SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 2x66 PRNB
(Pseudomonas
fluorescens) 		3 / 3 VAL A 119
VAL A 117
TRP A 120
 None
 0.57A 1av2A-2x66A:
undetectable
1av2B-2x66A:
undetectable		 1av2A-2x66A:
5.63
1av2B-2x66A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 12 LEU A 161
PHE A 171
LEU A 178
VAL A 305
VAL A 354
 None
 1.30A 1hrkB-2x66A:
undetectable		 1hrkB-2x66A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 2x66 PRNB
(Pseudomonas
fluorescens) 		3 / 3 PRO A 198
ASP A 136
ASP A 203
 None
 0.77A 1sqfA-2x66A:
undetectable		 1sqfA-2x66A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 2x66 PRNB
(Pseudomonas
fluorescens) 		3 / 3 VAL A 119
VAL A 117
TRP A 120
 None
 0.49A 1w5uA-2x66A:
undetectable
1w5uB-2x66A:
undetectable		 1w5uA-2x66A:
5.63
1w5uB-2x66A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2x66 PRNB
(Pseudomonas
fluorescens) 		4 / 4 GLY A 295
SER A 175
VAL A 354
LEU A 166
 None
 1.18A 1yajB-2x66A:
undetectable		 1yajB-2x66A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 2x66 PRNB
(Pseudomonas
fluorescens) 		3 / 3 VAL A 117
TRP A 120
VAL A 119
 None
 0.56A 2izqC-2x66A:
undetectable
2izqD-2x66A:
undetectable		 2izqC-2x66A:
5.63
2izqD-2x66A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2x66 PRNB
(Pseudomonas
fluorescens) 		4 / 5 PRO A 198
ALA A 320
ASP A 136
ASP A 203
 None
HEM  A1359 (-3.5A)
None
None
 1.12A 2nyuB-2x66A:
undetectable		 2nyuB-2x66A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 12 LEU A 161
PHE A 171
LEU A 178
VAL A 305
VAL A 354
 None
 1.29A 2pnjB-2x66A:
undetectable		 2pnjB-2x66A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 11 LEU A 161
PHE A 171
LEU A 178
VAL A 305
VAL A 354
 None
 1.34A 2po5B-2x66A:
undetectable		 2po5B-2x66A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 11 LEU A 229
PHE A 309
LEU A 151
LEU A 115
VAL A 119
 HEM  A1359 (-4.5A)
HEM  A1359 (-4.7A)
None
None
None
 1.24A 2po5B-2x66A:
undetectable		 2po5B-2x66A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 12 LEU A 161
PHE A 171
LEU A 178
VAL A 305
VAL A 354
 None
 1.36A 2qd4B-2x66A:
undetectable		 2qd4B-2x66A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 9 LEU A 279
LEU A 299
ALA A 273
LEU A 236
PHE A 303
 None
 1.24A 2vcvD-2x66A:
3.7		 2vcvD-2x66A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 9 LEU A 279
LEU A 299
ALA A 273
LEU A 236
PHE A 303
 None
 1.25A 2vcvE-2x66A:
undetectable		 2vcvE-2x66A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 9 LEU A 279
LEU A 299
ALA A 273
LEU A 236
PHE A 303
 None
 1.28A 2vcvH-2x66A:
3.6		 2vcvH-2x66A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 9 LEU A 279
LEU A 299
ALA A 273
LEU A 236
PHE A 303
 None
 1.20A 2vcvI-2x66A:
3.4		 2vcvI-2x66A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 12 MET A 185
ALA A 311
ALA A 150
ALA A 154
THR A 158
 None
 1.30A 2x2nA-2x66A:
undetectable		 2x2nA-2x66A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1314_1
(CHOLINE-BINDING
PROTEIN F)		 2x66 PRNB
(Pseudomonas
fluorescens) 		4 / 5 ASP A   6
ARG A   7
TYR A 181
GLU A 177
 None
 1.37A 2x8oA-2x66A:
0.0		 2x8oA-2x66A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 12 LEU A 161
PHE A 171
LEU A 178
VAL A 305
VAL A 354
 None
 1.28A 3aqiB-2x66A:
undetectable		 3aqiB-2x66A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 11 LEU A 229
