SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x7i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		5 / 11 PHE A 231
ILE A 287
ALA A 260
LEU A 277
ALA A 228
 None
 1.35A 1jb0B-2x7iA:
undetectable		 1jb0B-2x7iA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		4 / 5 LEU A  15
PRO A 154
VAL A  30
ILE A  28
 None
 0.89A 2aoiB-2x7iA:
undetectable		 2aoiB-2x7iA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		5 / 9 ALA A 278
GLY A 263
LEU A 275
VAL A 291
ILE A 287
 None
 1.16A 3em4B-2x7iA:
undetectable		 3em4B-2x7iA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A  15
ALA A 215
PRO A 154
VAL A  30
ILE A  28
 None
 0.90A 3lzuB-2x7iA:
undetectable		 3lzuB-2x7iA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		5 / 10 LEU A  15
ALA A 215
PRO A 154
VAL A  30
ILE A  28
 None
 0.94A 3oxwD-2x7iA:
undetectable		 3oxwD-2x7iA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		5 / 11 PHE A 231
ILE A 287
ALA A 260
LEU A 277
ALA A 228
 None
 1.34A 3pcqB-2x7iA:
undetectable		 3pcqB-2x7iA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		4 / 7 VAL A  30
MET A 174
LEU A 170
ILE A 219
 None
 1.01A 3rfmA-2x7iA:
undetectable		 3rfmA-2x7iA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		4 / 5 THR A 146
GLY A 143
PRO A 141
ASN A 131
 None
 1.24A 3u8qA-2x7iA:
undetectable		 3u8qA-2x7iA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		4 / 8 PHE A 231
HIS A 235
GLY A 263
GLY A  17
 None
 0.80A 3v3nB-2x7iA:
undetectable		 3v3nB-2x7iA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		4 / 8 PHE A 231
HIS A 235
GLY A 263
GLY A  17
 None
 0.79A 3v3nC-2x7iA:
undetectable		 3v3nC-2x7iA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		5 / 12 GLY A  98
GLY A 271
SER A 273
GLY A  35
ASP A 178
 CIT  A1307 (-3.3A)
CL  A1308 ( 4.9A)
None
None
None
 1.19A 4blvB-2x7iA:
undetectable		 4blvB-2x7iA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A  15
ALA A 215
PRO A 154
VAL A  30
ILE A  28
 None
 0.80A 4dqfA-2x7iA:
undetectable		 4dqfA-2x7iA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		4 / 7 ILE A 230
LEU A 277
LEU A  15
ILE A 219
 None
 0.82A 4rmjA-2x7iA:
undetectable		 4rmjA-2x7iA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		5 / 12 GLY A 269
GLY A 271
THR A 266
LEU A 238
HIS A 235
 None
CL  A1308 ( 4.9A)
CL  A1308 (-4.2A)
None
None
 1.10A 5kocB-2x7iA:
undetectable		 5kocB-2x7iA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		5 / 9 ILE A  16
VAL A  30
MET A 174
LEU A 170
ILE A 219
 None
 1.20A 5mzpA-2x7iA:
undetectable		 5mzpA-2x7iA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		4 / 5 TYR A   6
SER A   9
ALA A 108
GLN A  90
 None
 1.32A 5n4iA-2x7iA:
undetectable		 5n4iA-2x7iA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		5 / 12 PHE A 231
ILE A 287
ALA A 260
LEU A 277
ALA A 228
 None
 1.32A 5oy02-2x7iA:
undetectable		 5oy02-2x7iA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		5 / 10 PHE A 231
ILE A 287
ALA A 260
LEU A 277
ALA A 228
 None
 1.30A 5oy0b-2x7iA:
undetectable		 5oy0b-2x7iA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		3 / 3 TRP A 300
ILE A 177
ASP A 178
 None
 0.88A 6i0y7-2x7iA:
undetectable		 6i0y7-2x7iA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2x7i MEVALONATE KINASE
(Staphylococcus
aureus) 		5 / 9 ILE A 208
ALA A 268
GLY A 269
LEU A 265
GLY A  98
 None
None
None
None
CIT  A1307 (-3.3A)
 1.02A 6nm4B-2x7iA:
undetectable		 6nm4B-2x7iA:
21.80