SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x6k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		5 / 12 ALA A 695
PHE A 684
PHE A 654
PHE A 632
LEU A 672
 None
 1.08A 1dtlA-2x6kA:
undetectable		 1dtlA-2x6kA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		5 / 11 VAL A 796
LEU A 924
LEU A 921
LEU A 912
GLU A 906
 None
 1.36A 1mmtA-2x6kA:
undetectable		 1mmtA-2x6kA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		4 / 6 TYR A 794
TYR A 732
GLN A 705
ILE A 709
 None
X6K  A1951 ( 4.3A)
None
None
 1.44A 2pgzD-2x6kA:
undetectable
2pgzE-2x6kA:
undetectable		 2pgzD-2x6kA:
14.51
2pgzE-2x6kA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		5 / 12 LEU A 800
ASN A 907
LEU A 801
GLY A 802
MET A 839
 None
 1.33A 2q7lA-2x6kA:
undetectable		 2q7lA-2x6kA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		4 / 7 LEU A 879
ASN A 876
GLU A 363
TYR A 308
 None
 1.23A 2w8yA-2x6kA:
undetectable		 2w8yA-2x6kA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		5 / 12 LEU A 871
LEU A 729
LEU A 396
LEU A 881
TYR A 397
 None
 1.39A 3adsA-2x6kA:
undetectable		 3adsA-2x6kA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		4 / 8 LEU A 813
PHE A 766
THR A 786
ALA A 848
 None
 0.89A 3ax9B-2x6kA:
3.4		 3ax9B-2x6kA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		4 / 6 THR A 814
LYS A 818
PHE A 820
TYR A 746
 None
None
None
X6K  A1951 ( 4.6A)
 0.92A 3elzB-2x6kA:
undetectable		 3elzB-2x6kA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		5 / 12 THR A 798
LEU A 729
ILE A 788
MET A 849
LEU A 841
 None
 1.21A 3gwxA-2x6kA:
undetectable		 3gwxA-2x6kA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		4 / 7 TYR A 868
MET A 839
LEU A 841
LEU A 921
 None
 1.16A 3nk2X-2x6kA:
undetectable		 3nk2X-2x6kA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		5 / 10 THR A 670
PHE A 632
PHE A 684
VAL A 644
PHE A 649
 None
 1.45A 3u9fI-2x6kA:
undetectable		 3u9fI-2x6kA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		4 / 5 TYR A 397
LEU A 396
LEU A 719
ARG A 722
 None
 1.14A 4em2A-2x6kA:
0.6		 4em2A-2x6kA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		3 / 3 TYR A 826
ARG A 806
HIS A 807
 None
 1.12A 4fubA-2x6kA:
undetectable		 4fubA-2x6kA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		4 / 8 LEU A 808
PRO A 837
VAL A 803
GLY A 804
 None
 0.96A 4klrB-2x6kA:
undetectable		 4klrB-2x6kA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		4 / 8 LEU A 594
LEU A 587
VAL A 586
ILE A 538
 None
 0.81A 4oj4A-2x6kA:
undetectable		 4oj4A-2x6kA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		3 / 3 SER A 556
TYR A 552
ASP A 609
 None
 0.84A 4rp8C-2x6kA:
undetectable		 4rp8C-2x6kA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		6 / 12 PRO A 679
ILE A 696
TYR A 732
VAL A 747
THR A 751
ILE A 822
 None
None
X6K  A1951 ( 4.3A)
X6K  A1951 (-4.1A)
None
X6K  A1951 (-4.1A)
 0.56A 4xe0A-2x6kA:
28.5		 4xe0A-2x6kA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		3 / 3 GLU A 906
LYS A 902
ASN A 907
 None
 1.11A 4y1dA-2x6kA:
undetectable
4y1dD-2x6kA:
undetectable		 4y1dA-2x6kA:
13.90
4y1dD-2x6kA:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		5 / 12 TYR A 732
LEU A 801
LEU A 708
PHE A 824
MET A 712
 X6K  A1951 ( 4.3A)
None
None
None
None
 1.25A 4ze1A-2x6kA:
undetectable		 4ze1A-2x6kA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		5 / 10 PHE A 551
ALA A 541
LEU A 369
LEU A 405
PHE A 536
 None
 1.29A 4zmeB-2x6kA:
3.0		 4zmeB-2x6kA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		5 / 12 PHE A 860
CYH A 791
LEU A 811
MET A 845
LEU A 925
 None
 1.36A 5ji0D-2x6kA:
undetectable		 5ji0D-2x6kA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		4 / 8 LEU A 801
PHE A 882
MET A 712
ILE A 893
 None
 0.96A 5mzjA-2x6kA:
2.4		 5mzjA-2x6kA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		3 / 3 GLU A 570
HIS A 573
VAL A 565
 None
 0.89A 5trqB-2x6kA:
undetectable		 5trqB-2x6kA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		4 / 6 TYR A 576
LEU A 401
GLU A 408
LEU A 533
 None
 1.18A 5xooA-2x6kA:
3.7		 5xooA-2x6kA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		5 / 12 PHE A 860
CYH A 791
LEU A 811
MET A 845
LEU A 925
 None
 1.27A 5y2oA-2x6kA:
undetectable		 5y2oA-2x6kA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		5 / 12 PHE A 860
CYH A 791
LEU A 811
MET A 845
LEU A 925
 None
 1.28A 5ycpA-2x6kA:
undetectable		 5ycpA-2x6kA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		4 / 9 PHE A 743
HIS A 699
LEU A 710
ASP A 823
 None
None
None
X6K  A1951 (-3.5A)
 0.96A 6c2mD-2x6kA:
undetectable		 6c2mD-2x6kA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		3 / 3 GLU A 905
LEU A 908
ARG A 872
 None
 0.74A 6d8fA-2x6kA:
undetectable		 6d8fA-2x6kA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		4 / 5 GLN A 863
THR A 798
HIS A 821
LEU A 819
 None
 1.40A 6gbnA-2x6kA:
undetectable		 6gbnA-2x6kA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		4 / 5 GLN A 863
THR A 798
HIS A 821
LEU A 819
 None
 1.37A 6gbnD-2x6kA:
undetectable		 6gbnD-2x6kA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		4 / 4 ASP A 706
ILE A 713
PRO A 731
LEU A 710
 X6K  A1951 (-3.4A)
None
None
None
 1.44A 6mkeB-2x6kA:
undetectable		 6mkeB-2x6kA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F
(Drosophila
melanogaster) 		4 / 4 ASP A 706
ILE A 713
PRO A 731
LEU A 710
 X6K  A1951 (-3.4A)
None
None
None
 1.40A 6mkeA-2x6kA:
undetectable		 6mkeA-2x6kA:
8.30