SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		4 / 5 SER A 163
SER A 161
VAL A  94
PHE A 127
 GDP  A 188 (-4.2A)
None
None
None
 1.48A 1oipA-2x77A:
undetectable		 1oipA-2x77A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		3 / 3 ASP A 135
ASP A 132
ASP A  99
 None
GDP  A 188 (-2.6A)
None
 0.65A 2igtB-2x77A:
undetectable		 2igtB-2x77A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		4 / 6 LEU A  40
GLY A  43
LEU A   8
SER A   7
 None
 0.73A 3aiaA-2x77A:
undetectable		 3aiaA-2x77A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		4 / 5 LEU A  15
LYS A   9
GLN A  10
LEU A  12
 None
 1.09A 3h5gA-2x77A:
undetectable
3h5gB-2x77A:
undetectable		 3h5gA-2x77A:
8.99
3h5gB-2x77A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		4 / 8 TYR A  93
LEU A  28
LEU A  71
GLY A  72
 None
 0.81A 4c9nA-2x77A:
undetectable		 4c9nA-2x77A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		5 / 10 LEU A  24
GLU A  67
SER A 122
ILE A  21
THR A  58
 None
 1.11A 4g8zX-2x77A:
undetectable		 4g8zX-2x77A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		5 / 12 LEU A  37
SER A 163
MET A 173
PHE A 127
VAL A  94
 None
GDP  A 188 (-4.2A)
None
None
None
 1.21A 4ib4A-2x77A:
undetectable		 4ib4A-2x77A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		4 / 5 LYS A 164
ARG A  39
LEU A 169
ASP A 167
 None
 1.23A 4ifxA-2x77A:
undetectable		 4ifxA-2x77A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		4 / 5 LYS A 164
ARG A  39
LEU A 169
ASP A 167
 None
 1.22A 4ig1A-2x77A:
undetectable		 4ig1A-2x77A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		5 / 9 VAL A 159
ILE A 158
TRP A 156
LEU A 114
LEU A 110
 None
 1.21A 4l1xB-2x77A:
0.8		 4l1xB-2x77A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		5 / 12 ILE A  21
ALA A  90
ILE A  92
LEU A  40
ILE A  64
 None
 1.07A 4m2xG-2x77A:
undetectable		 4m2xG-2x77A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		5 / 12 LEU A  37
SER A 163
MET A 173
PHE A 127
VAL A  94
 None
GDP  A 188 (-4.2A)
None
None
None
 1.26A 4nc3A-2x77A:
undetectable		 4nc3A-2x77A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		4 / 5 LYS A 164
ARG A  39
LEU A 169
ASP A 167
 None
 1.38A 4xdtA-2x77A:
undetectable		 4xdtA-2x77A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		6 / 11 LEU A   8
LEU A 169
LEU A 123
LEU A  15
LEU A  12
ILE A  64
 None
 1.13A 4zowA-2x77A:
undetectable		 4zowA-2x77A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		6 / 11 LEU A  40
LEU A 123
LEU A  15
LEU A  12
ILE A  64
LEU A 180
 None
 1.35A 4zowA-2x77A:
undetectable		 4zowA-2x77A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		4 / 5 LEU A  26
ARG A  78
LEU A 119
TRP A  69
 None
 1.15A 5m10A-2x77A:
2.4		 5m10A-2x77A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 2x77 ADP-RIBOSYLATION
FACTOR
(Leishmania
major) 		5 / 9 LEU A  12
VAL A 170
LEU A   8
ILE A  92
LEU A 180
 None
 1.36A 5og9A-2x77A:
undetectable		 5og9A-2x77A:
17.87