SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		5 / 11 ALA A  22
THR A  15
VAL A  56
ALA A  59
ALA A  72
 None
 0.91A 1jinA-2x75A:
0.6		 1jinA-2x75A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		5 / 12 SER A 103
GLU A 176
ARG A 172
ASP A 116
ILE A  13
 None
 1.11A 1s14A-2x75A:
undetectable		 1s14A-2x75A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		5 / 12 SER A 103
GLU A 176
ARG A 172
ASP A 116
ILE A  13
 None
 1.17A 1s14B-2x75A:
undetectable		 1s14B-2x75A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		3 / 3 TYR A  20
ARG A  67
GLN A  64
 None
 0.95A 1tw4A-2x75A:
undetectable		 1tw4A-2x75A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		5 / 12 GLY A 286
ALA A 227
ILE A 288
GLY A 279
ALA A 230
 None
 0.96A 1utdL-2x75A:
undetectable
1utdM-2x75A:
undetectable		 1utdL-2x75A:
10.67
1utdM-2x75A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		5 / 12 THR A  93
VAL A  70
ASP A  69
SER A 306
HIS A 305
 None
 1.13A 1xvaA-2x75A:
undetectable		 1xvaA-2x75A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		4 / 7 ALA A 237
ARG A 241
TYR A   5
TYR A 322
 None
None
AMP  A1433 (-4.5A)
None
 1.04A 2ajvH-2x75A:
undetectable
2ajvL-2x75A:
undetectable		 2ajvH-2x75A:
18.36
2ajvL-2x75A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		4 / 8 LEU A 320
ILE A 113
GLU A 176
ILE A 223
 None
 0.93A 2azxA-2x75A:
undetectable		 2azxA-2x75A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		5 / 11 LEU A 320
VAL A 316
SER A 232
ILE A 284
ALA A 220
 None
 1.15A 2zbzA-2x75A:
undetectable		 2zbzA-2x75A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		5 / 12 GLY A 178
GLY A 205
SER A 210
PHE A 104
THR A 100
 None
 1.26A 3dh0A-2x75A:
undetectable		 3dh0A-2x75A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		5 / 12 SER A 103
GLU A 176
ARG A 172
ASP A 116
ILE A  13
 None
 1.17A 3lpsA-2x75A:
undetectable		 3lpsA-2x75A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		4 / 8 ALA A 371
LEU A 358
ASP A 396
SER A 398
 None
 0.89A 3qj7A-2x75A:
undetectable
3qj7D-2x75A:
undetectable		 3qj7A-2x75A:
20.43
3qj7D-2x75A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		4 / 8 GLU A  27
GLU A 195
GLY A 182
SER A 181
 None
 0.94A 4f93B-2x75A:
undetectable		 4f93B-2x75A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		5 / 12 SER A 103
GLU A 176
ARG A 172
ASP A 116
ILE A  13
 None
 1.12A 4uroA-2x75A:
undetectable		 4uroA-2x75A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		5 / 12 SER A 103
GLU A 176
ARG A 172
ASP A 116
ILE A  13
 None
 1.07A 4uroB-2x75A:
undetectable		 4uroB-2x75A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		5 / 12 SER A 103
GLU A 176
ARG A 172
ASP A 116
ILE A  13
 None
 1.14A 4uroD-2x75A:
undetectable		 4uroD-2x75A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		3 / 3 THR A 385
THR A 387
PHE A 389
 None
 0.92A 5cxvA-2x75A:
1.2		 5cxvA-2x75A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		3 / 3 LYS A 415
ASP A 413
ARG A 342
 None
 0.96A 5jwaA-2x75A:
undetectable
5jwaH-2x75A:
undetectable		 5jwaA-2x75A:
20.64
5jwaH-2x75A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2x75 ADENYLOSUCCINATE
LYASE
(Staphylococcus
aureus) 		3 / 3 LEU A 214
ASN A 110
LEU A 313
 CL  A1435 ( 4.6A)
None
None
 0.73A 6exiD-2x75A:
undetectable		 6exiD-2x75A:
11.37