SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 5 ASP A 304
HIS A 308
HIS A 347
HIS A 435
 ZN  A1475 ( 2.0A)
ZN  A1475 ( 3.2A)
ZN  A1476 ( 3.1A)
ZN  A1475 ( 3.2A)
 0.38A 1ei6A-2x98A:
15.9		 1ei6A-2x98A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 8 ASP A  56
ASP A 304
HIS A 308
HIS A 347
HIS A 435
 ZN  A1476 (-2.2A)
ZN  A1475 ( 2.0A)
ZN  A1475 ( 3.2A)
ZN  A1476 ( 3.1A)
ZN  A1475 ( 3.2A)
 0.46A 1ei6C-2x98A:
15.8		 1ei6C-2x98A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 8 PHE A 122
SER A 343
ALA A  52
PHE A 295
 None
 1.05A 1gm7A-2x98A:
undetectable
1gm7B-2x98A:
0.2		 1gm7A-2x98A:
19.05
1gm7B-2x98A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		3 / 3 GLU A 167
HIS A 170
HIS A 255
 None
PO4  A1474 (-4.5A)
None
 0.66A 1oe2A-2x98A:
undetectable		 1oe2A-2x98A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 12 GLY A 307
ASP A 346
ILE A  54
LEU A 297
VAL A 298
 None
ZN  A1476 (-2.3A)
None
None
None
 1.17A 1r30A-2x98A:
undetectable		 1r30A-2x98A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 8 LEU A 367
THR A  61
ALA A  65
LEU A  69
 None
 0.99A 1sn5C-2x98A:
undetectable		 1sn5C-2x98A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 12 LEU A 473
VAL A 136
ALA A 119
PHE A 122
VAL A 126
 None
 1.36A 2g72A-2x98A:
undetectable		 2g72A-2x98A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		3 / 3 SER A 100
THR A 344
PHE A 340
 None
 0.62A 2x91A-2x98A:
undetectable		 2x91A-2x98A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		3 / 3 ASP A 304
THR A 187
GLU A 167
 ZN  A1475 ( 2.0A)
None
None
 0.74A 2zifB-2x98A:
undetectable		 2zifB-2x98A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 12 VAL A 440
PHE A 340
LEU A 465
ALA A 460
PHE A 452
 None
None
None
CL  A1486 ( 4.0A)
None
 1.41A 3apxA-2x98A:
undetectable		 3apxA-2x98A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 8 LEU A 297
PHE A 295
VAL A 461
ALA A  50
 None
 0.98A 3ax9A-2x98A:
undetectable		 3ax9A-2x98A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 8 HIS A 435
HIS A 308
ASP A  56
GLY A  57
 ZN  A1475 ( 3.2A)
ZN  A1475 ( 3.2A)
ZN  A1476 (-2.2A)
None
 0.87A 3c0zB-2x98A:
undetectable		 3c0zB-2x98A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 7 GLY A 345
HIS A 347
ASP A  56
GLN A  62
 None
ZN  A1476 ( 3.1A)
ZN  A1476 (-2.2A)
None
 0.93A 3fi0P-2x98A:
undetectable		 3fi0P-2x98A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 7 VAL A 277
VAL A 281
LEU A 284
SER A 285
 None
 0.92A 3hs6B-2x98A:
undetectable		 3hs6B-2x98A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		3 / 3 SER A 375
ASP A 261
ASN A 268
 None
 0.79A 3lsfB-2x98A:
undetectable
3lsfE-2x98A:
undetectable		 3lsfB-2x98A:
19.03
3lsfE-2x98A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		3 / 3 ASP A 261
ASN A 268
SER A 375
 None
 0.84A 3lsfB-2x98A:
undetectable
3lsfE-2x98A:
undetectable		 3lsfB-2x98A:
19.03
3lsfE-2x98A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 12 VAL A 277
VAL A 281
LEU A 284
SER A 285
LEU A 328
 None
 0.83A 3n8yB-2x98A:
undetectable		 3n8yB-2x98A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		3 / 3 HIS A 305
ARG A 302
GLU A 299
 None
None
MG  A1477 (-2.6A)
 0.91A 3qf1A-2x98A:
undetectable		 3qf1A-2x98A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 9 ALA A  52
GLY A 161
ILE A 163
PRO A 173
THR A 172
 None
None
None
None
MG  A1477 (-3.1A)
 1.21A 3spkA-2x98A:
undetectable		 3spkA-2x98A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 12 HIS A 435
GLY A 434
VAL A 303
ASP A 304
ALA A 117
 ZN  A1475 ( 3.2A)
None
None
ZN  A1475 ( 2.0A)
None
 1.07A 3sueC-2x98A:
undetectable		 3sueC-2x98A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		3 / 3 GLN A 370
THR A 373
THR A 374
 CL  A1483 (-3.7A)
None
CL  A1483 (-4.1A)
