SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		4 / 8 ALA A 477
LEU A 429
LEU A 470
LEU A 467
 None
 0.94A 1dvtA-2x49A:
undetectable
1dvtB-2x49A:
undetectable		 1dvtA-2x49A:
15.48
1dvtB-2x49A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		4 / 4 ILE A 658
LEU A 635
VAL A 591
ILE A 685
 None
 0.81A 1fm6D-2x49A:
undetectable		 1fm6D-2x49A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		5 / 10 VAL A 432
GLY A 464
LEU A 474
TYR A 435
ILE A 444
 None
 1.10A 1sq5D-2x49A:
undetectable		 1sq5D-2x49A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		5 / 10 LEU A 413
VAL A 398
ALA A 380
ILE A 411
VAL A 366
 None
 1.06A 2nnjA-2x49A:
undetectable		 2nnjA-2x49A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		5 / 12 GLU A 568
ARG A 651
ILE A 570
VAL A 567
GLU A 539
 None
 1.40A 2qeoA-2x49A:
undetectable		 2qeoA-2x49A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		4 / 4 LYS A 512
LEU A 509
ALA A 511
LEU A 517
 None
 1.36A 2roxA-2x49A:
undetectable		 2roxA-2x49A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X08_A_ASCA1253_0
(CYTOCHROME C
PEROXIDASE,
MITOCHONDRIAL)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		5 / 9 ALA A 638
ASP A 641
ILE A 637
TYR A 456
ARG A 475
 None
 1.43A 2x08A-2x49A:
0.0		 2x08A-2x49A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		4 / 5 ARG A 475
ASP A 641
ILE A 637
GLU A 480
 None
 1.24A 2xrzA-2x49A:
undetectable
2xrzB-2x49A:
undetectable		 2xrzA-2x49A:
22.70
2xrzB-2x49A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		5 / 9 ILE A 601
ILE A 654
MET A 657
VAL A 600
ILE A 628
 None
 1.15A 3p4wB-2x49A:
undetectable		 3p4wB-2x49A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		5 / 10 ILE A 601
ILE A 654
MET A 657
VAL A 600
ILE A 628
 None
 1.15A 3p4wD-2x49A:
undetectable		 3p4wD-2x49A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		4 / 6 ARG A 589
ARG A 468
GLY A 471
GLU A 469
 None
 1.02A 5cdqA-2x49A:
undetectable
5cdqC-2x49A:
undetectable
5cdqD-2x49A:
undetectable		 5cdqA-2x49A:
21.93
5cdqC-2x49A:
21.93
5cdqD-2x49A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		3 / 3 ARG A 431
HIS A 483
ARG A 475
 None
 0.84A 5iaoC-2x49A:
undetectable		 5iaoC-2x49A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		3 / 3 ARG A 431
HIS A 483
ARG A 475
 None
 0.86A 5iaoF-2x49A:
undetectable		 5iaoF-2x49A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		3 / 3 ARG A 431
ILE A 448
PHE A 457
 None
 0.69A 5kirA-2x49A:
0.0		 5kirA-2x49A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		5 / 10 ILE A 601
ILE A 654
MET A 657
VAL A 600
ILE A 628
 None
 1.12A 5mzrA-2x49A:
undetectable		 5mzrA-2x49A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		5 / 10 ILE A 601
ILE A 654
MET A 657
VAL A 600
ILE A 628
 None
 1.14A 5mzrC-2x49A:
undetectable		 5mzrC-2x49A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		5 / 9 ILE A 601
ILE A 654
MET A 657
VAL A 600
ILE A 628
 None
 1.12A 5mzrD-2x49A:
undetectable		 5mzrD-2x49A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		5 / 6 LEU A 478
VAL A 425
THR A 424
LEU A 379
GLU A 372
 None
 1.43A 5tudD-2x49A:
undetectable		 5tudD-2x49A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		3 / 3 ARG A 371
PHE A 423
LEU A 406
 None
HG  A1687 (-4.6A)
None
 0.87A 5veuA-2x49A:
undetectable		 5veuA-2x49A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		4 / 4 LYS A 512
LEU A 509
ALA A 511
LEU A 517
 None
 1.40A 6gnrA-2x49A:
undetectable		 6gnrA-2x49A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 2x49 INVASION PROTEIN
INVA
(Salmonella
enterica) 		4 / 4 LYS A 512
LEU A 509
ALA A 511
LEU A 517
 None
 1.41A 6gnrB-2x49A:
undetectable		 6gnrB-2x49A:
17.02