SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x7x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 160
ARG A 172
PHE A 176
GLY A 140
 None
FRU  A1335 (-2.8A)
None
None
 0.87A 1fapB-2x7xA:
undetectable		 1fapB-2x7xA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 201
GLU A 204
LEU A 160
ILE A 247
GLY A 246
 None
 0.85A 1qknA-2x7xA:
undetectable		 1qknA-2x7xA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 PRO A 227
GLY A 256
ASN A 255
GLY A 254
 None
 0.81A 1zlqA-2x7xA:
1.3		 1zlqA-2x7xA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ALA A 233
ILE A 215
VAL A 218
PHE A 244
 None
 0.94A 2cizA-2x7xA:
undetectable		 2cizA-2x7xA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A 247
GLY A 246
LEU A 265
LEU A 259
 None
 0.93A 2vctC-2x7xA:
2.1		 2vctC-2x7xA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 201
GLU A 204
LEU A 160
ILE A 247
GLY A 246
 None
 0.91A 2yjaB-2x7xA:
undetectable		 2yjaB-2x7xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 201
GLU A 204
LEU A 160
ILE A 247
GLY A 246
 None
 0.76A 3q95A-2x7xA:
undetectable		 3q95A-2x7xA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 201
GLU A 204
LEU A 160
ILE A 247
GLY A 246
 None
 0.80A 3q95B-2x7xA:
undetectable		 3q95B-2x7xA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 PRO A 272
THR A 273
LEU A 250
 None
 0.60A 3ttrA-2x7xA:
undetectable		 3ttrA-2x7xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 120
ARG A 121
ASP A 248
 FRU  A1335 (-2.5A)
FRU  A1335 (-4.1A)
FRU  A1335 (-2.8A)
 0.83A 4fzvA-2x7xA:
undetectable		 4fzvA-2x7xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 ILE A 186
LEU A 151
LYS A 154
ASN A 156
 None
 0.97A 4g19A-2x7xA:
undetectable		 4g19A-2x7xA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 274
GLN A  39
GLN A 280
ILE A  53
 None
 1.03A 4iilA-2x7xA:
18.8		 4iilA-2x7xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 THR A 167
PRO A 168
ASN A 136
TYR A 271
 None
FRU  A1335 (-4.4A)
None
FRU  A1335 (-4.2A)
 1.38A 4mf6A-2x7xA:
undetectable		 4mf6A-2x7xA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 ASP A 266
VAL A 143
TYR A 146
SER A 150
SER A 149
 K  A1336 ( 4.2A)
None
None
None
None
 0.86A 4mmaA-2x7xA:
undetectable		 4mmaA-2x7xA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 ALA A 201
GLU A 204
LEU A 160
ILE A 247
GLY A 246
 None
 0.89A 4pxmB-2x7xA:
undetectable		 4pxmB-2x7xA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 ALA A 201
GLU A 204
LEU A 160
ILE A 247
GLY A 246
 None
 0.96A 5dxbB-2x7xA:
undetectable		 5dxbB-2x7xA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 201
GLU A 204
LEU A 160
ILE A 247
GLY A 246
 None
 0.97A 5gtrA-2x7xA:
undetectable		 5gtrA-2x7xA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 114
GLY A 113
ALA A 109
LEU A  92
VAL A  81
 None
 1.34A 5hw4B-2x7xA:
2.2		 5hw4B-2x7xA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		6 / 12 VAL A 143
ILE A 147
ALA A 148
VAL A 245
GLY A 246
ILE A 247
 None
 1.17A 5j2tC-2x7xA:
undetectable		 5j2tC-2x7xA:
22.73