SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		3 / 3 LEU A 180
PRO A 179
LEU A 326
 None
 0.52A 1hrkA-2x4lA:
undetectable		 1hrkA-2x4lA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		4 / 8 MET A 194
VAL A  87
TRP A 184
GLU A 188
 None
 1.26A 1om5A-2x4lA:
undetectable
1om5B-2x4lA:
undetectable		 1om5A-2x4lA:
21.63
1om5B-2x4lA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		4 / 6 PRO A 333
ALA A 339
GLU A 343
GLU A 340
 None
 1.16A 1qhyA-2x4lA:
undetectable		 1qhyA-2x4lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		5 / 12 SER A 189
TRP A  53
ALA A 192
VAL A 137
PRO A  69
 None
 1.12A 1vpoH-2x4lA:
undetectable
1vpoL-2x4lA:
undetectable		 1vpoH-2x4lA:
21.39
1vpoL-2x4lA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		5 / 11 GLU A 340
ALA A 341
ILE A 223
ALA A 216
ASP A 285
 None
 1.33A 2admA-2x4lA:
undetectable		 2admA-2x4lA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		5 / 11 GLU A 340
ALA A 341
ILE A 223
ALA A 216
ASP A 285
 None
 1.32A 2admB-2x4lA:
undetectable		 2admB-2x4lA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		4 / 8 TRP A 122
GLY A  94
PHE A  75
THR A 141
 None
 0.99A 2aouA-2x4lA:
undetectable		 2aouA-2x4lA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		4 / 7 TRP A 122
GLY A  94
PHE A  75
THR A 141
 None
 1.04A 2aouB-2x4lA:
undetectable		 2aouB-2x4lA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		4 / 8 TRP A 184
GLU A 188
MET A 194
VAL A  87
 None
 1.24A 3b3pA-2x4lA:
undetectable
3b3pB-2x4lA:
undetectable		 3b3pA-2x4lA:
21.81
3b3pB-2x4lA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		4 / 6 VAL A 317
LEU A 335
ILE A 301
ILE A 287
 None
 0.77A 3gcsA-2x4lA:
undetectable		 3gcsA-2x4lA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		4 / 7 ALA A 216
VAL A 225
VAL A 254
LEU A 213
 None
 0.59A 3o14A-2x4lA:
undetectable		 3o14A-2x4lA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		4 / 7 LEU A 213
VAL A 254
LEU A 180
ASP A 245
 None
 0.86A 3rgfA-2x4lA:
undetectable		 3rgfA-2x4lA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		5 / 9 PHE A 235
LEU A 309
VAL A 312
LEU A 226
ILE A 287
 None
 1.20A 3tbgD-2x4lA:
undetectable		 3tbgD-2x4lA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		4 / 8 ALA A 293
THR A 141
VAL A 171
PHE A 143
 None
 1.02A 4ltwA-2x4lA:
undetectable		 4ltwA-2x4lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		4 / 7 GLN A 181
PRO A 179
ILE A 169
ASP A  58
 None
 1.09A 4w5oA-2x4lA:
3.6		 4w5oA-2x4lA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		4 / 7 GLN A 181
PRO A 179
ILE A 169
ASP A  58
 None
 1.04A 4z4eA-2x4lA:
3.8		 4z4eA-2x4lA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		4 / 5 GLN A 181
PRO A 179
ILE A 169
ASP A  58
 None
 1.10A 4z4hA-2x4lA:
3.6		 4z4hA-2x4lA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		5 / 12 PRO A  69
LEU A 190
VAL A  78
VAL A  89
LEU A 186
 None
 1.38A 5cymA-2x4lA:
undetectable		 5cymA-2x4lA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		5 / 12 PRO A  69
LEU A 190
VAL A  78
VAL A  89
LEU A 186
 None
 1.40A 5cyqA-2x4lA:
undetectable		 5cyqA-2x4lA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		5 / 12 PRO A  69
LEU A 190
VAL A  78
VAL A  89
LEU A 186
 None
 1.39A 6eliA-2x4lA:
undetectable		 6eliA-2x4lA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN
(Streptomyces
coelicolor) 		4 / 6 TRP A  53
GLY A  86
ALA A 187
LEU A 190
 None
 1.06A 6fosA-2x4lA:
undetectable		 6fosA-2x4lA:
14.63