GLU A 233
LEU A 343
ARG A 310
LEU A 254
 HEM  A1359 (-4.5A)
None
HEM  A1359 (-4.6A)
HEM  A1359 (-4.0A)
None
 1.30A 3hm1B-2x66A:
undetectable		 3hm1B-2x66A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 12 PHE A  76
LEU A 205
GLY A 133
LEU A  31
PRO A  34
 None
 0.99A 3i5uA-2x66A:
undetectable		 3i5uA-2x66A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 12 ASP A 203
GLU A 204
PRO A 135
ILE A 196
THR A 132
 None
None
None
HEM  A1359 ( 4.8A)
None
 1.43A 3lpsA-2x66A:
undetectable		 3lpsA-2x66A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 7 ARG A 353
ALA A 350
ILE A 275
TRP A 237
GLY A 238
 None
 0.98A 3v4tH-2x66A:
undetectable		 3v4tH-2x66A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 12 LEU A 161
PHE A 171
LEU A 178
VAL A 305
VAL A 354
 None
 1.27A 3w1wA-2x66A:
undetectable		 3w1wA-2x66A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 12 LEU A 161
PHE A 171
LEU A 178
VAL A 305
VAL A 354
 None
 1.30A 3w1wB-2x66A:
undetectable		 3w1wB-2x66A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2x66 PRNB
(Pseudomonas
fluorescens) 		3 / 3 ARG A 353
TRP A 237
GLY A 238
 None
 0.84A 4e7cA-2x66A:
undetectable		 4e7cA-2x66A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2x66 PRNB
(Pseudomonas
fluorescens) 		4 / 5 ARG A 353
ILE A 275
TRP A 237
GLY A 238
 None
 0.98A 4e7cC-2x66A:
undetectable		 4e7cC-2x66A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 11 LEU A 161
PHE A 171
LEU A 178
VAL A 305
VAL A 354
 None
 1.39A 4mk4B-2x66A:
0.1		 4mk4B-2x66A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2x66 PRNB
(Pseudomonas
fluorescens) 		5 / 12 PHE A 162
ALA A 278
ALA A 298
GLY A 295
LEU A 296
 None
 1.10A 4oaeA-2x66A:
undetectable		 4oaeA-2x66A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 2x66 PRNB
(Pseudomonas
fluorescens) 		4 / 6 ARG A 283
ARG A 353
ASP A 280
VAL A 354
 None
 1.01A 4xqeA-2x66A:
undetectable		 4xqeA-2x66A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2x66 PRNB
(Pseudomonas
fluorescens) 		4 / 6 ARG A 283
ARG A 353
ASP A 280
VAL A 354
 None
 1.00A 4xqeB-2x66A:
undetectable		 4xqeB-2x66A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 2x66 PRNB
(Pseudomonas
fluorescens) 		4 / 8 ARG A 283
ARG A 353
ASP A 280
VAL A 354
 None
 1.01A 4xqgA-2x66A:
undetectable		 4xqgA-2x66A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2x66 PRNB
(Pseudomonas
fluorescens) 		4 / 8 ARG A 283
ARG A 353
ASP A 280
VAL A 354
 None
 1.02A 4xqgB-2x66A:
undetectable		 4xqgB-2x66A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2x66 PRNB
(Pseudomonas
fluorescens) 		4 / 5 LEU A  78
TYR A 219
LEU A  99
GLU A  96
 None
 1.32A 5weaA-2x66A:
undetectable		 5weaA-2x66A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2x66 PRNB
(Pseudomonas
fluorescens) 		4 / 6 PRO A 222
GLY A 223
LEU A 140
VAL A 117
 None
CYN  A1358 (-3.8A)
None
None
 0.83A 5x80A-2x66A:
0.8
5x80B-2x66A:
0.4		 5x80A-2x66A:
20.27
5x80B-2x66A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2x66 PRNB
(Pseudomonas
fluorescens) 		4 / 5 TYR A 181
VAL A 190
PHE A  11
GLY A   9
 None
 1.42A 6hd4A-2x66A:
undetectable		 6hd4A-2x66A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2x66 PRNB
(Pseudomonas
fluorescens) 		4 / 6 LEU A 108
HIS A  15
TYR A 261
GLU A 152
 None
 1.07A 6pahA-2x66A:
undetectable		 6pahA-2x66A:
24.49