SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x7q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 6 ASN A  52
ILE A  46
ASN A  72
ASN A  74
 CA  A1308 (-3.3A)
None
None
None
 1.25A 1h7xA-2x7qA:
undetectable		 1h7xA-2x7qA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 6 ASN A  52
ILE A  46
ASN A  72
ASN A  74
 CA  A1308 (-3.3A)
None
None
None
 1.24A 1h7xB-2x7qA:
undetectable		 1h7xB-2x7qA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 6 ASN A  52
ILE A  46
ASN A  72
ASN A  74
 CA  A1308 (-3.3A)
None
None
None
 1.24A 1h7xC-2x7qA:
undetectable		 1h7xC-2x7qA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 6 ASN A  52
ILE A  46
ASN A  72
ASN A  74
 CA  A1308 (-3.3A)
None
None
None
 1.24A 1h7xD-2x7qA:
undetectable		 1h7xD-2x7qA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 8 LEU A 124
VAL A 130
GLY A 129
LEU A 105
 None
 0.82A 1jlbA-2x7qA:
undetectable		 1jlbA-2x7qA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 8 LEU A 124
VAL A 130
GLY A 129
LEU A 105
 None
 0.92A 1s1xA-2x7qA:
undetectable		 1s1xA-2x7qA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 8 TYR A  81
THR A  15
TRP A 190
LEU A 235
 None
 1.32A 1uw6A-2x7qA:
undetectable
1uw6B-2x7qA:
undetectable		 1uw6A-2x7qA:
22.74
1uw6B-2x7qA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 8 TYR A  81
THR A  15
TRP A 190
LEU A 235
 None
 1.31A 1uw6D-2x7qA:
undetectable
1uw6E-2x7qA:
undetectable		 1uw6D-2x7qA:
22.74
1uw6E-2x7qA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 8 TYR A  81
THR A  15
TRP A 190
LEU A 235
 None
 1.30A 1uw6G-2x7qA:
undetectable
1uw6H-2x7qA:
undetectable		 1uw6G-2x7qA:
22.74
1uw6H-2x7qA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 8 TYR A  81
THR A  15
TRP A 190
LEU A 235
 None
 1.30A 1uw6P-2x7qA:
undetectable
1uw6Q-2x7qA:
undetectable		 1uw6P-2x7qA:
22.74
1uw6Q-2x7qA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 8 TRP A 190
LEU A 235
TYR A  81
THR A  15
 None
 1.32A 1uw6P-2x7qA:
undetectable
1uw6T-2x7qA:
undetectable		 1uw6P-2x7qA:
22.74
1uw6T-2x7qA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		3 / 3 VAL A  82
VAL A 192
TRP A 190
 None
 0.82A 1w5uA-2x7qA:
undetectable
1w5uB-2x7qA:
undetectable		 1w5uA-2x7qA:
4.97
1w5uB-2x7qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 7 ILE A  46
ASN A  72
ILE A  68
ASP A  67
 None
 0.70A 1yc2E-2x7qA:
undetectable		 1yc2E-2x7qA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 5 ILE A  46
ASN A  72
ILE A  68
ASP A  67
 None
 0.76A 2h4jA-2x7qA:
undetectable		 2h4jA-2x7qA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		3 / 3 VAL A 192
TRP A 190
VAL A  82
 None
 0.87A 2izqC-2x7qA:
undetectable
2izqD-2x7qA:
undetectable		 2izqC-2x7qA:
4.97
2izqD-2x7qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 4 ARG A  44
GLY A  43
GLU A  40
SER A 195
 None
 1.23A 2xctS-2x7qA:
undetectable
2xctU-2x7qA:
undetectable		 2xctS-2x7qA:
18.04
2xctU-2x7qA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 8 ILE A 231
TRP A 245
PHE A  13
TYR A 237
 None
 1.15A 3ccfB-2x7qA:
undetectable		 3ccfB-2x7qA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 6 ILE A 231
THR A 248
PHE A 251
TYR A 220
 None
GOL  A1307 (-3.8A)
None
None
 1.32A 3elzB-2x7qA:
undetectable		 3elzB-2x7qA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		5 / 10 ASP A 225
ALA A 227
THR A 185
ILE A  58
ILE A 255
 None
 1.15A 3prsA-2x7qA:
undetectable		 3prsA-2x7qA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		5 / 10 PHE A  64
LEU A  17
VAL A 213
PHE A 209
VAL A   6
 None
 1.46A 3u9fR-2x7qA:
undetectable		 3u9fR-2x7qA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 5 ASP A 159
SER A 158
GLY A 157
ASP A  98
 None
 1.36A 3w9tB-2x7qA:
undetectable		 3w9tB-2x7qA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		5 / 11 TYR A  26
GLN A 218
TYR A  81
ILE A  58
PHE A 209
 None
 1.23A 4driA-2x7qA:
undetectable		 4driA-2x7qA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 7 THR A 269
LEU A 260
VAL A 191
THR A  80
 None
 0.84A 5e4dA-2x7qA:
undetectable
5e4dB-2x7qA:
undetectable		 5e4dA-2x7qA:
23.82
5e4dB-2x7qA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		5 / 11 PHE A 251
ILE A 255
ASN A 214
VAL A  82
PRO A  16
 None
 1.29A 5hjiA-2x7qA:
undetectable		 5hjiA-2x7qA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 6 ILE A  65
ILE A  56
LEU A  49
PHE A  35
 None
 0.97A 5vkqA-2x7qA:
undetectable
5vkqB-2x7qA:
undetectable		 5vkqA-2x7qA:
10.78
5vkqB-2x7qA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 6 ILE A  65
ILE A  56
LEU A  49
PHE A  35
 None
 0.97A 5vkqB-2x7qA:
undetectable
5vkqC-2x7qA:
undetectable		 5vkqB-2x7qA:
10.78
5vkqC-2x7qA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 6 ILE A  65
ILE A  56
LEU A  49
PHE A  35
 None
 0.94A 5vkqC-2x7qA:
undetectable
5vkqD-2x7qA:
undetectable		 5vkqC-2x7qA:
10.78
5vkqD-2x7qA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME
(Candida
albicans) 		4 / 6 PHE A  35
ILE A  65
ILE A  56
LEU A  49
 None
 0.96A 5vkqA-2x7qA:
undetectable
5vkqD-2x7qA:
undetectable		 5vkqA-2x7qA:
10.78
5vkqD-2x7qA:
10.78