SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x58'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 8 ILE A 236
GLU A 214
ALA A 215
VAL A 233
 None
 0.72A 1a29A-2x58A:
undetectable		 1a29A-2x58A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 GLY A  72
VAL A  28
GLY A  60
GLY A 100
ILE A  29
 None
None
COA  A 760 ( 4.0A)
GOL  A 770 ( 4.3A)
None
 0.69A 1hxbA-2x58A:
undetectable		 1hxbA-2x58A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 8 GLY A 491
GLY A 506
LEU A 508
GLY A 516
 None
 0.70A 1jhqA-2x58A:
undetectable		 1jhqA-2x58A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 8 GLY A 491
GLY A 506
LEU A 508
GLY A 516
 None
 0.74A 1jhvA-2x58A:
undetectable		 1jhvA-2x58A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 11 PHE A 664
ARG A 657
LEU A 650
GLU A 274
ALA A 273
 None
 1.20A 1mjlA-2x58A:
undetectable
1mjlB-2x58A:
undetectable		 1mjlA-2x58A:
8.75
1mjlB-2x58A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 PHE A 511
LEU A 623
MET A 483
 None
 0.90A 1mx1D-2x58A:
undetectable		 1mx1D-2x58A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 6 PRO A  71
ALA A 132
GLU A 103
GLU A 123
 None
GOL  A 770 (-3.8A)
GOL  A 770 (-2.9A)
GOL  A 770 ( 3.5A)
 1.31A 1qhyA-2x58A:
undetectable		 1qhyA-2x58A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 7 VAL A  21
VAL A  28
TYR A   4
CYH A  51
 COA  A 760 (-4.6A)
None
None
None
 1.31A 1t46A-2x58A:
undetectable		 1t46A-2x58A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 TYR A 649
ARG A 632
GLN A 690
 None
 0.94A 1tw4A-2x58A:
undetectable		 1tw4A-2x58A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 11 ILE A 128
GLY A 134
THR A 135
GLU A 103
GLU A 251
 None
None
None
GOL  A 770 (-2.9A)
None
 1.15A 2fn1B-2x58A:
undetectable		 2fn1B-2x58A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 8 ILE A 167
ARG A 118
VAL A 119
ALA A 113
 None
COA  A 760 (-4.0A)
None
None
 0.69A 2nniA-2x58A:
undetectable		 2nniA-2x58A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 LEU A 484
TYR A 488
GLY A 491
 None
 0.63A 2ocuA-2x58A:
undetectable		 2ocuA-2x58A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 ILE A 633
ILE A 648
LEU A 678
 None
 0.40A 2prgA-2x58A:
undetectable		 2prgA-2x58A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 ILE A 633
ILE A 648
LEU A 700
 None
 0.56A 2prgA-2x58A:
undetectable		 2prgA-2x58A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 LEU A 121
GLY A 101
GLY A  99
ALA A 105
LEU A  78
 None
None
COA  A 760 ( 4.0A)
None
None
 0.96A 3dh0B-2x58A:
4.4		 3dh0B-2x58A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 5 PRO A 295
VAL A 318
GLY A 319
LYS A 361
 None
 1.14A 3elzA-2x58A:
undetectable		 3elzA-2x58A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 TYR A 487
CYH A 622
GLY A 506
ILE A 627
TYR A 624
 None
 1.27A 3iizA-2x58A:
0.4		 3iizA-2x58A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 ILE A 313
GLY A 310
ALA A 380
PRO A 435
ALA A 335
 None
 0.96A 3jb2A-2x58A:
1.5		 3jb2A-2x58A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 ILE A 128
GLY A 131
GLU A 251
THR A 135
GLU A 103
 None
GOL  A 770 (-3.7A)
None
None
GOL  A 770 (-2.9A)
 1.07A 3r75A-2x58A:
undetectable		 3r75A-2x58A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 ILE A 128
GLY A 131
GLU A 251
THR A 135
GLU A 103
 None
GOL  A 770 (-3.7A)
None
None
GOL  A 770 (-2.9A)
 1.10A 3r75B-2x58A:
undetectable		 3r75B-2x58A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 11 ILE A 128
GLY A 131
GLU A 251
THR A 135
GLU A 103
 None
GOL  A 770 (-3.7A)
None
None
GOL  A 770 (-2.9A)
 1.08A 3r76A-2x58A:
0.0		 3r76A-2x58A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 11 ILE A 128
