SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 8 PHE A  27
TYR A  61
GLY A  10
GLY A   9
 None
None
GTP  A 601 (-3.3A)
GTP  A 601 (-3.1A)
 0.75A 1ekjE-2x60A:
undetectable
1ekjF-2x60A:
undetectable		 1ekjE-2x60A:
20.54
1ekjF-2x60A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 7 HIS A 110
LEU A   7
ASP A 109
PHE A 193
 None
GTP  A 601 (-3.7A)
GTP  A 601 ( 3.7A)
None
 1.27A 1ismB-2x60A:
undetectable		 1ismB-2x60A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 11 GLU A  47
ARG A  38
LEU A  69
GLU A  71
LEU A  45
 None
 1.31A 1mjqA-2x60A:
undetectable
1mjqB-2x60A:
undetectable		 1mjqA-2x60A:
15.92
1mjqB-2x60A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 LEU A 187
SER A 190
MET A 192
GLU A 257
PHE A 256
 None
 1.33A 1s2aA-2x60A:
undetectable		 1s2aA-2x60A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 7 THR A 310
PRO A 311
LEU A  28
THR A  20
 None
 0.85A 2vl2B-2x60A:
undetectable		 2vl2B-2x60A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 LEU A 135
ASP A 100
VAL A 103
THR A  94
 None
 1.20A 3cyxB-2x60A:
undetectable		 3cyxB-2x60A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 GLU A 203
VAL A 204
CYH A 207
 None
 0.91A 3fbxA-2x60A:
undetectable		 3fbxA-2x60A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ASN A  85
ASP A 239
ARG A  43
 MG  A 602 (-4.4A)
None
None
 0.69A 3k13A-2x60A:
undetectable		 3k13A-2x60A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 LEU A 187
SER A 237
PHE A 168
TYR A 151
VAL A 165
 None
 1.45A 5d0yA-2x60A:
undetectable		 5d0yA-2x60A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_B_FOLB201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 LEU A 187
SER A 237
PHE A 168
TYR A 151
VAL A 165
 None
 1.46A 5d0yB-2x60A:
undetectable		 5d0yB-2x60A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 VAL A  56
GLU A  80
GLY A  93
LEU A   5
 GTP  A 601 (-4.0A)
GTP  A 601 (-2.9A)
None
None
 1.29A 5g5gC-2x60A:
undetectable		 5g5gC-2x60A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 7 PHE A 168
VAL A 238
ASP A 239
VAL A 242
 None
 0.81A 5ik1A-2x60A:
undetectable		 5ik1A-2x60A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.65A 5qgjA-2x60A:
undetectable		 5qgjA-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.68A 5qglA-2x60A:
undetectable		 5qglA-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.67A 5qgmA-2x60A:
undetectable		 5qgmA-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.62A 5qgnA-2x60A:
undetectable		 5qgnA-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.72A 5qguA-2x60A:
undetectable		 5qguA-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.68A 5qgvA-2x60A:
undetectable		 5qgvA-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.71A 5qgwA-2x60A:
undetectable		 5qgwA-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.69A 5qgxA-2x60A:
undetectable		 5qgxA-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.69A 5qh1A-2x60A:
undetectable		 5qh1A-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.68A 5qh4A-2x60A:
undetectable		 5qh4A-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.64A 5qh5A-2x60A:
undetectable		 5qh5A-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.68A 5qh6A-2x60A:
undetectable		 5qh6A-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.69A 5qh9A-2x60A:
undetectable		 5qh9A-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.69A 5qhcA-2x60A:
undetectable		 5qhcA-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.71A 5qheA-2x60A:
undetectable		 5qheA-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.68A 5qhfA-2x60A:
undetectable		 5qhfA-2x60A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 VAL A 249
VAL A 165
GLN A 167
 None
 0.64A 5qhgA-2x60A:
undetectable		 5qhgA-2x60A:
21.79