 0.57A 4fu9A-2x98A:
undetectable		 4fu9A-2x98A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		3 / 3 GLN A 370
THR A 373
THR A 374
 CL  A1483 (-3.7A)
None
CL  A1483 (-4.1A)
 0.57A 4fufA-2x98A:
undetectable		 4fufA-2x98A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 9 VAL A 136
GLU A 181
ILE A 133
SER A 124
ALA A 123
 None
 1.09A 4fwdA-2x98A:
undetectable		 4fwdA-2x98A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 8 SER A 154
LEU A 297
ALA A 123
THR A 148
 None
 0.90A 4ikjA-2x98A:
undetectable
4ikjB-2x98A:
undetectable		 4ikjA-2x98A:
13.71
4ikjB-2x98A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 8 LEU A 297
ALA A 123
THR A 148
SER A 154
 None
 0.91A 4ikkA-2x98A:
undetectable
4ikkB-2x98A:
undetectable		 4ikkA-2x98A:
13.71
4ikkB-2x98A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 11 GLN A 186
ALA A 171
ALA A 174
ALA A 175
VAL A 146
 None
PO4  A1474 ( 4.9A)
None
None
None
 1.14A 4j6cA-2x98A:
undetectable		 4j6cA-2x98A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 10 GLN A 186
ALA A 171
ALA A 174
ALA A 175
VAL A 146
 None
PO4  A1474 ( 4.9A)
None
None
None
 1.15A 4j6cB-2x98A:
undetectable		 4j6cB-2x98A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 12 ASP A 433
HIS A 347
HIS A 435
GLY A 434
ASP A  56
 MG  A1480 (-2.4A)
ZN  A1476 ( 3.1A)
ZN  A1475 ( 3.2A)
None
ZN  A1476 (-2.2A)
 1.01A 4lxzA-2x98A:
3.0		 4lxzA-2x98A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 12 ASP A 433
HIS A 347
HIS A 435
GLY A 434
ASP A  56
 MG  A1480 (-2.4A)
ZN  A1476 ( 3.1A)
ZN  A1475 ( 3.2A)
None
ZN  A1476 (-2.2A)
 1.03A 4lxzC-2x98A:
3.2		 4lxzC-2x98A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 12 HIS A 435
HIS A 308
GLY A 307
ASP A  56
GLY A  57
 ZN  A1475 ( 3.2A)
ZN  A1475 ( 3.2A)
None
ZN  A1476 (-2.2A)
None
 1.21A 4lxzC-2x98A:
3.2		 4lxzC-2x98A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 5 THR A 164
PRO A 173
PHE A 210
TYR A 193
 None
 1.40A 4mf6A-2x98A:
0.0		 4mf6A-2x98A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 6 PHE A 122
ASP A  56
HIS A 347
THR A 113
 None
ZN  A1476 (-2.2A)
ZN  A1476 ( 3.1A)
None
 1.28A 4paeA-2x98A:
undetectable		 4paeA-2x98A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 5 SER A 375
GLU A 317
ASP A 257
ASN A 272
 None
 1.40A 4pclA-2x98A:
3.4		 4pclA-2x98A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 6 LEU A 367
THR A  61
ALA A  65
LEU A  69
 None
 1.03A 4pwjA-2x98A:
undetectable		 4pwjA-2x98A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 9 THR A 128
ALA A 118
ILE A 133
GLY A 131
ASP A  56
 None
None
None
None
ZN  A1476 (-2.2A)
 1.12A 4qvqK-2x98A:
undetectable
4qvqL-2x98A:
undetectable		 4qvqK-2x98A:
23.35
4qvqL-2x98A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 9 THR A 128
ALA A 118
ILE A 133
GLY A 131
ASP A  56
 None
None
None
None
ZN  A1476 (-2.2A)
 1.12A 4qvqY-2x98A:
undetectable
4qvqZ-2x98A:
undetectable		 4qvqY-2x98A:
23.35
4qvqZ-2x98A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 7 GLY A 131
ALA A 132
THR A 128
SER A 124
 None
 0.87A 4r1zB-2x98A:
undetectable		 4r1zB-2x98A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 9 ALA A 119
ALA A 174
ALA A 177
ALA A 123
SER A 124
 None
 1.33A 4twdA-2x98A:
undetectable
4twdB-2x98A:
undetectable
4twdC-2x98A:
undetectable
4twdD-2x98A:
undetectable
4twdE-2x98A:
undetectable		 4twdA-2x98A:
21.16
4twdB-2x98A:
21.16
4twdC-2x98A:
21.16
4twdD-2x98A:
21.16
4twdE-2x98A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 12 SER A  45
LEU A 150
LEU A 469
ALA A 153
ALA A  50
 MG  A1481 ( 2.3A)
None
None
None
None
 1.25A 4x1kA-2x98A:
2.5
4x1kB-2x98A:
undetectable		 4x1kA-2x98A:
24.05
4x1kB-2x98A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 12 ALA A 309
GLY A 307
GLY A 350
LEU A 352
GLU A 320
 None
