SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x4d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		4 / 6 LYS A 183
ALA A 184
LEU A 176
VAL A 186
 None
EPE  A 502 (-3.9A)
None
None
 0.95A 1sn5A-2x4dA:
undetectable		 1sn5A-2x4dA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		4 / 8 LYS A 183
ALA A 184
LEU A 176
VAL A 186
 None
EPE  A 502 (-3.9A)
None
None
 0.97A 1sn5C-2x4dA:
undetectable		 1sn5C-2x4dA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 ARG A 239
SER A 241
TYR A 158
 GOL  A 503 (-3.9A)
None
None
 1.01A 2q2hA-2x4dA:
undetectable
2q2hB-2x4dA:
undetectable		 2q2hA-2x4dA:
19.34
2q2hB-2x4dA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		5 / 11 ALA A  34
THR A 235
ALA A 258
GLY A  35
SER A  36
 None
 1.39A 2xfsB-2x4dA:
undetectable		 2xfsB-2x4dA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		5 / 11 SER A  36
THR A 235
ALA A  34
GLY A  35
ALA A 258
 None
 1.28A 2xh9A-2x4dA:
undetectable		 2xh9A-2x4dA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		5 / 10 SER A  36
THR A 235
ALA A  34
GLY A  35
ALA A 258
 None
 1.30A 2xh9B-2x4dA:
undetectable		 2xh9B-2x4dA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		5 / 10 TYR A 159
GLY A  20
ASP A 214
ASP A 242
LEU A 165
 None
MG  A 501 ( 4.7A)
MG  A 501 (-2.8A)
None
GOL  A 503 (-4.0A)
 1.25A 3ay0B-2x4dA:
undetectable		 3ay0B-2x4dA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		5 / 9 GLY A 127
ALA A 126
ASP A 125
GLY A 170
LEU A 101
 None
 0.97A 3ogpA-2x4dA:
undetectable		 3ogpA-2x4dA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		4 / 4 SER A  25
ASP A 214
ASP A 242
ALA A 160
 None
MG  A 501 (-2.8A)
None
GOL  A 503 ( 4.9A)
 1.37A 3uj6A-2x4dA:
undetectable		 3uj6A-2x4dA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 VAL A 187
GLY A 154
LYS A 189
 None
None
POP  A 500 (-2.9A)
 0.62A 4k50A-2x4dA:
undetectable		 4k50A-2x4dA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 VAL A 187
GLY A 154
LYS A 189
 None
None
POP  A 500 (-2.9A)
 0.72A 4k50E-2x4dA:
undetectable		 4k50E-2x4dA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 VAL A 187
GLY A 154
LYS A 189
 None
None
POP  A 500 (-2.9A)
 0.61A 4k50I-2x4dA:
undetectable		 4k50I-2x4dA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 SER A  25
TYR A  23
ASP A 125
 None
 0.86A 4rp8C-2x4dA:
undetectable		 4rp8C-2x4dA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		4 / 5 LYS A 183
ALA A 184
LEU A 176
VAL A 186
 None
EPE  A 502 (-3.9A)
None
None
 1.08A 5cr1A-2x4dA:
undetectable		 5cr1A-2x4dA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 LYS A 155
ASP A 168
ILE A 151
 None
 0.57A 5kc4E-2x4dA:
undetectable		 5kc4E-2x4dA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 LYS A 189
PRO A 190
LYS A 155
 POP  A 500 (-2.9A)
None
None
 1.18A 5y9yA-2x4dA:
undetectable		 5y9yA-2x4dA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 VAL A 248
GLU A 247
ILE A 216
 None
 0.66A 6f7lB-2x4dA:
undetectable		 6f7lB-2x4dA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens) 		3 / 3 ASP A 168
SER A  25
SER A  19
 None
None
POP  A 500 ( 3.9A)
 0.83A 6mxtA-2x4dA:
undetectable		 6mxtA-2x4dA:
21.11