SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 2x7l FAB HEAVY CHAIN
(unidentified) 		5 / 12 ARG A  67
PRO A  41
LEU A  20
LEU A  81
ASP A  88
 None
 1.34A 1e7wA-2x7lA:
undetectable		 1e7wA-2x7lA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 2x7l FAB LIGHT CHAIN
(unidentified) 		5 / 12 PHE B  62
GLY B  64
SER B  65
THR B  72
ASN B  53
 None
 1.22A 1g60A-2x7lB:
undetectable		 1g60A-2x7lB:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 2x7l FAB HEAVY CHAIN
FAB LIGHT CHAIN
(unidentified) 		7 / 12 TYR B  36
PHE B 101
TRP A  33
ASN A  35
VAL A  37
ALA A  95
TRP A 107
 None
 0.69A 1h8sA-2x7lB:
20.2		 1h8sA-2x7lB:
37.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQE_B_DXCB1079_0
(PROTEIN PRGI, CELL
INVASION PROTEIN
SIPD)		 2x7l FAB LIGHT CHAIN
(unidentified) 		5 / 11 THR B  99
LEU B   2
TYR B  97
TYR B  92
SER B  28
 None
 1.33A 3zqeA-2x7lB:
0.0
3zqeB-2x7lB:
0.0		 3zqeA-2x7lB:
25.16
3zqeB-2x7lB:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2x7l FAB HEAVY CHAIN
(unidentified) 		5 / 10 PHE A 126
GLY A 122
THR A 209
VAL A 202
VAL A 211
 None
 1.20A 4jx1B-2x7lA:
undetectable		 4jx1B-2x7lA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2x7l FAB HEAVY CHAIN
FAB LIGHT CHAIN
(unidentified;
unidentified) 		5 / 12 ILE B  48
GLN B   6
TYR B  86
GLN A  39
LEU A  45
 None
 1.50A 4qztA-2x7lB:
undetectable		 4qztA-2x7lB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2x7l FAB HEAVY CHAIN
(unidentified) 		4 / 7 ALA A  90
THR A  89
VAL A 113
GLU A  87
 None
 0.82A 5ecoD-2x7lA:
undetectable		 5ecoD-2x7lA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 2x7l FAB HEAVY CHAIN
(unidentified) 		4 / 6 THR A  21
LEU A  20
THR A  73
LEU A   4
 None
 1.22A 6mvxA-2x7lA:
undetectable
6mvxB-2x7lA:
undetectable
6mvxC-2x7lA:
undetectable		 6mvxA-2x7lA:
19.58
6mvxB-2x7lA:
19.58
6mvxC-2x7lA:
19.58