SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x64'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 2x64 GLUTATHIONE-S-TRANSF
ERASE
(Xylella
fastidiosa) 		3 / 3 ALA A 191
VAL A 195
TRP A  20
 None
 0.89A 1nt6A-2x64A:
undetectable		 1nt6A-2x64A:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 2x64 GLUTATHIONE-S-TRANSF
ERASE
(Xylella
fastidiosa) 		3 / 3 ALA A 191
VAL A 195
TRP A  20
 None
 0.89A 1nt6B-2x64A:
undetectable		 1nt6B-2x64A:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 2x64 GLUTATHIONE-S-TRANSF
ERASE
(Xylella
fastidiosa) 		3 / 3 TRP A  20
ALA A 191
VAL A 195
 None
 0.79A 2izqA-2x64A:
undetectable
2izqB-2x64A:
undetectable		 2izqA-2x64A:
9.09
2izqB-2x64A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 2x64 GLUTATHIONE-S-TRANSF
ERASE
(Xylella
fastidiosa) 		5 / 12 ALA A 198
GLU A 202
LEU A 199
LEU A  12
GLY A 157
 None
 0.97A 2jfaB-2x64A:
undetectable		 2jfaB-2x64A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 2x64 GLUTATHIONE-S-TRANSF
ERASE
(Xylella
fastidiosa) 		5 / 12 ILE A  16
TYR A 163
THR A 165
LEU A 166
LEU A 182
 None
 1.36A 2mjiA-2x64A:
undetectable		 2mjiA-2x64A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2x64 GLUTATHIONE-S-TRANSF
ERASE
(Xylella
fastidiosa) 		5 / 12 MET A 189
ALA A  13
PHE A 186
PHE A 185
GLY A   8
 None
 1.10A 3aobC-2x64A:
undetectable		 3aobC-2x64A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2x64 GLUTATHIONE-S-TRANSF
ERASE
(Xylella
fastidiosa) 		5 / 12 MET A 189
ALA A  13
PHE A 186
PHE A 185
GLY A   8
 None
 1.07A 3aodC-2x64A:
undetectable		 3aodC-2x64A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2x64 GLUTATHIONE-S-TRANSF
ERASE
(Xylella
fastidiosa) 		4 / 7 LEU A  30
ALA A  51
THR A  60
VAL A  58
 None
 1.01A 3d2tA-2x64A:
undetectable		 3d2tA-2x64A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 2x64 GLUTATHIONE-S-TRANSF
ERASE
(Xylella
fastidiosa) 		3 / 3 ALA A 191
VAL A 195
TRP A  20
 None
 0.81A 3l8lA-2x64A:
undetectable
3l8lB-2x64A:
undetectable		 3l8lA-2x64A:
9.09
3l8lB-2x64A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 2x64 GLUTATHIONE-S-TRANSF
ERASE
(Xylella
fastidiosa) 		3 / 3 TRP A  20
ALA A 197
VAL A 195
 None
 0.98A 3l8lA-2x64A:
undetectable
3l8lB-2x64A:
undetectable		 3l8lA-2x64A:
9.09
3l8lB-2x64A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2x64 GLUTATHIONE-S-TRANSF
ERASE
(Xylella
fastidiosa) 		4 / 7 LEU A 116
THR A 113
LEU A 109
MET A 105
 None
 0.97A 5fxtA-2x64A:
undetectable		 5fxtA-2x64A:
21.75