SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x8r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2x8r GLYCOSYL HYDROLASE
(Aspergillus
fumigatus) 		4 / 6 VAL A 124
ILE A 127
TRP A 184
LEU A 169
 None
 1.11A 1j96A-2x8rA:
4.0		 1j96A-2x8rA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2x8r GLYCOSYL HYDROLASE
(Aspergillus
fumigatus) 		4 / 8 TYR A  56
GLY A  63
THR A  60
ALA A  59
 None
 0.85A 2a1hA-2x8rA:
undetectable
2a1hB-2x8rA:
undetectable		 2a1hA-2x8rA:
19.17
2a1hB-2x8rA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 2x8r GLYCOSYL HYDROLASE
(Aspergillus
fumigatus) 		5 / 11 GLY A 182
ASP A 183
ILE A 144
THR A 155
THR A 146
 None
 1.47A 2f9wA-2x8rA:
undetectable
2f9wB-2x8rA:
undetectable		 2f9wA-2x8rA:
21.25
2f9wB-2x8rA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 2x8r GLYCOSYL HYDROLASE
(Aspergillus
fumigatus) 		3 / 3 LEU A  65
ASN A  97
ARG A 213
 None
 0.72A 2qhfA-2x8rA:
undetectable		 2qhfA-2x8rA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2x8r GLYCOSYL HYDROLASE
(Aspergillus
fumigatus) 		3 / 3 LEU A  64
MET A  38
ASP A 201
 None
 0.79A 3v5wA-2x8rA:
undetectable		 3v5wA-2x8rA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 2x8r GLYCOSYL HYDROLASE
(Aspergillus
fumigatus) 		3 / 3 TRP A 151
TRP A 150
THR A 147
 None
CL  A1219 (-4.6A)
None
 1.48A 4bboB-2x8rA:
undetectable		 4bboB-2x8rA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_B_3QBB203_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 2x8r GLYCOSYL HYDROLASE
(Aspergillus
fumigatus) 		5 / 11 ASP A  16
ASP A 201
ASP A 203
ASP A 194
PHE A  36
 None
 1.32A 4wh5A-2x8rA:
0.0
4wh5B-2x8rA:
0.0		 4wh5A-2x8rA:
18.94
4wh5B-2x8rA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 2x8r GLYCOSYL HYDROLASE
(Aspergillus
fumigatus) 		3 / 3 ASP A  75
ARG A  73
TYR A 116
 None
 0.90A 5a7mA-2x8rA:
3.9		 5a7mA-2x8rA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 2x8r GLYCOSYL HYDROLASE
(Aspergillus
fumigatus) 		3 / 3 ASP A  75
ARG A  73
TYR A 116
 None
 0.90A 5a7mB-2x8rA:
4.8		 5a7mB-2x8rA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 2x8r GLYCOSYL HYDROLASE
(Aspergillus
fumigatus) 		3 / 3 TRP A 126
ILE A 106
GLU A  43
 None
 0.85A 6hcxA-2x8rA:
undetectable		 6hcxA-2x8rA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2x8r GLYCOSYL HYDROLASE
(Aspergillus
fumigatus) 		4 / 7 GLY A  79
THR A  81
HIS A  70
ARG A  73
 None
 0.96A 6jnhA-2x8rA:
undetectable		 6jnhA-2x8rA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2x8r GLYCOSYL HYDROLASE
(Aspergillus
fumigatus) 		4 / 6 GLY A  79
THR A  81
HIS A  70
ARG A  73
 None
 0.92A 6jogA-2x8rA:
undetectable		 6jogA-2x8rA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 2x8r GLYCOSYL HYDROLASE
(Aspergillus
fumigatus) 		5 / 11 GLY A  33
LEU A  64
ALA A  62
ALA A  28
HIS A 198
 None
 1.38A 6qgbA-2x8rA:
undetectable		 6qgbA-2x8rA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 2x8r GLYCOSYL HYDROLASE
(Aspergillus
fumigatus) 		5 / 11 GLY A  33
LEU A  64
ALA A  62
ALA A  28
HIS A 198
 None
 1.39A 6qgbE-2x8rA:
undetectable		 6qgbE-2x8rA:
17.35