SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x5q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 2x5q SSO1986
(Sulfolobus
solfataricus) 		3 / 3 ASP A  49
HIS A  53
ASP A 180
 None
 0.78A 1nw5A-2x5qA:
undetectable		 1nw5A-2x5qA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2x5q SSO1986
(Sulfolobus
solfataricus) 		5 / 12 THR A  16
PRO A 122
SER A 189
TYR A 187
ILE A  63
 None
 1.24A 1z9hA-2x5qA:
undetectable		 1z9hA-2x5qA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2x5q SSO1986
(Sulfolobus
solfataricus) 		5 / 12 THR A  16
PRO A 122
SER A 189
TYR A 187
ILE A  63
 None
 1.23A 1z9hB-2x5qA:
undetectable		 1z9hB-2x5qA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2x5q SSO1986
(Sulfolobus
solfataricus) 		5 / 12 THR A  16
PRO A 122
SER A 189
TYR A 187
ILE A  63
 None
 1.23A 1z9hC-2x5qA:
undetectable		 1z9hC-2x5qA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2x5q SSO1986
(Sulfolobus
solfataricus) 		5 / 12 THR A  16
PRO A 122
SER A 189
TYR A 187
ILE A  63
 None
 1.22A 1z9hD-2x5qA:
undetectable		 1z9hD-2x5qA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2x5q SSO1986
(Sulfolobus
solfataricus) 		4 / 8 LEU A 158
TYR A 162
ILE A  83
ILE A  55
 None
 0.79A 2bu8A-2x5qA:
undetectable		 2bu8A-2x5qA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 2x5q SSO1986
(Sulfolobus
solfataricus) 		4 / 8 GLY A  30
GLY A  68
ILE A  63
THR A  16
 None
 0.67A 3d41A-2x5qA:
undetectable		 3d41A-2x5qA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 2x5q SSO1986
(Sulfolobus
solfataricus) 		4 / 8 ILE A  29
SER A  31
SER A  66
GLY A  30
 None
 0.92A 3lslA-2x5qA:
undetectable
3lslD-2x5qA:
undetectable		 3lslA-2x5qA:
20.07
3lslD-2x5qA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 2x5q SSO1986
(Sulfolobus
solfataricus) 		5 / 9 TYR A  37
ILE A  27
ILE A  35
VAL A 157
ILE A  15
 None
 1.05A 3p4wB-2x5qA:
undetectable		 3p4wB-2x5qA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 2x5q SSO1986
(Sulfolobus
solfataricus) 		5 / 10 TYR A  37
ILE A  27
ILE A  35
VAL A 157
ILE A  15
 None
 1.05A 3p4wD-2x5qA:
undetectable		 3p4wD-2x5qA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 2x5q SSO1986
(Sulfolobus
solfataricus) 		5 / 10 TYR A  37
ILE A  27
ILE A  35
VAL A 157
ILE A  15
 None
 1.05A 3p4wE-2x5qA:
undetectable		 3p4wE-2x5qA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 2x5q SSO1986
(Sulfolobus
solfataricus) 		5 / 10 VAL A 154
TYR A 178
TYR A 162
ILE A  47
ILE A  83
 None
 1.10A 3vriA-2x5qA:
undetectable
3vriC-2x5qA:
undetectable		 3vriA-2x5qA:
19.50
3vriC-2x5qA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 2x5q SSO1986
(Sulfolobus
solfataricus) 		5 / 12 VAL A 154
TYR A 178
TYR A 162
ILE A  47
ILE A  83
 None
 1.10A 3vrjA-2x5qA:
undetectable
3vrjC-2x5qA:
undetectable		 3vrjA-2x5qA:
19.50
3vrjC-2x5qA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2x5q SSO1986
(Sulfolobus
solfataricus) 		5 / 12 VAL A  11
ILE A 161
LEU A 158
VAL A 181
ILE A 153
 None
 0.92A 5mueA-2x5qA:
undetectable		 5mueA-2x5qA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2x5q SSO1986
(Sulfolobus
solfataricus) 		5 / 9 ILE A  29
VAL A 157
GLU A  65
LEU A 145
ILE A  15
 None
 1.43A 5mzpA-2x5qA:
undetectable		 5mzpA-2x5qA:
18.64