SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		5 / 8 GLU A 162
ILE A 208
LEU A 181
MET A 197
GLU A 196
 None
 1.31A 1a29A-2x8uA:
undetectable		 1a29A-2x8uA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		5 / 8 GLU A 162
ILE A 208
MET A 197
GLU A 196
ALA A 199
 None
 1.47A 1a29A-2x8uA:
undetectable		 1a29A-2x8uA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		5 / 9 GLU A 162
ILE A 208
LEU A 181
GLU A 196
ALA A 199
 None
 1.21A 1ctrA-2x8uA:
undetectable		 1ctrA-2x8uA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		4 / 6 ARG A 394
ILE A 399
GLY A 393
ALA A 392
 None
 0.93A 1wrqA-2x8uA:
undetectable		 1wrqA-2x8uA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		4 / 8 GLY A  91
THR A 284
ALA A 285
ALA A 286
 None
 0.47A 2ej3A-2x8uA:
undetectable		 2ej3A-2x8uA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		4 / 8 GLY A  91
THR A 284
ALA A 285
ALA A 286
 None
 0.47A 2ej3C-2x8uA:
undetectable		 2ej3C-2x8uA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		5 / 9 ALA A 325
ALA A 331
GLY A 321
GLY A 189
ILE A 329
 None
 1.26A 2v7bA-2x8uA:
4.6		 2v7bA-2x8uA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		5 / 9 ALA A 325
ALA A 331
GLY A 321
GLY A 189
ILE A 329
 None
 1.25A 2v7bB-2x8uA:
4.3		 2v7bB-2x8uA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		4 / 8 ILE A 132
VAL A 154
TYR A 143
CYH A 146
 None
 1.15A 2xz5A-2x8uA:
undetectable
2xz5C-2x8uA:
undetectable		 2xz5A-2x8uA:
18.14
2xz5C-2x8uA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		4 / 8 ILE A 132
VAL A 154
TYR A 143
CYH A 146
 None
 1.18A 2xz5C-2x8uA:
undetectable
2xz5D-2x8uA:
undetectable		 2xz5C-2x8uA:
18.14
2xz5D-2x8uA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		3 / 3 GLU A 380
HIS A 377
HIS A 301
 None
 0.94A 3co4A-2x8uA:
undetectable		 3co4A-2x8uA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		6 / 10 LEU A 369
GLY A 393
ALA A 392
GLY A 387
LEU A 386
VAL A 354
 None
 1.19A 3em3A-2x8uA:
undetectable		 3em3A-2x8uA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		5 / 12 ASN A 305
LEU A 373
ILE A 385
LEU A 352
PHE A 389
 None
 1.04A 3fl9B-2x8uA:
2.4		 3fl9B-2x8uA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		5 / 10 ASN A 305
LEU A 373
ILE A 385
LEU A 352
PHE A 389
 None
 1.11A 3fl9F-2x8uA:
2.3		 3fl9F-2x8uA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		5 / 12 ASN A 305
LEU A 373
ILE A 385
LEU A 352
PHE A 389
 None
 1.07A 3fl9G-2x8uA:
undetectable		 3fl9G-2x8uA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HP1_A_LLTA401_1
(DEOXYCYTIDINE KINASE)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		5 / 12 PHE A 102
MET A  56
ARG A 299
ALA A 295
GLU A 228
 None
 1.24A 3hp1A-2x8uA:
0.0		 3hp1A-2x8uA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		3 / 3 ARG A 167
ASP A 135
ASP A 163
 None
 0.90A 3jb2A-2x8uA:
undetectable		 3jb2A-2x8uA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		3 / 3 ARG A 167
ASP A 135
ASP A 163
 None
 0.85A 3jb3A-2x8uA:
undetectable		 3jb3A-2x8uA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		3 / 4 SER A 306
GLY A 215
GLU A 182
 None
None
PLP  A1245 (-4.0A)
 0.66A 3raeA-2x8uA:
undetectable
3raeC-2x8uA:
undetectable		 3raeA-2x8uA:
23.30
3raeC-2x8uA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		5 / 12 GLY A 225
GLY A 217
TYR A  55
GLN A 326
VAL A 184
 None
 1.21A 3t7vA-2x8uA:
2.1		 3t7vA-2x8uA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		3 / 3 LEU A 164
MET A 197
ASP A 130
 None
 0.81A 4j7xB-2x8uA:
undetectable		 4j7xB-2x8uA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		5 / 11 LEU A 373
HIS A 310
LEU A 309
VAL A 332
LEU A 320
 None
 1.05A 4p65C-2x8uA:
undetectable
4p65D-2x8uA:
undetectable
4p65J-2x8uA:
undetectable
4p65L-2x8uA:
undetectable		 4p65C-2x8uA:
12.04
4p65D-2x8uA:
6.76
4p65J-2x8uA:
6.76
4p65L-2x8uA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		5 / 11 VAL A 332
LEU A 320
LEU A 373
HIS A 310
LEU A 309
 None
 1.01A 4p65B-2x8uA:
undetectable
4p65D-2x8uA:
undetectable
4p65G-2x8uA:
undetectable
4p65H-2x8uA:
undetectable		 4p65B-2x8uA:
6.76
4p65D-2x8uA:
6.76
4p65G-2x8uA:
12.04
4p65H-2x8uA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		3 / 5 GLY A 217
GLY A 225
GLU A 228
 None
 0.48A 4z2eA-2x8uA:
undetectable
4z2eD-2x8uA:
undetectable		 4z2eA-2x8uA:
23.83
4z2eD-2x8uA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		4 / 7 SER A 276
ALA A 275
HIS A  92
PRO A 278
 None
 0.91A 5dzkD-2x8uA:
undetectable
5dzkR-2x8uA:
undetectable		 5dzkD-2x8uA:
19.04
5dzkR-2x8uA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		5 / 12 SER A 378
ILE A  48
LEU A 352
HIS A 377
LEU A 386
 None
 1.41A 5zwrB-2x8uA:
undetectable		 5zwrB-2x8uA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		5 / 12 LEU A 373
LEU A  50
LEU A 309
GLY A 321
LEU A 320
 None
 0.89A 6b0cD-2x8uA:
3.0		 6b0cD-2x8uA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		4 / 8 LEU A 347
LEU A 352
GLY A 312
ARG A 308
 None
 0.94A 6ce2A-2x8uA:
undetectable		 6ce2A-2x8uA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		4 / 7 VAL A 240
LEU A 264
GLY A 120
GLY A 251
 None
 0.67A 6eu9D-2x8uA:
undetectable		 6eu9D-2x8uA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		3 / 3 THR A 287
ALA A  67
LYS A  69
 None
 0.63A 6fgcA-2x8uA:
undetectable		 6fgcA-2x8uA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 2x8u SERINE
PALMITOYLTRANSFERASE
(Sphingomonas
wittichii) 		3 / 3 THR A 287
ALA A  67
LYS A  69
 None
 0.61A 6fgdA-2x8uA:
2.3		 6fgdA-2x8uA:
23.21