 0.79A 5c0oH-2x98A:
undetectable		 5c0oH-2x98A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 12 ILE A 202
VAL A 201
GLY A 248
HIS A 255
LEU A 273
 None
 1.15A 5ergB-2x98A:
undetectable		 5ergB-2x98A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		6 / 12 VAL A 461
GLU A 151
ALA A  52
VAL A 342
THR A 160
TYR A 158
 None
None
None
None
None
MG  A1481 (-4.7A)
 1.37A 5igtA-2x98A:
undetectable		 5igtA-2x98A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		3 / 3 GLN A 186
THR A 169
ASP A 209
 None
 0.92A 5k9dA-2x98A:
undetectable		 5k9dA-2x98A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 10 THR A 128
ALA A 118
ALA A 132
GLY A 131
ASP A  56
 None
None
None
None
ZN  A1476 (-2.2A)
 1.14A 5lf3H-2x98A:
undetectable
5lf3I-2x98A:
undetectable		 5lf3H-2x98A:
19.03
5lf3I-2x98A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 4 GLN A 323
THR A 322
LEU A 367
LEU A  69
 None
 1.23A 5m5kB-2x98A:
undetectable		 5m5kB-2x98A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 12 GLY A 345
HIS A 347
VAL A 303
ILE A  51
ALA A  52
 None
ZN  A1476 ( 3.1A)
None
None
None
 1.09A 5n0sA-2x98A:
2.4		 5n0sA-2x98A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 12 GLY A 345
HIS A 347
VAL A 303
ILE A  51
ALA A  52
 None
ZN  A1476 ( 3.1A)
None
None
None
 1.09A 5n0wB-2x98A:
3.2		 5n0wB-2x98A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 12 GLY A 345
HIS A 347
VAL A 303
ILE A  51
ALA A  52
 None
ZN  A1476 ( 3.1A)
None
None
None
 1.09A 5n0xA-2x98A:
3.1		 5n0xA-2x98A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 7 ASP A  56
GLY A 301
ASP A 346
HIS A 308
ASP A 304
 ZN  A1476 (-2.2A)
MG  A1477 ( 4.5A)
ZN  A1476 (-2.3A)
ZN  A1475 ( 3.2A)
ZN  A1475 ( 2.0A)
 1.45A 5nnwD-2x98A:
undetectable		 5nnwD-2x98A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		5 / 7 ASP A  56
GLY A 301
ASP A 346
HIS A 308
ASP A 304
 ZN  A1476 (-2.2A)
MG  A1477 ( 4.5A)
ZN  A1476 (-2.3A)
ZN  A1475 ( 3.2A)
ZN  A1475 ( 2.0A)
 1.49A 5no9D-2x98A:
undetectable		 5no9D-2x98A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 4 GLU A 424
THR A 420
THR A 398
LEU A 403
 None
 1.42A 5v96A-2x98A:
undetectable		 5v96A-2x98A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 4 GLU A 424
THR A 420
THR A 398
LEU A 403
 None
 1.43A 5v96B-2x98A:
undetectable		 5v96B-2x98A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 4 GLU A 424
THR A 420
THR A 398
LEU A 403
 None
 1.44A 5v96C-2x98A:
undetectable		 5v96C-2x98A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 4 GLU A 424
THR A 420
THR A 398
LEU A 403
 None
 1.43A 5v96D-2x98A:
undetectable		 5v96D-2x98A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		3 / 3 THR A 172
GLU A 299
HIS A 305
 MG  A1477 (-3.1A)
MG  A1477 (-2.6A)
None
 0.91A 5xiqB-2x98A:
undetectable		 5xiqB-2x98A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 5 ALA A  47
SER A  45
GLY A 470
TYR A 158
 None
MG  A1481 ( 2.3A)
None
MG  A1481 (-4.7A)
 1.19A 5yodD-2x98A:
undetectable		 5yodD-2x98A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 4 MET A  58
GLY A  57
HIS A 347
GLY A  59
 None
None
ZN  A1476 ( 3.1A)
None
 1.36A 6fgdA-2x98A:
undetectable		 6fgdA-2x98A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 4 MET A  58
GLY A  57
HIS A 347
GLY A 345
 None
None
ZN  A1476 ( 3.1A)
None
 0.99A 6fgdA-2x98A:
undetectable		 6fgdA-2x98A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		4 / 5 GLN A  62
THR A 166
HIS A 170
GLY A 307
 None
MG  A1477 ( 4.5A)
PO4  A1474 (-4.5A)
None
 1.17A 6gbnC-2x98A:
undetectable		 6gbnC-2x98A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2x98 ALKALINE PHOSPHATASE
(Halobacterium
salinarum) 		3 / 3 HIS A 170
HIS A 305
HIS A 255
 PO4  A1474 (-4.5A)
None
None
 0.68A 6giqa-2x98A:
undetectable		 6giqa-2x98A:
20.33