SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2x8p CHOLINE-BINDING
PROTEIN F
(Streptococcus
pneumoniae) 		4 / 7 GLY A 270
THR A 253
ASP A 271
ASN A 266
 None
 1.01A 2g70A-2x8pA:
undetectable		 2g70A-2x8pA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2x8p CHOLINE-BINDING
PROTEIN F
(Streptococcus
pneumoniae) 		4 / 7 GLY A 270
THR A 253
ASP A 271
ASN A 266
 None
 1.03A 2g70B-2x8pA:
undetectable		 2g70B-2x8pA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2x8p CHOLINE-BINDING
PROTEIN F
(Streptococcus
pneumoniae) 		4 / 6 TYR A  77
GLY A  79
TYR A 109
ASP A  81
 None
 1.27A 2g72A-2x8pA:
undetectable		 2g72A-2x8pA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2x8p CHOLINE-BINDING
PROTEIN F
(Streptococcus
pneumoniae) 		4 / 5 GLU A 158
PRO A 155
ILE A 156
GLY A 157
 None
None
GOL  A1316 (-4.4A)
None
 1.18A 2qeuA-2x8pA:
undetectable
2qeuC-2x8pA:
undetectable		 2qeuA-2x8pA:
19.33
2qeuC-2x8pA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8O_A_OINA1314_1
(CHOLINE-BINDING
PROTEIN F)		 2x8p CHOLINE-BINDING
PROTEIN F
(Streptococcus
pneumoniae) 		5 / 5 LYS A  10
ASP A  11
ARG A  13
TYR A  15
GLU A  41
 None
 0.31A 2x8oA-2x8pA:
37.2		 2x8oA-2x8pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8O_A_OINA1317_1
(CHOLINE-BINDING
PROTEIN F)		 2x8p CHOLINE-BINDING
PROTEIN F
(Streptococcus
pneumoniae) 		4 / 4 TRP A 130
TRP A 137
TYR A 182
MET A 190
 CHT  A1321 (-4.0A)
CHT  A1321 (-3.9A)
None
CHT  A1321 (-3.5A)
 0.22A 2x8oA-2x8pA:
37.2		 2x8oA-2x8pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8O_A_OINA1317_1
(CHOLINE-BINDING
PROTEIN F)		 2x8p CHOLINE-BINDING
PROTEIN F
(Streptococcus
pneumoniae) 		4 / 4 TRP A 163
TRP A 181
TYR A 202
MET A 210
 OIN  A1315 (-3.5A)
OIN  A1315 (-3.5A)
None
OIN  A1315 ( 4.4A)
 0.42A 2x8oA-2x8pA:
37.2		 2x8oA-2x8pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8O_A_OINA1317_1
(CHOLINE-BINDING
PROTEIN F)		 2x8p CHOLINE-BINDING
PROTEIN F
(Streptococcus
pneumoniae) 		4 / 4 TRP A 194
TRP A 201
TYR A 222
MET A 231
 OIN  A1313 (-3.6A)
OIN  A1313 (-3.6A)
OIN  A1313 ( 4.8A)
OIN  A1313 ( 4.9A)
 0.22A 2x8oA-2x8pA:
37.2		 2x8oA-2x8pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8O_A_OINA1317_1
(CHOLINE-BINDING
PROTEIN F)		 2x8p CHOLINE-BINDING
PROTEIN F
(Streptococcus
pneumoniae) 		4 / 4 TRP A 214
TRP A 221
TYR A 243
MET A 251
 CHT  A1320 (-3.8A)
CHT  A1320 (-3.6A)
None
CHT  A1320 ( 4.6A)
 0.18A 2x8oA-2x8pA:
37.2		 2x8oA-2x8pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8O_A_OINA1317_1
(CHOLINE-BINDING
PROTEIN F)		 2x8p CHOLINE-BINDING
PROTEIN F
(Streptococcus
pneumoniae) 		4 / 4 TRP A 235
TRP A 242
TYR A 263
MET A 272
 CHT  A1319 (-3.6A)
CHT  A1319 (-3.9A)
None
CHT  A1319 ( 4.5A)
 0.26A 2x8oA-2x8pA:
37.2		 2x8oA-2x8pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2x8p CHOLINE-BINDING
PROTEIN F
(Streptococcus
pneumoniae) 		4 / 8 PHE A 146
GLY A 144
LEU A 143
ILE A 156
 None
None
GOL  A1316 (-4.6A)
GOL  A1316 (-4.4A)
 0.84A 4em2A-2x8pA:
undetectable		 4em2A-2x8pA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2x8p CHOLINE-BINDING
PROTEIN F
(Streptococcus
pneumoniae) 		3 / 3 ASN A 122
PHE A 120
TYR A  76
 None
 0.64A 4u15A-2x8pA:
undetectable		 4u15A-2x8pA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2x8p CHOLINE-BINDING
PROTEIN F
(Streptococcus
pneumoniae) 		5 / 10 GLY A 249
GLY A 234
LEU A 245
LEU A 238
TYR A 223
 None
 1.32A 5hwkA-2x8pA:
undetectable		 5hwkA-2x8pA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2x8p CHOLINE-BINDING
PROTEIN F
(Streptococcus
pneumoniae) 		5 / 10 GLY A 249
GLY A 234
LEU A 245
LEU A 238
TYR A 223
 None
 1.32A 5hwkB-2x8pA:
undetectable		 5hwkB-2x8pA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 2x8p CHOLINE-BINDING
PROTEIN F
(Streptococcus
pneumoniae) 		5 / 6 GLY A 213
THR A 212
TYR A 223
GLY A 229
ASN A 226
 None
 1.27A 5k4pA-2x8pA:
undetectable		 5k4pA-2x8pA:
19.29