SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2REZ_A_ACTA156_0 (MULTIFUNCTIONAL CYCLASE-DEHYDRATASE- 3-O-METHYL TRANSFERASE TCMN)	2x6n	INTEGRASE (Simian foamy virus)	4 / 7	THR A 174 TRP A 198 MET A 127 LEU A 143	None	1.33A	2rezA-2x6nA: undetectable	2rezA-2x6nA: 21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3L2V_A_RLTA397_1 (INTEGRASE)	2x6n	INTEGRASE (Simian foamy virus)	4 / 7	ASP A 128 ASP A 185 GLN A 186 GLN A 215	MN A1197 (-2.7A) MN A1197 (-2.6A) None None	1.13A	3l2vA-2x6nA: 19.9	3l2vA-2x6nA: 97.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WW7_A_ACTA305_0 (EKC/KEOPS COMPLEX SUBUNIT BUD32)	2x6n	INTEGRASE (Simian foamy virus)	4 / 6	LEU A 231 LEU A 234 ILE A 298 MET A 253	None	0.95A	4ww7A-2x6nA: undetectable	4ww7A-2x6nA: 21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZE1_A_X2NA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	2x6n	INTEGRASE (Simian foamy virus)	5 / 12	GLY A 151 LEU A 143 PHE A 190 GLY A 187 MET A 127	None	1.31A	4ze1A-2x6nA: undetectable	4ze1A-2x6nA: 19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O96_B_SAMB501_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E)	2x6n	INTEGRASE (Simian foamy virus)	5 / 9	LEU A 295 ILE A 298 LEU A 284 LEU A 251 ALA A 252	None	0.88A	5o96A-2x6nA: undetectable 5o96B-2x6nA: undetectable	5o96A-2x6nA: 19.59 5o96B-2x6nA: 19.59

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2REZ_A_ACTA156_0","MULTIFUNCTIONAL CYCLASE-DEHYDRATASE-3-O-METHYL TRANSFERASE TCMN","2x6n","INTEGRASE","Simian foamy virus",4,"THR A 174;TRP A 198;MET A 127;LEU A 143","None","1.33A","2rezA-2x6nA:undetectable","2rezA-2x6nA:21.40"],["3L2V_A_RLTA397_1","INTEGRASE","2x6n","INTEGRASE","Simian foamy virus",4,"ASP A 128;ASP A 185;GLN A 186;GLN A 215"," MN A1197 (-2.7A); MN A1197 (-2.6A);None;None","1.13A","3l2vA-2x6nA:19.9","3l2vA-2x6nA:97.00"],["4WW7_A_ACTA305_0","EKC\/KEOPS COMPLEX SUBUNIT BUD32","2x6n","INTEGRASE","Simian foamy virus",4,"LEU A 231;LEU A 234;ILE A 298;MET A 253","None","0.95A","4ww7A-2x6nA:undetectable","4ww7A-2x6nA:21.86"],["4ZE1_A_X2NA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","2x6n","INTEGRASE","Simian foamy virus",5,"GLY A 151;LEU A 143;PHE A 190;GLY A 187;MET A 127","None","1.31A","4ze1A-2x6nA:undetectable","4ze1A-2x6nA:19.60"],["5O96_B_SAMB501_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E","2x6n","INTEGRASE","Simian foamy virus",5,"LEU A 295;ILE A 298;LEU A 284;LEU A 251;ALA A 252","None","0.88A","5o96A-2x6nA:undetectable;5o96B-2x6nA:undetectable","5o96A-2x6nA:19.59;5o96B-2x6nA:19.59"]]