SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 8 ALA A 228
LEU A 239
LEU A 240
LEU A 314
ALA A 310
 None
 1.28A 1e7cA-2x4gA:
undetectable		 1e7cA-2x4gA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		4 / 7 SER A  47
ARG A  51
THR A  21
ALA A  53
 None
 1.04A 1fo4B-2x4gA:
undetectable		 1fo4B-2x4gA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 194
ASP A 217
ILE A 216
VAL A 215
 None
 0.70A 1p2yA-2x4gA:
undetectable		 1p2yA-2x4gA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 213
ALA A 221
GLY A 178
ILE A 179
 None
 0.84A 2fxdB-2x4gA:
undetectable		 2fxdB-2x4gA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 178
GLY A 124
LEU A 121
ALA A 228
LEU A 240
LEU A 239
 None
 1.29A 2yqzA-2x4gA:
5.2		 2yqzA-2x4gA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 178
GLY A 124
LEU A 121
ALA A 228
LEU A 240
LEU A 239
 None
 1.27A 2yqzB-2x4gA:
5.4		 2yqzB-2x4gA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 9 SER A  47
ARG A  51
THR A  21
LEU A  41
ALA A  53
 None
 1.40A 3ax7B-2x4gA:
undetectable		 3ax7B-2x4gA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 178
GLY A 124
ALA A 310
THR A 241
LEU A 240
 None
 0.93A 3mteB-2x4gA:
4.1		 3mteB-2x4gA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 178
GLY A 124
ALA A 310
THR A 241
LEU A 240
 None
 0.97A 3p2kA-2x4gA:
3.9		 3p2kA-2x4gA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 178
GLY A 124
ALA A 310
THR A 241
LEU A 240
 None
 1.02A 3p2kB-2x4gA:
3.9		 3p2kB-2x4gA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 184
VAL A 215
VAL A 196
LEU A 305
 None
 0.95A 3rgfA-2x4gA:
undetectable		 3rgfA-2x4gA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 306
THR A 241
LEU A 239
GLU A 140
 None
 1.28A 4a3pA-2x4gA:
undetectable		 4a3pA-2x4gA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_B_QMRB1214_1
(CAPITELLA TELETA
ACHBP)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 9 ILE A 234
PHE A 108
PHE A  82
VAL A 176
TYR A 109
 None
 1.46A 4afgA-2x4gA:
0.0
4afgE-2x4gA:
0.0		 4afgA-2x4gA:
20.58
4afgE-2x4gA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  19
ARG A  30
ALA A  31
VAL A  17
ILE A  49
 None
 1.37A 4j4vA-2x4gA:
undetectable		 4j4vA-2x4gA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  52
ALA A  28
ILE A  49
GLY A  19
ILE A  32
 None
 1.02A 4nkxC-2x4gA:
undetectable		 4nkxC-2x4gA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		4 / 5 ALA A 128
TYR A 127
HIS A 243
PRO A 180
 None
 1.34A 4ze2A-2x4gA:
undetectable		 4ze2A-2x4gA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 8 ALA A 221
VAL A 183
GLY A 222
ALA A  28
GLY A  25
 None
 1.17A 4zjzA-2x4gA:
3.9		 4zjzA-2x4gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 8 ALA A 221
PRO A 180
VAL A 183
GLY A 222
ALA A  28
 None
 1.27A 4zjzB-2x4gA:
5.2		 4zjzB-2x4gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 8 ALA A 221
VAL A 183
GLY A 222
ALA A  28
GLY A  25
 None
 1.19A 4zjzB-2x4gA:
5.2		 4zjzB-2x4gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A  54
PHE A 333
GLY A 194
THR A 192
HIS A  26
 None
 1.13A 5esgA-2x4gA:
undetectable		 5esgA-2x4gA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A  54
PHE A 333
GLY A 194
THR A 192
HIS A  26
 None
 1.10A 5fsaB-2x4gA:
undetectable		 5fsaB-2x4gA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  39
LEU A  41
ALA A  31
ARG A  30
ALA A  20
 None
 1.46A 5g44A-2x4gA:
undetectable		 5g44A-2x4gA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 215
HIS A 243
LEU A 245
LEU A 326
 None
 1.07A 5hrqB-2x4gA:
undetectable
5hrqI-2x4gA:
undetectable
5hrqJ-2x4gA:
undetectable		 5hrqB-2x4gA:
5.83
5hrqI-2x4gA:
4.40
5hrqJ-2x4gA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 194
ASP A 217
ILE A 216
VAL A 215
 None
 0.79A 5ik1A-2x4gA:
undetectable		 5ik1A-2x4gA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 250
THR A 193
THR A 192
LEU A 322
 None
 1.05A 5jq7B-2x4gA:
undetectable		 5jq7B-2x4gA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 333
GLY A 194
THR A 192
LEU A  23
HIS A  26
 None
 1.22A 5v5zA-2x4gA:
undetectable		 5v5zA-2x4gA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  52
LEU A  41
GLY A  22
GLY A  25
GLY A 222
 None
 1.02A 6ce2B-2x4gA:
undetectable		 6ce2B-2x4gA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 333
GLY A 194
THR A 192
LEU A  23
HIS A  26
 None
 1.09A 6e8qA-2x4gA:
undetectable		 6e8qA-2x4gA:
13.56