SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		4 / 7 LEU A  86
HIS A  85
ASN A 127
TYR A 185
 None
 0.84A 1afsA-2x63A:
undetectable		 1afsA-2x63A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		4 / 7 LEU A  86
HIS A  85
ASN A 127
TYR A 185
 None
 0.85A 1afsB-2x63A:
undetectable		 1afsB-2x63A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWJ_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		5 / 9 PHE A  35
TYR A  34
THR A  61
THR A 166
ASP A 242
 None
 1.44A 1iwjA-2x63A:
undetectable		 1iwjA-2x63A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		5 / 10 PHE A  35
TYR A  34
THR A  61
THR A 166
ASP A 242
 None
 1.42A 1o76A-2x63A:
undetectable		 1o76A-2x63A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		4 / 8 ASN A 116
GLN A 111
ASN A  80
ASP A 107
 None
 1.26A 1rs6B-2x63A:
undetectable		 1rs6B-2x63A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		4 / 7 PHE A  35
TYR A  34
THR A  61
ASP A 242
 None
 1.07A 1t85A-2x63A:
undetectable		 1t85A-2x63A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		5 / 10 PHE A  35
TYR A  34
THR A  61
THR A 166
ASP A 242
 None
 1.43A 2qboA-2x63A:
undetectable		 2qboA-2x63A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		5 / 12 PHE A 178
LEU A 171
ALA A  51
SER A  79
SER A 132
 None
None
None
None
C  A1261 (-2.8A)
 1.43A 3apvA-2x63A:
undetectable		 3apvA-2x63A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		5 / 9 PHE A  35
TYR A  34
THR A  61
THR A 166
ASP A 242
 None
 1.42A 3cppA-2x63A:
0.0		 3cppA-2x63A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		6 / 12 ILE A 153
GLY A 152
GLY A   8
PRO A  11
ALA A 163
TYR A  18
 C  A1261 (-4.3A)
None
C  A1261 (-3.0A)
C  A1261 (-4.8A)
None
None
 1.25A 3jayA-2x63A:
undetectable		 3jayA-2x63A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_A_CLMA221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		5 / 9 TYR A  96
PHE A  95
LEU A 143
PHE A  49
VAL A 139
 None
 1.42A 3u9fA-2x63A:
0.0		 3u9fA-2x63A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		4 / 5 TYR A 162
SER A 132
ASP A 242
ILE A 243
 C  A1261 (-4.2A)
C  A1261 (-2.8A)
None
None
 1.11A 3uj7B-2x63A:
undetectable		 3uj7B-2x63A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		5 / 12 PRO A  22
LEU A 211
CYH A 137
ILE A   5
PHE A  49
 None
 1.28A 4a79A-2x63A:
undetectable		 4a79A-2x63A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		4 / 8 ASP A 154
ILE A 153
GLY A 152
SER A  79
 None
C  A1261 (-4.3A)
None
None
 0.80A 4acbB-2x63A:
undetectable
4acbC-2x63A:
undetectable		 4acbB-2x63A:
20.49
4acbC-2x63A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		5 / 9 PHE A  35
TYR A  34
THR A  61
THR A 166
ASP A 242
 None
 1.47A 4ek1B-2x63A:
undetectable		 4ek1B-2x63A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		4 / 7 ASN A 116
GLN A 111
ASN A  80
ASP A 107
 None
 1.33A 4kcnB-2x63A:
undetectable		 4kcnB-2x63A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		5 / 8 PHE A  35
TYR A  34
THR A  61
THR A 166
ASP A 242
 None
 1.45A 4l4aA-2x63A:
undetectable		 4l4aA-2x63A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		4 / 8 PHE A  35
TYR A  34
THR A  61
ASP A 242
 None
 1.11A 4l4dA-2x63A:
undetectable		 4l4dA-2x63A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		4 / 7 PHE A  35
TYR A  34
THR A  61
ASP A 242
 None
 1.06A 4l4gA-2x63A:
undetectable		 4l4gA-2x63A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		5 / 9 ILE A 194
PHE A 220
VAL A 134
THR A 131
ILE A 153
 None
None
None
C  A1261 (-3.0A)
C  A1261 (-4.3A)
 1.43A 5lg3C-2x63A:
undetectable		 5lg3C-2x63A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		5 / 9 ILE A 194
PHE A 220
VAL A 134
THR A 131
ILE A 153
 None
None
None
C  A1261 (-3.0A)
C  A1261 (-4.3A)
 1.47A 5lg3D-2x63A:
undetectable		 5lg3D-2x63A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		5 / 9 ALA A 196
ILE A 148
LEU A 208
ILE A 206
ILE A 141
 None
 0.96A 5nunA-2x63A:
undetectable		 5nunA-2x63A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		5 / 10 PHE A 155
ALA A 218
LEU A 217
ILE A 141
LEU A 112
 None
 1.19A 5oy01-2x63A:
undetectable
5oy07-2x63A:
undetectable		 5oy01-2x63A:
17.33
5oy07-2x63A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		4 / 8 ASN A 116
GLN A 111
ASN A  80
ASP A 107
 None
 1.29A 5vunB-2x63A:
undetectable		 5vunB-2x63A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		4 / 8 ASN A 116
GLN A 111
ASN A  80
ASP A 107
 None
 1.30A 5vuoB-2x63A:
undetectable		 5vuoB-2x63A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		4 / 8 ASN A 116
GLN A 111
ASN A  80
ASP A 107
 None
 1.29A 6auuB-2x63A:
undetectable		 6auuB-2x63A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE
(Campylobacter
jejuni) 		5 / 12 LEU A 171
LEU A  54
ALA A  51
SER A  79
GLY A   8
 None
None
None
None
C  A1261 (-3.0A)
 0.94A 6b0iB-2x63A:
undetectable		 6b0iB-2x63A:
15.48