SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_A_CLWA906_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 PRO A 219
VAL A 120
TYR A 114
GLU A 111
 None
 1.33A 1m9jA-2x47A:
1.0		 1m9jA-2x47A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR A 314
GLY A 273
ILE A 303
LEU A 156
LEU A 307
 None
 1.21A 1r30A-2x47A:
undetectable		 1r30A-2x47A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR A 314
GLY A 273
ILE A 303
LEU A 156
LEU A 307
 None
 1.21A 1r30B-2x47A:
undetectable		 1r30B-2x47A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 LEU A 255
HIS A 294
LYS A 297
 None
 1.02A 1y7iA-2x47A:
undetectable		 1y7iA-2x47A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 287
LEU A 301
ILE A 267
THR A 226
ASN A 171
 None
 1.07A 2ft9A-2x47A:
undetectable		 2ft9A-2x47A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 181
HIS A 188
VAL A 170
SER A 268
GLY A 228
 None
 1.01A 2vmyA-2x47A:
undetectable		 2vmyA-2x47A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A 180
GLY A 185
HIS A 188
ILE A 187
 None
 0.69A 3d41A-2x47A:
undetectable		 3d41A-2x47A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 194
TRP A  95
ALA A 191
ALA A  98
GLY A 214
 None
 1.33A 4rn6A-2x47A:
undetectable		 4rn6A-2x47A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 305
ASP A 310
GLU A 311
LEU A 251
LEU A 318
 None
 1.09A 6ew0B-2x47A:
undetectable		 6ew0B-2x47A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 305
ASP A 310
GLU A 311
LEU A 251
LEU A 318
 None
 1.09A 6ew0D-2x47A:
undetectable		 6ew0D-2x47A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 305
ASP A 310
GLU A 311
LEU A 251
LEU A 318
 None
 1.09A 6ew0H-2x47A:
undetectable		 6ew0H-2x47A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 305
ASP A 310
GLU A 311
LEU A 251
LEU A 318
 None
 1.09A 6ew0I-2x47A:
undetectable		 6ew0I-2x47A:
16.52