GLY A 131
GLU A 251
THR A 135
GLU A 103
 None
GOL  A 770 (-3.7A)
None
None
GOL  A 770 (-2.9A)
 1.08A 3r76B-2x58A:
0.0		 3r76B-2x58A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 6 ALA A  61
GLU A 103
GLU A 123
ALA A 132
 GOL  A 770 (-4.1A)
GOL  A 770 (-2.9A)
GOL  A 770 ( 3.5A)
GOL  A 770 (-3.8A)
 0.31A 3r9sA-2x58A:
19.6		 3r9sA-2x58A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 6 ALA A  61
GLU A 103
GLU A 123
ALA A 132
 GOL  A 770 (-4.1A)
GOL  A 770 (-2.9A)
GOL  A 770 ( 3.5A)
GOL  A 770 (-3.8A)
 0.32A 3r9sC-2x58A:
19.9		 3r9sC-2x58A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 8 ALA A  61
GLU A 103
GLU A 123
ALA A 132
 GOL  A 770 (-4.1A)
GOL  A 770 (-2.9A)
GOL  A 770 ( 3.5A)
GOL  A 770 (-3.8A)
 0.35A 3r9tA-2x58A:
20.3		 3r9tA-2x58A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 5 ALA A  61
GLU A 103
GLU A 123
ALA A 132
 GOL  A 770 (-4.1A)
GOL  A 770 (-2.9A)
GOL  A 770 ( 3.5A)
GOL  A 770 (-3.8A)
 0.37A 3r9tC-2x58A:
20.0		 3r9tC-2x58A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 5 LEU A 106
LEU A 121
GLY A 120
GLY A  99
 None
None
None
COA  A 760 ( 4.0A)
 0.75A 3si7C-2x58A:
undetectable
3si7D-2x58A:
undetectable		 3si7C-2x58A:
18.23
3si7D-2x58A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 LEU A 508
TYR A 581
HIS A 589
ALA A 524
LEU A 526
 None
 1.30A 3tm4A-2x58A:
4.6		 3tm4A-2x58A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 LEU A 508
TYR A 581
HIS A 589
ALA A 524
LEU A 526
 None
 1.29A 3tm4B-2x58A:
4.3		 3tm4B-2x58A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 9 LEU A 405
ILE A 311
ILE A 465
GLU A 379
VAL A 299
 None
 1.44A 3tmzA-2x58A:
undetectable		 3tmzA-2x58A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 11 LEU A 102
LEU A 137
LEU A 138
GLY A 131
LEU A  75
 None
None
None
GOL  A 770 (-3.7A)
None
 1.26A 3uudA-2x58A:
undetectable		 3uudA-2x58A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 10 ALA A 666
ILE A 627
LEU A 634
ILE A 645
ASP A 646
 None
 1.25A 4dtaA-2x58A:
undetectable		 4dtaA-2x58A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 10 ALA A 666
ILE A 633
LEU A 634
ILE A 645
ASP A 646
 None
 1.29A 4dtaA-2x58A:
undetectable		 4dtaA-2x58A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 7 TYR A 602
HIS A 606
ILE A 608
PRO A 559
 None
 1.01A 4g5jA-2x58A:
undetectable		 4g5jA-2x58A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 5 VAL A 479
ARG A 482
MET A 483
GLU A 629
 None
 1.16A 4hojA-2x58A:
undetectable		 4hojA-2x58A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 5 PRO A 662
ASP A 646
ILE A 633
VAL A 470
 None
 1.23A 4hytA-2x58A:
1.1		 4hytA-2x58A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 LYS A 576
ARG A 569
TRP A 594
 None
 1.17A 4i90A-2x58A:
0.8		 4i90A-2x58A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 TYR A 487
CYH A 622
GLY A 506
ILE A 627
TYR A 624
 None
 1.29A 4jxcA-2x58A:
0.3		 4jxcA-2x58A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 7 VAL A 301
ALA A 380
LEU A 376
MET A 307
 None
 0.80A 4l9iA-2x58A:
undetectable		 4l9iA-2x58A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 6 GLU A 609
GLU A 617
ASN A 685
ARG A 556
 None
 1.10A 4ntxA-2x58A:
undetectable
4ntxC-2x58A:
0.0		 4ntxA-2x58A:
20.59
4ntxC-2x58A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 8 PRO A 501
LEU A 595
TYR A 579
LEU A 564
 None
 1.00A 4pwdA-2x58A:
undetectable		 4pwdA-2x58A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 5 ILE A 648
VAL A 470
ILE A 468
VAL A 647
 None
 0.69A 4xdtA-2x58A:
undetectable		 4xdtA-2x58A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 11 GLY A  52
ALA A 180
