SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		3 / 3 ASP A 710
PHE A 667
ASN A 703
 None
 0.83A 1sg9B-2x8aA:
undetectable		 1sg9B-2x8aA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		5 / 11 LEU A 793
LEU A 796
ALA A 800
PHE A 828
LEU A 770
 None
 1.02A 2qjuA-2x8aA:
undetectable		 2qjuA-2x8aA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		5 / 10 PHE A 828
SER A 801
ALA A 795
LEU A 796
ALA A 831
 None
 1.48A 2wscB-2x8aA:
undetectable		 2wscB-2x8aA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		5 / 10 PHE A 828
SER A 801
ALA A 795
LEU A 796
ALA A 831
 None
 1.48A 2wseB-2x8aA:
undetectable		 2wseB-2x8aA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		5 / 9 PHE A 828
SER A 801
ALA A 795
LEU A 796
ALA A 831
 None
 1.44A 2wsfB-2x8aA:
undetectable		 2wsfB-2x8aA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		4 / 8 GLY A 584
ALA A 585
ASP A 588
PRO A 623
 None
 0.65A 3el0A-2x8aA:
undetectable		 3el0A-2x8aA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		4 / 8 ILE A 779
PHE A 832
VAL A 823
VAL A 774
 None
 0.78A 3me6B-2x8aA:
undetectable		 3me6B-2x8aA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		3 / 3 GLY A 625
GLY A 627
THR A 629
 PO4  A1840 (-3.5A)
PO4  A1840 (-3.4A)
PO4  A1840 (-3.9A)
 0.44A 3si7B-2x8aA:
5.0		 3si7B-2x8aA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		5 / 12 PHE A 679
ILE A 730
LEU A 705
VAL A 663
ILE A 720
 None
 1.19A 3sp9A-2x8aA:
undetectable		 3sp9A-2x8aA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		4 / 8 GLY A 584
ALA A 585
ASP A 588
PRO A 623
 None
 0.66A 4eyrB-2x8aA:
undetectable		 4eyrB-2x8aA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		4 / 7 ALA A 780
PRO A 751
LEU A 793
LEU A 758
 None
 0.89A 4iomA-2x8aA:
2.2		 4iomA-2x8aA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		4 / 8 ALA A 780
PRO A 751
LEU A 793
LEU A 758
 None
 0.90A 4jjkA-2x8aA:
2.4		 4jjkA-2x8aA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		3 / 3 ASP A 588
GLY A 584
ASP A 753
 None
 0.70A 4xdtA-2x8aA:
undetectable		 4xdtA-2x8aA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		3 / 3 LYS A 821
ASP A 771
ILE A 802
 None
 0.81A 5kc4E-2x8aA:
undetectable		 5kc4E-2x8aA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		5 / 11 LEU A 705
GLY A 711
PHE A 680
ILE A 720
ILE A 678
 None
 1.08A 6ebzA-2x8aA:
undetectable		 6ebzA-2x8aA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens) 		5 / 11 LEU A 705
GLY A 711
PHE A 680
ILE A 720
ILE A 678
 None
 1.08A 6ebzB-2x8aA:
undetectable		 6ebzB-2x8aA:
13.21