SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D1G_B_MTXB171_1 (DIHYDROFOLATE REDUCTASE)	2x5t	ORF 131 (Sulfolobus islandicus rod-shaped virus 1)	5 / 12	VAL A 36 ARG A 33 ILE A 65 LEU A 73 ILE A 53	None	1.17A	1d1gB-2x5tA: undetectable	1d1gB-2x5tA: 22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WEY_A_EV1A1771_1 (CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE)	2x5t	ORF 131 (Sulfolobus islandicus rod-shaped virus 1)	5 / 12	LEU A 87 LEU A 51 VAL A 36 ILE A 7 PHE A 79	None None None None MLI A1096 (-4.7A)	1.18A	2weyA-2x5tA: undetectable	2weyA-2x5tA: 15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABL_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	2x5t	ORF 131 (Sulfolobus islandicus rod-shaped virus 1)	4 / 7	ILE A 8 LEU A 4 THR A 52 LEU A 51	None MLI A1096 (-3.9A) None None	1.06A	3ablA-2x5tA: undetectable 3ablJ-2x5tA: undetectable	3ablA-2x5tA: 10.04 3ablJ-2x5tA: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MK4_B_CHDB504_0 (FERROCHELATASE, MITOCHONDRIAL)	2x5t	ORF 131 (Sulfolobus islandicus rod-shaped virus 1)	3 / 3	LEU A 73 ILE A 34 ARG A 33	None	0.63A	4mk4B-2x5tA: undetectable	4mk4B-2x5tA: 13.41

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1D1G_B_MTXB171_1","DIHYDROFOLATE REDUCTASE","2x5t","ORF 131","Sulfolobus islandicus rod-shaped virus 1",5,"VAL A  36;ARG A  33;ILE A  65;LEU A  73;ILE A  53","None","1.17A","1d1gB-2x5tA:undetectable","1d1gB-2x5tA:22.35"],["2WEY_A_EV1A1771_1","CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE","2x5t","ORF 131","Sulfolobus islandicus rod-shaped virus 1",5,"LEU A  87;LEU A  51;VAL A  36;ILE A   7;PHE A  79","None;None;None;None;MLI A1096 (-4.7A)","1.18A","2weyA-2x5tA:undetectable","2weyA-2x5tA:15.22"],["3ABL_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 1","2x5t","ORF 131","Sulfolobus islandicus rod-shaped virus 1",4,"ILE A   8;LEU A   4;THR A  52;LEU A  51","None;MLI A1096 (-3.9A);None;None","1.06A","3ablA-2x5tA:undetectable;3ablJ-2x5tA:undetectable","3ablA-2x5tA:10.04;3ablJ-2x5tA:19.57"],["4MK4_B_CHDB504_0","FERROCHELATASE, MITOCHONDRIAL","2x5t","ORF 131","Sulfolobus islandicus rod-shaped virus 1",3,"LEU A  73;ILE A  34;ARG A  33","None","0.63A","4mk4B-2x5tA:undetectable","4mk4B-2x5tA:13.41"]]