SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x5d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 4 ILE A 141
MET A 115
VAL A 127
GLY A 143
 None
 1.40A 1e06B-2x5dA:
undetectable		 1e06B-2x5dA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 306
GLY A  48
ASP A  47
 SO4  A1401 (-4.0A)
None
None
 0.48A 1kf6A-2x5dA:
undetectable
1kf6B-2x5dA:
undetectable		 1kf6A-2x5dA:
22.95
1kf6B-2x5dA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 TRP A 331
PRO A 183
GLY A 368
GLY A 363
 None
 1.19A 1zlqA-2x5dA:
undetectable		 1zlqA-2x5dA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 163
VAL A 152
GLY A 365
 None
 0.66A 2avvE-2x5dA:
undetectable		 2avvE-2x5dA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 225
PHE A 193
VAL A 197
TYR A  87
 None
 1.26A 2wekB-2x5dA:
2.9		 2wekB-2x5dA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 SER A 225
PHE A 193
VAL A 197
TYR A  87
 None
 1.34A 2x7hA-2x5dA:
5.1		 2x7hA-2x5dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 SER A 225
PHE A 193
VAL A 197
TYR A  87
 None
 1.34A 2x7hB-2x5dA:
2.8		 2x7hB-2x5dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 SER A 225
PHE A 193
VAL A 207
TYR A  87
 None
 1.40A 2x7hB-2x5dA:
2.8		 2x7hB-2x5dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 310
VAL A 311
SER A 243
ASN A 182
TYR A 218
 None
None
PLP  A1400 ( 2.9A)
PLP  A1400 (-3.3A)
None
 1.46A 2y00A-2x5dA:
undetectable		 2y00A-2x5dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 310
VAL A 311
SER A 243
ASN A 182
TYR A 218
 None
None
PLP  A1400 ( 2.9A)
PLP  A1400 (-3.3A)
None
 1.49A 2y00B-2x5dA:
undetectable		 2y00B-2x5dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 10 ILE A  39
PHE A 394
ARG A 315
LEU A 314
ALA A 317
 None
 1.16A 3lw5B-2x5dA:
undetectable		 3lw5B-2x5dA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 ILE A  76
PRO A  77
SER A  73
GLY A  75
 None
 1.18A 3tkdB-2x5dA:
undetectable		 3tkdB-2x5dA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 225
TYR A  87
PRO A 180
 None
 0.88A 4k8cA-2x5dA:
2.9		 4k8cA-2x5dA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 225
TYR A  87
PRO A 180
 None
 0.85A 4kahA-2x5dA:
2.9		 4kahA-2x5dA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 225
TYR A  87
PRO A 180
 None
 0.87A 4kahB-2x5dA:
3.2		 4kahB-2x5dA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 225
TYR A  87
PRO A 180
 None
 0.87A 4kanA-2x5dA:
2.8		 4kanA-2x5dA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 225
TYR A  87
PRO A 180
 None
 0.88A 4kanB-2x5dA:
undetectable		 4kanB-2x5dA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 225
TYR A  87
PRO A 180
 None
 0.87A 4kbeA-2x5dA:
3.0		 4kbeA-2x5dA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 225
TYR A  87
PRO A 180
 None
 0.91A 4kbeB-2x5dA:
2.9		 4kbeB-2x5dA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  41
PRO A 324
SER A 327
VAL A 321
 None
 1.08A 4klrA-2x5dA:
undetectable		 4klrA-2x5dA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 225
TYR A  87
PRO A 180
 None
 0.84A 4lbgA-2x5dA:
2.2		 4lbgA-2x5dA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 225
TYR A  87
PRO A 180
 None
 0.85A 4lbgB-2x5dA:
2.2		 4lbgB-2x5dA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 ILE A 226
ARG A 195
LEU A 161
MET A 175
 None
 0.92A 4xtaB-2x5dA:
undetectable		 4xtaB-2x5dA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 237
LEU A 262
ILE A 125
MET A 115
LEU A 177
 None
 1.04A 5og9B-2x5dA:
undetectable		 5og9B-2x5dA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 307
ARG A 306
PHE A 374
ILE A  39
 None
SO4  A1401 (-4.0A)
None
None
 1.10A 5vceA-2x5dA:
undetectable		 5vceA-2x5dA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 370
GLY A 363
ASN A 129
SER A 148
VAL A 152
 None
 0.86A 6bqgA-2x5dA:
undetectable		 6bqgA-2x5dA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 341
SER A 343
PHE A 346
 None
 0.65A 6fgcA-2x5dA:
undetectable		 6fgcA-2x5dA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2x5d PROBABLE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 MET A 256
GLY A 106
ALA A 112
LEU A 111
 None
SO4  A1402 (-3.2A)
None
None
 0.98A 6fosA-2x5dA:
undetectable		 6fosA-2x5dA:
11.97