ILE A 181
LEU A   7
ILE A  14
 None
 1.14A 4xumB-2x58A:
undetectable		 4xumB-2x58A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 TYR A 487
CYH A 622
GLY A 506
ILE A 627
TYR A 624
 None
 1.28A 5fepA-2x58A:
undetectable		 5fepA-2x58A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 TYR A 487
CYH A 622
GLY A 506
ILE A 627
TYR A 624
 None
 1.25A 5fesA-2x58A:
undetectable		 5fesA-2x58A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 VAL A 528
SER A 410
MET A 385
 None
 0.87A 5ikqA-2x58A:
undetectable		 5ikqA-2x58A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 LEU A 137
LEU A 121
VAL A  79
GLY A  76
ALA A 132
 None
None
None
None
GOL  A 770 (-3.8A)
 1.05A 5ikrB-2x58A:
undetectable		 5ikrB-2x58A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 LEU A 508
ARG A 556
ARG A 611
GLY A 498
LEU A 495
 None
 1.24A 5m50E-2x58A:
undetectable		 5m50E-2x58A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 7 LEU A 102
GLY A 100
GLY A  60
ALA A 105
 None
GOL  A 770 ( 4.3A)
COA  A 760 ( 4.0A)
None
 0.78A 5o96C-2x58A:
undetectable		 5o96C-2x58A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 11 GLY A  95
GLY A  55
SER A 174
VAL A 177
ALA A 113
 None
 0.91A 5o96G-2x58A:
undetectable		 5o96G-2x58A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 5 LEU A 484
TYR A 649
CYH A 622
ASP A 505
 None
 1.36A 5p9iA-2x58A:
undetectable		 5p9iA-2x58A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 GLU A 123
GLY A 134
VAL A  28
LEU A  16
GLY A  60
 GOL  A 770 ( 3.5A)
None
None
None
COA  A 760 ( 4.0A)
 1.12A 5vooA-2x58A:
undetectable		 5vooA-2x58A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 GLU A 123
GLY A 134
VAL A  28
LEU A  16
GLY A  60
 GOL  A 770 ( 3.5A)
None
None
None
COA  A 760 ( 4.0A)
 1.14A 5vooB-2x58A:
undetectable		 5vooB-2x58A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 GLU A 123
GLY A 134
VAL A  28
LEU A  16
GLY A  60
 GOL  A 770 ( 3.5A)
None
None
None
COA  A 760 ( 4.0A)
 1.10A 5vooC-2x58A:
undetectable		 5vooC-2x58A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 GLU A 123
GLY A 134
VAL A  28
LEU A  16
GLY A  60
 GOL  A 770 ( 3.5A)
None
None
None
COA  A 760 ( 4.0A)
 1.16A 5vooD-2x58A:
undetectable		 5vooD-2x58A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 8 LEU A 376
VAL A 299
VAL A 296
ILE A 465
 None
 0.78A 5y9mA-2x58A:
undetectable		 5y9mA-2x58A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGH_B_PQNB843_1
(PSAB)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 9 ILE A  93
ARG A  15
ALA A  53
LEU A  16
ALA A   2
 None
 1.46A 5zghB-2x58A:
0.0		 5zghB-2x58A:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 VAL A 325
PHE A 315
ILE A 320
VAL A 296
VAL A 323
 None
 1.28A 6ap6A-2x58A:
undetectable		 6ap6A-2x58A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 VAL A 325
PHE A 315
ILE A 320
VAL A 296
VAL A 323
 None
 1.27A 6ap6B-2x58A:
undetectable		 6ap6B-2x58A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 7 ALA A 105
ILE A 151
LEU A 121
ILE A 248
 None
 0.77A 6b5vA-2x58A:
undetectable
6b5vB-2x58A:
undetectable		 6b5vA-2x58A:
8.88
6b5vB-2x58A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 ARG A 133
ARG A  33
ARG A  84
 None
 0.77A 6bplA-2x58A:
undetectable
6bplB-2x58A:
undetectable		 6bplA-2x58A:
8.52
6bplB-2x58A:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 4 ARG A 621
GLU A 617
GLU A 497
ARG A 611
 None
 1.11A 6fk2A-2x58A:
undetectable		 6fk2A-2x58A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 PRO A  71
GLY A  99
GLY A 101
VAL A  96
ALA A 132
 None
COA  A 760 ( 4.0A)
None
COA  A 760 ( 4.6A)
GOL  A 770 (-3.8A)
 1.08A 6nj9K-2x58A:
2.2		 6nj9K-2x58A:
20.49