SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x5r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2x5r HYPOTHETICAL PROTEIN
ORF126
(Pyrobaculum
spherical
virus) 		4 / 8 THR A 117
ASP A 110
PHE A  43
ASN A  91
 ZN  A1127 ( 4.0A)
ZN  A1127 (-2.7A)
None
None
 1.01A 1lhvA-2x5rA:
undetectable		 1lhvA-2x5rA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 2x5r HYPOTHETICAL PROTEIN
ORF126
(Pyrobaculum
spherical
virus) 		5 / 11 LEU A  61
ALA A  65
ASN A 100
ALA A  97
VAL A  41
 None
 1.08A 3e22B-2x5rA:
undetectable		 3e22B-2x5rA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 2x5r HYPOTHETICAL PROTEIN
ORF126
(Pyrobaculum
spherical
virus) 		5 / 11 LEU A  61
ALA A  65
ASN A 100
ALA A  97
VAL A  41
 None
 1.09A 3e22D-2x5rA:
undetectable		 3e22D-2x5rA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2x5r HYPOTHETICAL PROTEIN
ORF126
(Pyrobaculum
spherical
virus) 		5 / 12 LEU A  61
ALA A  65
ASN A 100
ALA A  97
VAL A  41
 None
 1.01A 4x1iB-2x5rA:
undetectable		 4x1iB-2x5rA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2x5r HYPOTHETICAL PROTEIN
ORF126
(Pyrobaculum
spherical
virus) 		5 / 12 LEU A  61
ALA A  65
ASN A 100
ALA A  97
VAL A  41
 None
 0.94A 4x1yB-2x5rA:
undetectable		 4x1yB-2x5rA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2x5r HYPOTHETICAL PROTEIN
ORF126
(Pyrobaculum
spherical
virus) 		5 / 12 LEU A  61
ALA A  65
ASN A 100
ALA A  97
VAL A  41
 None
 1.03A 4x20B-2x5rA:
undetectable		 4x20B-2x5rA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 2x5r HYPOTHETICAL PROTEIN
ORF126
(Pyrobaculum
spherical
virus) 		5 / 11 VAL A  55
VAL A  21
VAL A  53
PHE A  43
TYR A 104
 None
 1.11A 5e4dB-2x5rA:
undetectable		 5e4dB-2x5rA:
20.86