SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2x5n 26S PROTEASOME
REGULATORY SUBUNIT
RPN10
(Schizosaccharomy
ces
pombe) 		6 / 12 LEU A 125
LEU A 128
PHE A 156
MET A 132
ILE A 118
LEU A  96
 None
 1.44A 2pnjA-2x5nA:
3.0		 2pnjA-2x5nA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 2x5n 26S PROTEASOME
REGULATORY SUBUNIT
RPN10
(Schizosaccharomy
ces
pombe) 		5 / 12 ASP A 158
ILE A 126
VAL A 114
ILE A  54
ALA A 160
 None
 1.20A 3ohtA-2x5nA:
1.4
3ohtB-2x5nA:
undetectable		 3ohtA-2x5nA:
18.86
3ohtB-2x5nA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2x5n 26S PROTEASOME
REGULATORY SUBUNIT
RPN10
(Schizosaccharomy
ces
pombe) 		4 / 8 SER A 165
SER A 163
ALA A 160
SER A 162
 None
 0.92A 4ikjA-2x5nA:
undetectable
4ikjB-2x5nA:
undetectable		 4ikjA-2x5nA:
22.16
4ikjB-2x5nA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2x5n 26S PROTEASOME
REGULATORY SUBUNIT
RPN10
(Schizosaccharomy
ces
pombe) 		4 / 8 ALA A 160
SER A 162
SER A 165
SER A 163
 None
 0.91A 4ikkA-2x5nA:
undetectable
4ikkB-2x5nA:
undetectable		 4ikkA-2x5nA:
22.16
4ikkB-2x5nA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2x5n 26S PROTEASOME
REGULATORY SUBUNIT
RPN10
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP A  20
SER A 116
GLY A 145
ALA A  28
 None
 0.91A 4m48A-2x5nA:
undetectable		 4m48A-2x5nA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2x5n 26S PROTEASOME
REGULATORY SUBUNIT
RPN10
(Schizosaccharomy
ces
pombe) 		4 / 8 GLY A 188
GLN A 189
SER A 185
SER A 179
 None
 0.99A 4ws1A-2x5nA:
undetectable		 4ws1A-2x5nA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2x5n 26S PROTEASOME
REGULATORY SUBUNIT
RPN10
(Schizosaccharomy
ces
pombe) 		4 / 6 ASP A  43
ARG A 101
ASN A  47
GLN A 106
 None
 1.30A 5l6eA-2x5nA:
2.3		 5l6eA-2x5nA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 2x5n 26S PROTEASOME
REGULATORY SUBUNIT
RPN10
(Schizosaccharomy
ces
pombe) 		5 / 12 ARG A 109
ILE A 157
PHE A 156
ALA A 160
GLY A  90
 None
 1.06A 5veuH-2x5nA:
undetectable		 5veuH-2x5nA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2x5n 26S PROTEASOME
REGULATORY SUBUNIT
RPN10
(Schizosaccharomy
ces
pombe) 		6 / 12 ILE A 157
ALA A 159
LEU A 125
PHE A 156
ILE A  91
ILE A 139
 None
 1.49A 5z6kA-2x5nA:
2.6		 5z6kA-2x5nA:
20.00