS  A1160 (-4.7A)
None
TRS  A1160 (-3.0A)
TRS  A1160 (-3.3A)
 0.53A 3bu1A-2x46A:
25.6		 3bu1A-2x46A:
48.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		4 / 4 GLY A  70
VAL A  53
GLY A  83
THR A  84
 None
TRS  A1160 (-4.1A)
None
None
 0.93A 3ib2A-2x46A:
undetectable		 3ib2A-2x46A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2x46 ALLERGEN ARG R 1
(Argas
reflexus) 		4 / 6 TYR A  69
ILE A  29
VAL A  94
ALA A  85
 None
 0.85A 5cu6A-2x46A:
undetectable		 5cu6A-2x46A:
16.77