SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		5 / 8 ARG X 226
THR X 224
VAL X 223
LEU X 292
ALA X 280
 None
 1.37A 1fiqC-2x8xX:
undetectable		 1fiqC-2x8xX:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		5 / 9 ARG X 226
THR X 224
VAL X 223
LEU X 292
ALA X 280
 None
 1.39A 1fo4A-2x8xX:
undetectable		 1fo4A-2x8xX:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		4 / 6 PHE X 119
PHE X 114
ASN X 111
ASN X 174
 None
 1.42A 1t9uA-2x8xX:
undetectable		 1t9uA-2x8xX:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		5 / 6 ARG X 226
THR X 224
VAL X 223
LEU X 292
ALA X 280
 None
 1.40A 2e1qA-2x8xX:
undetectable		 2e1qA-2x8xX:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		4 / 7 LEU X 268
LEU X 271
PHE X 274
LEU X 294
 None
 0.58A 2vq5B-2x8xX:
undetectable		 2vq5B-2x8xX:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		5 / 12 PRO X 143
LEU X 173
VAL X 199
PRO X 203
LEU X 213
 None
 1.39A 3a51B-2x8xX:
undetectable		 3a51B-2x8xX:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		5 / 9 ARG X 226
THR X 224
VAL X 223
LEU X 292
ALA X 280
 None
 1.37A 3ax7B-2x8xX:
undetectable		 3ax7B-2x8xX:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		5 / 9 VAL X 199
ILE X 185
GLY X 181
PRO X 203
THR X 202
 None
 1.20A 3el4B-2x8xX:
undetectable		 3el4B-2x8xX:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		4 / 7 TYR X 189
VAL X 215
VAL X 219
GLY X 152
 None
 0.88A 3kmoB-2x8xX:
undetectable		 3kmoB-2x8xX:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		5 / 9 ARG X 226
THR X 224
VAL X 223
LEU X 292
ALA X 280
 None
 1.37A 3unaA-2x8xX:
undetectable		 3unaA-2x8xX:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		5 / 9 ARG X 226
THR X 224
VAL X 223
LEU X 292
ALA X 280
 None
 1.38A 3unaB-2x8xX:
undetectable		 3unaB-2x8xX:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		5 / 9 ARG X 226
THR X 224
VAL X 223
LEU X 292
ALA X 280
 None
 1.37A 3uncA-2x8xX:
undetectable		 3uncA-2x8xX:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		5 / 9 ARG X 226
THR X 224
VAL X 223
LEU X 292
ALA X 280
 None
 1.36A 3uncB-2x8xX:
undetectable		 3uncB-2x8xX:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		5 / 7 ARG X 226
THR X 224
VAL X 223
LEU X 292
ALA X 280
 None
 1.34A 3uniA-2x8xX:
undetectable		 3uniA-2x8xX:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		4 / 6 ILE X 296
VAL X 279
LEU X 281
ILE X 293
 None
 0.85A 4asdA-2x8xX:
undetectable		 4asdA-2x8xX:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		5 / 9 ILE X 164
PHE X 188
VAL X 199
VAL X 155
LEU X 156
 None
 1.23A 4g1bC-2x8xX:
undetectable		 4g1bC-2x8xX:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 2x8x TLR1789 PROTEIN
(Thermosynechococ
cus
elongatus) 		3 / 3 ARG X 299
PHE X 274
GLY X 272
 None
 0.79A 6fgdA-2x8xX:
undetectable		 6fgdA-2x8xX:
21.70